Effects of a Standardized Panax ginseng Extract on the Skeletal Muscle of the Rat: A Comparative Study in Animals at Rest and Under Exercise

Ferrando, Ana; Vila, L.; Voces, J.; Cabral, Alícia; Alvarez, Ana I.; Prieto, J. E.

doi:10.1055/s-1999-14081

Cited by 21 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…P. ginseng extract is known to increase capillary density and the oxidative capacity of muscles with greater aerobic potential (30). Acute pre-treatment of mice with crude extract increased their endurance in the swimming and running tests, but the reason for this increase was linked to the availability of muscle substrates and their utilization (31).…”

Section: Soleusmentioning

confidence: 99%

“…These activities are focused on mitochondria as the major site of free radical generation. Ferrando et al (30) showed that ginseng extract increased mitochondrial density in rat oxidative muscles after a 50-mg/kg dose for three months. On the other hand, down-regulation in CS activity has been reported in muscle and liver measured by GSH depletion and mitochondrial oxidative damage (33).…”

Section: Soleusmentioning

confidence: 99%

See 1 more Smart Citation

Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats

Voces

Oliveira

Prieto

et al. 2004

Braz J Med Biol Res

Self Cite

View full text Add to dashboard Cite

Enzymatic activity was analyzed in the soleus, gastrocnemius (red and white) and plantaris muscles of acutely exercised rats after long-term administration of Panax ginseng extract in order to evaluate the protective role of ginseng against skeletal muscle oxidation. Ginseng extract (3, 10, 100, or 500 mg/kg) was administered orally for three months to male Wistar rats weighing 200 ± 50 g before exercise and to non-exercised rats (N = 8/group). The results showed a membrane stabilizing capacity of the extract since mitochondrial function measured on the basis of citrate synthase and 3-hydroxyacyl-CoA dehydrogenase activities was reduced, on average, by 20% (P < 0.05) after exercise but the activities remained unchanged in animals treated with a ginseng dose of 100 mg/kg. Glutathione status did not show significant changes after exercise or treatment. Lipid peroxidation, measured on the basis of malondialdehyde levels, was significantly higher in all muscles after exercise, and again was reduced by about 74% (P < 0.05) by the use of ginseng extract. The administration of ginseng extract was able to protect muscle from exercise-induced oxidative stress irrespective of fiber type. Correspondence

show abstract

Section: Soleusmentioning

confidence: 99%

Section: Soleusmentioning

confidence: 99%

Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats

Voces

Oliveira

Prieto

et al. 2004

Braz J Med Biol Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Many studies have been made with this extract from PG, but the effectiveness of this plant still needs to be proven, due to the large number of investigations have not shown any effect in increasing physical performance with humans (Scaglione et al, 2005). Fernando et al (1999) showed in their research a raise in capillary density and muscle mitochondrial content of mice, suggesting that prolonged treatment with G115 (50mg/kg for 12 weeks) improve the aerobic output and therefore the physical performance (Ferrando et al, 1999). Research such as Engels et al (2001), executed with double-blind trials (placebo group and G115 group) with active women, showed no significant changes in peak anaerobic power, anaerobic power average, fatigue and post-exercise recovery after supplementation (Engels et al, 2001).…”

Section: Volume 8 | Issue 4 | 2013 | 1058mentioning

confidence: 97%

Effects of adaptogen supplementation on sport performance. A recent review of published studies

Domene¹

2013

JHSE

View full text Add to dashboard Cite

Molinos, A. (2013). Effects of adaptogen supplementation on sport performance. A recent review of published studies. J. Hum. Sport Exerc., 8(4), pp.1054-1066. Objective: Adaptogens are a new class of metabolic regulators (plants from natural origin) which have been shown to increase the ability of organism to adapt environmental factors and to avoid body damage. These properties offer the possibility to utilize them to increase the performance in situations of mental and physical stress, and thus used it to improve sport performance. Methods: A literature search was conducted for articles published until December 2012 in major databases. Publications were searched without language restrictions, using combination of Keywords. Results: Latest research show that Rhodiola rosea, Eleutherococcus senticosus, Schisandra chinensis, Panax ginseng and Erkang offer some physical and mental benefits to use in sport nutrition.Conclusion: This review demonstrate Adaptogen supplementation can improve the sport performance, however there are not enough reliable studies to conclude this assertion as absolute in all sports, therefore we suggest further researches with any of these Adaptogens in order to ascertain this results.

show abstract

“…RG contains various ginsenosides, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol, and has been widely used as an ergogenic aid. Although only one human study has found an association between RG intake and exercise performance (1), several rat studies have demonstrated a positive association between RG intake and exercise performance (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Effects of Red Ginseng Intake on Muscle Injury Due to Eccentric Exercise

Jung

Kim

Lee³

et al. 2010

JFN

View full text Add to dashboard Cite

This study examined the effects of Korean red ginseng (RG) on muscle injury induced by eccentric exercise. Eighteen college male students were randomly assigned to either the RG group or the placebo group (P). The RG group ingested RG extract at 20 g/day (mixed with 200 mL of water) for 7 days prior to performing a downhill treadmill exercise and for 3 days after performing the downhill treadmill exercise, while the P group ingested 200 mL of water containing Agastachis Herba for 7 days prior to and 3 days following a downhill treadmill exercise. All subjects performed 2 bouts of a downhill treadmill exercise (6 km, -14 degree slope, 12 km/hr speed) with a 5 minute resting interval between bouts. Blood samples were drawn immediately before and after exercise, and at 1 hr, 24 hr, 48 hr, and 72 hr. Two-way repeated ANOVA documented that creatine kinase (CK) levels in the RG group were significantly reduced at 48 hr after exercise, as compared with P group, and remained constant until 72 hr after exercise. Lactate levels in the RG group were also significantly lower at 24 hr and 72 hr after exercise as compared to the P group. We conclude that supplementation of RGreduces CK levels and may prevent muscle injury induced by eccentric exercise.

show abstract

Effects of a Standardized Panax ginseng Extract on the Skeletal Muscle of the Rat: A Comparative Study in Animals at Rest and Under Exercise

Cited by 21 publications

References 19 publications

Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats

Ginseng administration protects skeletal muscle from oxidative stress induced by acute exercise in rats

Effects of adaptogen supplementation on sport performance. A recent review of published studies

Effects of Red Ginseng Intake on Muscle Injury Due to Eccentric Exercise

Contact Info

Product

Resources

About