Effects of a vitamin E-modified dialysis membrane on neutrophil superoxide anion radical production

Shimazu, Takekazu; Ominato, Masayuki; Toyama, Katsuhide; Yasuda, Takashi; Sato, Takeo; Maeba, Teruhiko; Owada, Shigeki; Ishida, Masaharu

doi:10.1046/j.1523-1755.2001.07827.x

Cited by 14 publications

(11 citation statements)

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“…During HD, ROS are produced by radical chain reactions and these are caused by superoxide released from neutrophils in bioincompatible dialyzers or blood circuits, activation of nicotinamide adenine dinucleotide phosphatem and decreased antioxidants and antioxidative levels [3,4,5, 27, 28]. Certain ROS attack unsaturated fatty acid and initiate radical chain reactions.…”

Section: Discussionmentioning

confidence: 99%

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Elimination of Lipid Peroxide during Hemodialysis

Obara

Hirayama²,

Gotoh³

et al. 2007

Nephron Clin Pract

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Background/Aims: This study is aimed to show the antioxidative effect of hemodialysis (HD) by demonstrating the elimination of toxic lipid peroxides. Methods: Blood samples were obtained from patients on regular maintenance HD before and 15, 30, 60, 120 and 240 min after the start of each HD session. Plasma cholesteryl ester hydroperoxide (CE-OOH), phosphatidylcholine hydroperoxide (PC-OOH), and eliminators of lipid peroxides (LOOH) such as apolipoprotein A-I (apoA-I) and lecithin:cholesterol acyltransferase (LCAT) were investigated. The hydroxyl radical scavenging activity was measured for the evaluation of the pro-oxidative side. Results: CE-OOH and PC-OOH were elevated in patients with chronic kidney disease both on and not on HD, while these values were much higher in HD patients. CE-OOH quickly dropped during the first 30 min of HD, then gradually decreased until 240 min. CE-OOH concentrations were related to those of apoA-I. In contrast, PC-OOH showed an increase 30 min after the start of HD, a change which resembled that of LCAT and was the reverse of the hydroxyl radical scavenging activity. Conclusion: These results demonstrate the antioxidative action through CE-OOH elimination involving apoA-I. The pro- and antioxidative effects of HD on LOOH are not uniform but PC-OOH is mainly influenced prooxidatively.

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Section: Discussionmentioning

confidence: 99%

“…However, it is still controversial whether the hemodialysis procedure itself increases oxidative stress [1,2,3,4,5]. Theoretically, multiple changes in redox status occur in both the pro-oxidative or anti-oxidative directions during hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

Elimination of Lipid Peroxide during Hemodialysis

Obara

Hirayama²,

Gotoh³

et al. 2007

Nephron Clin Pract

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“…The analysis of our results is difficult because this is the first study on soluble adhesion molecules in patients on VE-modified membranes. Firstly, VE-coated dialyzers reduce neutrophil activation during HD and weaken the effects of the oxidative burst [18,19]. Secondly, Nagata et al [20] showed that sP-selectin can bind to P-selectin counter-receptors on platelets, thus inhibiting formation of platelet-leukocyte aggregates and leukocyte superoxide production.…”

Section: Discussionmentioning

confidence: 99%

Soluble adhesion molecules in children and young adults on chronic hemodialysis

Musiał

Zwołińska²,

Polak−Jonkisz³

et al. 2004

Pediatric Nephrology

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Children on chronic hemodialysis (HD) present with impaired immunity that may result from disturbances in leukocyte migration, caused by changes in expression of adhesion molecules on endothelium and immunocompetent cells. However, it is still not clear whether the type of dialyzer or a single dialysis session influences the concentrations of soluble adhesion molecules in these patients. We evaluated by ELISA serum levels of soluble (s) VCAM-1, ICAM-1, L-selectin, and P-selectin in 22 patients on cuprophane HD (CU), 8 on polysulfone HD (PS), 10 on vitamin E-modified cellulose HD (VE), and 15 controls. In all HD patients, sVCAM-1 levels were elevated compared with controls and were higher in CU than in VE. The sICAM-1 concentrations were increased in VE compared with controls, but remained unchanged in CU and PS. The sL-selectin levels were reduced in all HD patients. The mean values of sP-selectin were comparable in CU, PS, and controls. The lowest levels were observed in VE. In CU patients, sVCAM-1, sICAM-1, and sP-selectin concentrations rose after HD. A single PS session had no impact on adhesion molecules, whereas a VE session increased the level of sVCAM-1. The type of dialysis membrane may change the profile of adhesion molecule concentrations, thus influencing the immune system of a child on HD. The increase in levels of adhesion molecules in the course of a single HD session, which was pronounced in CU and VE patients, suggests poor biocompatibility of these dialyzers.

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“…Oxidative stress causes an imbalance between the production and elimination of ROSs, which may play a crucial role in the pathogenesis and progression of complications in ESRD. 1 Among ROSs, hydroxyl radicals (·OH) are regarded to have the most potent activity in various kinds of tissue injuries; for example, arterial sclerosis, peripheral nervous system disorder, hemolytic anemia, and renal osteodystrophy. 2 However, inconsistent results are reported concerning the production and elimination of ·OH in patients with ESRD.…”

Section: Introductionmentioning

confidence: 99%