Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs

Monteiro, Eduardo Raposo; Coelho, Karina; Bressan, Thaís Feres; Simoes, C.; Monteiro, Betânia Souza

doi:10.1111/vaa.12265

Cited by 27 publications

(24 citation statements)

References 29 publications

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“…Mean±SD temperature and ETCO 2 for all 18 dogs were 37.1±0. In a previous study, the ISO MAC determined in dogs was 1.20% (MONTEIRO et al, 2016). This previous study was performed in the same laboratory and using the same methodology of the present study.…”

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confidence: 99%

“…Morphine has been used to provide analgesia/antinociception in dogs (MURPHY & HUG, 1992;KO et al, 2009;AGUADO et al, 2011;MONTEIRO et al, 2016). As with other µ-opioid agonists, morphine decreased the minimum alveolar concentration (MAC) of enflurane in a dose-related manner in dogs (MURPHY & HUG, 1992).…”

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confidence: 99%

“…This previous study was performed in the same laboratory and using the same methodology of the present study. Because a control ISO MAC had already been determined in this previous study (MONTEIRO et al, 2016), we decided not to include a control group in the present study. In the study reported here, the estimated ISO MAC in the MOR 0.5 and MOR 1.0 groups is respectively 18% and 33% lower than the 1.20% value reported in the control group by MONTEIRO et al (2016).…”

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confidence: 99%

“…Because a control ISO MAC had already been determined in this previous study (MONTEIRO et al, 2016), we decided not to include a control group in the present study. In the study reported here, the estimated ISO MAC in the MOR 0.5 and MOR 1.0 groups is respectively 18% and 33% lower than the 1.20% value reported in the control group by MONTEIRO et al (2016). The findings of the present study are in agreement with a previous study that demonstrated a dose dependent reduction on enflurane MAC by morphine in dogs (MURPHY & HUG JR, 1982).…”

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confidence: 99%

“…The ISO MAC was determined by the upand-down method as reported in previous studies in dogs (AGUADO et al, 2011;MONTEIRO et al, 2016). The ETiso for the first dog in each group was set at 0.8%.…”

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Minimum alveolar concentration of isoflurane in dogs administered two morphine doses

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This study aimed to evaluate the effects of intramuscular 0.5mg kg-1 (MOR0.5) and 1.0mg kg-1 (MOR1.0) morphine premedication on the minimum alveolar concentration of isoflurane (ISOMAC) in dogs. Eighteen client-owned female dogs were scheduled for elective ovariohysterectomy. Dogs received intramuscular MOR0.5 or MOR1.0 as premedication and propofol IV for induction of anesthesia. Isoflurane was delivered for maintenance of anesthesia and dogs were maintained under normocapnia and normothermia. Determinations of the ISOMAC were conducted by use of the “up-and-down” method. Noxious stimulus (placement of Backhaus towel clamps, a midline skin incision and subcutaneous tissue dissection) was delivered approximately 50 minutes after premedication with MOR0.5 or MOR1.0. The calculated ISOMAC was 0.98±0.15% in MOR0.5 and 0.80±0.08% in MOR1.0. The ISOMAC was significantly lower in MOR1.0 compared with MOR0.5 (P=0.010). Results of this study suggested that intramuscular premedication with morphine 0.5 and 1.0mg kg-1 decreases the ISOMAC in a dose-related manner in dogs.

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Minimum alveolar concentration of isoflurane in dogs administered two morphine doses

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Section II: Drug formulary

Floriano¹,

Shelby²

2022

Small Animal Anesthesia Techniques

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Premedicants in cats and dogs: which one should you choose and when?

Murrell¹

2022

In Practice

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Background: Premedication is an integral part of any anaesthetic protocol and the drugs chosen for premedication will determine the characteristics of the ensuing anaesthetic. Choosing appropriate premedicant drugs for the individual patient is vital to ensure a smooth and stress‐free anaesthetic. Normally, a balanced premedication protocol involving both a sedative and a hypnotic is advocated. This allows the two key aims of premedication – sedation and analgesia – to be met. Synergistic sedation between most sedatives and opioids also means that combining these drugs allows lower doses of each individual agent to be used.Aim of the article: This article discusses how it is important to know the clinical pharmacology of the different drugs used for premedication in order to make a rational decision about premedicant selection. One way to think about premedicant selection is based on the American Society of Anaesthesiologists (ASA) physical status classification system of the cat or dog, whereby the health status of the individual is used to inform about suitable premedication protocols.

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Effects of acepromazine-morphine and acepromazine-methadone premedication on the minimum alveolar concentration of isoflurane in dogs

Cited by 27 publications

References 29 publications

Minimum alveolar concentration of isoflurane in dogs administered two morphine doses

Minimum alveolar concentration of isoflurane in dogs administered two morphine doses

Section II: Drug formulary

Premedicants in cats and dogs: which one should you choose and when?

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