2007
DOI: 10.1164/rccm.200608-1199oc
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Effects of Acetazolamide on Ventilatory, Cerebrovascular, and Pulmonary Vascular Responses to Hypoxia

Abstract: Acetazolamide has complex effects on ventilation, PVR, and CBF that converge to optimize brain oxygenation and may be a valuable means to prevent/treat high-altitude pulmonary edema.

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Cited by 105 publications
(94 citation statements)
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“…In accordance with previous studies (38,41), acetazolamide induced a metabolic acidosis and a significant rise in mean resting ventilation coupled to a rise in end-tidal and arterial PO 2 and a fall in arterial and end-tidal PCO 2 (Table 1).…”
Section: Resultssupporting
confidence: 92%
See 2 more Smart Citations
“…In accordance with previous studies (38,41), acetazolamide induced a metabolic acidosis and a significant rise in mean resting ventilation coupled to a rise in end-tidal and arterial PO 2 and a fall in arterial and end-tidal PCO 2 (Table 1).…”
Section: Resultssupporting
confidence: 92%
“…Thus, acetazolamide's effects at high altitude may at least partly be due to the metabolic acidosis. Further studies are warranted to see if additional effects of acetazolamide, for example on pulmonary vessels (38), may also contribute to its beneficial effects.…”
Section: Expressing Hypoxic Sensitivity Asmentioning
confidence: 99%
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“…Furthermore, it is used to improve blood gases in obstructive lung disease and to restore acid-base values in metabolic alkalosis, reviewed by (30). ACTZ is also widely used against acute mountain sickness (1,18,29), most likely because it is able to reduce hypoxic pulmonary vasoconstriction and to prevent high-altitude pulmonary edema (2,32). However, there is growing evidence from recent studies in different species that ACTZ may prevent hypoxic pulmonary vasoconstriction entirely independent of carbonic anhydrase inhibition (11) and rather may diminish the hypoxia-induced rise in intracellular Ca 2ϩ in pulmonary arterial smooth muscle cells (25).…”
mentioning
confidence: 99%
“…A recent human study using the dynamic end-tidal forcing technique showed that 750 mg/day of acetazolamide (250 mg tid started 1 day before an acute normobaric hypoxic exposure) was effective in inhibiting pulmonary vascular resistance (Teppema et al, 2007) with 12% O 2 , but the result was obtained in a simulated altitude. Basynat et al (2008) found that acetazolamide fails to decrease PASP at high altitude in already partially acclimatized humans.…”
Section: Discussionmentioning
confidence: 99%