Effects of Acoustic Insonation Parameters on Ultrasound Contrast Agent Destruction

Yeh, Chih‐Kuang; Su, Shin-Yuan

doi:10.1016/j.ultrasmedbio.2007.12.020

Cited by 41 publications

(37 citation statements)

References 30 publications

(40 reference statements)

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“…Nucleation of cavitation has been shown to occur via the rupture of the shell of the UCA (Yeh and Su, 2008), thereby liberating the gas. Previous calculations have predicted that resonant-sized UCAs will rupture before the detection of subharmonic emissions .…”

Section: A Comparison Of Uh and Bb Thresholdsmentioning

confidence: 99%

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Gruber

Bader

Holland

2014

The Journal of the Acoustical Society of America

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Ultrasound contrast agents (UCAs) can be employed to nucleate cavitation to achieve desired bioeffects, such as thrombolysis, in therapeutic ultrasound applications. Effective methods of enhancing thrombolysis with ultrasound have been examined at low frequencies (<1 MHz) and low amplitudes (<0.5 MPa). The objective of this study was to determine cavitation thresholds for two UCAs exposed to 120-kHz ultrasound. A commercial ultrasound contrast agent (Definity V R ) and echogenic liposomes were investigated to determine the acoustic pressure threshold for ultraharmonic (UH) and broadband (BB) generation using an in vitro flow model perfused with human plasma. Cavitation emissions were detected using two passive receivers over a narrow frequency bandwidth (540-900 kHz) and a broad frequency bandwidth (0.54-1.74 MHz). UH and BB cavitation thresholds occurred at the same acoustic pressure (0.3 6 0.1 MPa, peak to peak) and were found to depend on the sensitivity of the cavitation detector but not on the nucleating contrast agent or ultrasound duty cycle.

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Section: A Comparison Of Uh and Bb Thresholdsmentioning

confidence: 99%

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Gruber

Bader

Holland

2014

The Journal of the Acoustical Society of America

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“…However, the large amplitude vibration regime is of importance for cases where a non-linear response of contrast agents is wished in order to discriminate them from the surrounding tissue. In addition to non-linear elasticity 7 , two processes can lead to a strong non-linear response: buckling 8 or destruction of the coating 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Buckling resistance of solid shell bubbles under ultrasound

Marmottant

Bouakaz

Jong

et al. 2011

The Journal of the Acoustical Society of America

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Thin solid shell contrast agents bubbles are expected to undergo different volume oscillating behaviors when the acoustic power is increased: small oscillations when the shell remains spherical, and large oscillations when the shell buckles. Contrary to bubbles covered with thin lipidic monolayers that buckle as soon as compressed, solid shell bubbles resist compression, making the buckling transition abrupt. Numerical simulations that explicitly incorporate a shell bending modulus give the critical buckling pressure and post-buckling shape, and show the appearance of a finite number of wrinkles. These findings are incorporated in a model based on the concept of effective surface tension. This model compares favorably to experiments when adjusting two main parameters: the buckling tension and the rupture shell tension. The buckling tension provides a direct estimation of the acoustic pressure threshold at which buckling occurs.

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“…90 In their experiments, they introduced three insonation parameters, ie, acoustic pressure (0-1 mPa), pulse frequency (1, 2.25, 5, and 7.5 MHz) and pulse length (1-10 cycles). The percentage of the ultrasound contrast agent that survived decreased with decreasing pulse frequency and with increasing transmission acoustic pressure and pulse length.…”

Section: Exposure Parametersmentioning

confidence: 99%

Potential and problems in ultrasound-responsive drug delivery systems

Zhao¹,

Du²,

Lu³

et al. 2013

IJN

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Abstract:Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington's disease, thrombolysis, and disruption of the blood-brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.

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Effects of Acoustic Insonation Parameters on Ultrasound Contrast Agent Destruction

Cited by 41 publications

References 30 publications

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound

Buckling resistance of solid shell bubbles under ultrasound

Potential and problems in ultrasound-responsive drug delivery systems

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