Effects of acute and chronic antidepressant treatments on memory performance: a comparison between paroxetine and imipramine

Naudon, Laurent; Hotte, Maïté; Jay, Thérèse M.

doi:10.1007/s00213-006-0660-4

Cited by 44 publications

(30 citation statements)

References 46 publications

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“…and determined no impairment in combination with scopolamine. Our results are consistent with the results reported by Naudon et al, in which paroxetine did not impair memory in the radial arm maze test 62 . There are limited studies investigating the effect of SSRIs on learning and memory in certain brain regions such as the prefrontal cortex.…”

Section: Discussionsupporting

confidence: 94%

“…However, Kumar and Kullkarni suggested that fluoxetine did not exhibit any negative effect when administered alone, and furthermore reversed scopolamine-induced impairment in a passive avoidance task 26 . Chronically paroxetine-treated rats exhibited no negative effect on memory in the delayed spatial win-shift test, and it has been suggested that this effect of paroxetine was related to brain regions such as the hippocampus and prefrontal cortex, which play a critical role in memory 62 . These inconsistent results of SSRIs on memory may be due to the use of different models.…”

Section: Discussionmentioning

confidence: 99%

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Improving Effect of Atomoxetine and Reboxetine on Memory in Passive Avoidance Task

Yüce

İlkaya

Karabekiroğlu

et al. 2014

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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ÖZET:Atomoksetin ve reboksetinin pasif sakınma testinde bellek üzerindeki iyileştirici etkisi Amaç: Serotonin ve/veya noradrenalin geri alım inhibitörlerinin bellek üzerine etkileri çeşitli klinik ve preklinik çalışmalarda araştırılmıştır. Ancak, çelişkili sonuçlar bildirilmiştir. Bu çalışmada selektif noradrenalin geri alım inhibitörü olan atomoksetin ve reboksetinin; serotonin geri alım inhibitörü olan paroksetinin ve trisiklik antidepresan amitriptilinin farelerde bellek üzerindeki etkileri pasif sakınma testi ile karşılaştırılmalı olarak değerlendirilmiştir. Yöntem: Çalışmada 25-30 gr ağırlığında erkek Balb-C fareler kullanıldı. Reboksetin (10 mg/kg), atomoksetin (5 mg/kg), paroksetin (10 mg/kg) ve amitriptilin (10 mg/kg) tek başlarına ve skopolamin (1 mg/kg) ile kombinasyon şeklinde uygulandı. Belleği değerlendirmek için pasif sakınma testi kullanıldı. İlk gün farelerin kazanım süresi (acquisition time) ikinci gün (24 saat sonra) ise retansiyon süresi (retention time) kaydedildi. Tüm ilaçlar ve salin, retansiyon süresinin değerlendirilmesinden 30 dakika önce intraperitoneal olarak uygulandı. Bulgular: Tüm ilaçlar ve salin, tek başlarına uygulandıklarında retansiyon süresini bozmadılar. Ancak, skopolamin retansiyon süresini anlamlı ölçüde bozdu (p=0.003). Skopolamin ile kombine edildiğinde reboksetin, atomoksetin ve paroksetin retansiyon süresinde belirgin bir iyileştirici etki gösterdi. Amitriptilin, skopolamin ile kombine edildiğinde retansiyon süresi anlamlı ölçüde azaldı (p=0.013). Sonuç: Atomoksetin ve reboksetinin bellek bozukluğu üzerindeki iyileştirici etkisi noradrenalin gerialım inhibisyonuna bağlı olabileceği ileri sürülebilir. Bellek bozukluğu üzerinde paroksetinin iyileştirici etkisi artmış serotonerjik aktivite ile ilişkili olabilir. Amitriptilinin bellek bozukluğu üzerinde iyileştirici etkisinin olmaması antikolinerjik yan etkisi nedeniyle olabilir. Bu ilaçların iyileştirici etkilerinin mekanizmalarını açıklamak için aynı model ve hayvan türlerini kullanarak yapılacak daha ileri çalışmalara ihtiyaç vardır. Improving effect of atomoxetine and reboxetine on memory in passive avoidance task Objective: The effects of serotonin and/or noradrenaline re-uptake inhibitors on memory have been investigated in various clinical and pre-clinical studies. However, contradictory results have been reported. In this study, the effect of the selective noradrenaline re-uptake inhibitors atomoxetine and reboxetine, a tricyclic antidepressant, amitriptyline, and a selective serotonin re-uptake inhibitor, paroxetine, on learning and memory were examined alone or in combination with scopolamine in mice using a passive avoidance task. Methods: Male Balb-C mice (25-30 g) were used. Reboxetine (10 mg/kg), atomoxetine (5 mg/kg), paroxetine (10 mg/kg) and amitriptyline (10 mg/ kg) were investigated alone or in combination with scopolamine (1 mg/kg). A passive avoidance task was used to evaluate memory function. Acquisition time was recorded on the first day and retention time on the second (after 24 h). All drugs and sal...

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Improving Effect of Atomoxetine and Reboxetine on Memory in Passive Avoidance Task

Yüce

İlkaya

Karabekiroğlu

et al. 2014

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…Cells were pretreated with antagonists for 30 min before addition of agonist. Imipramine hydrochloride (10 mg/kg; Sigma) (Naudon et al, 2007) or vehicle was administered daily to rats by intraperitoneal injections for 21 d and tissue was collected 1 d after the last injection.…”

Section: Methodsmentioning

confidence: 99%

The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus

Krol²,

et al. 2007

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Brain-derived neurotrophic factor (BDNF) is upregulated in the hippocampus by antidepressant treatments, and BDNF produces antidepressant-like effects in behavioral models of depression. In our previous work, we identified genes induced by BDNF and defined their specific roles in hippocampal neuronal development and plasticity. To identify genes downstream of BDNF that may play roles in psychiatric disorders, we examined a subset of BDNF-induced genes also regulated by 5-HT (serotonin), which includes the neuropeptide VGF (nonacronymic). To explore the function of VGF in depression, we first investigated the expression of the neuropeptide in animal models of depression. VGF was downregulated in the hippocampus after both the learned helplessness and forced swim test (FST) paradigms. Conversely, VGF infusion in the hippocampus of mice subjected to FST reduced the time spent immobile for up to 6 d, thus demonstrating a novel role for VGF as an antidepressant-like agent. Recent evidence indicates that chronic treatment of rodents with antidepressants increases neurogenesis in the adult dentate gyrus and that neurogenesis is required for the behavioral effects of antidepressants. Our studies using

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“…In the future, examining the effects of LY379268 on a TM task designed such that memory of the control animals is poor may reveal effects as previous results with object recognition have shown enhanced memory following LY379268 treatment (1 mg/kg) under such conditions [24]. Extending the delay between the sample trials and the test trial may produce a suitably poor TM in control rats [35].…”

Section: Discussionmentioning

confidence: 97%

Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268

Lins¹,

Ballendine²,

Howland³

2014

Neuroscience Letters

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Temporal order memory refers to the ability to distinguish past experiences in the order that they occurred. Temporal order memory for objects is often tested in rodents using spontaneous object recognition paradigms. The circuitry mediating memory in these tests is distributed and involves ionotropic glutamate receptors in the perirhinal cortex and medial prefrontal cortex. It is unknown what role, if any, metabotropic glutamate receptors have in temporal order memory for objects. The present experiment examined the role of metabotropic glutamate receptors in temporal memory retrieval using the group II metabotropic glutamate receptor selective agonist LY379268. Rats were trained on a temporal memory test with three phases: two sample phases (60 min between them) in which rats explored two novel objects and a test phase (60 min after the second sample phase) which included a copy of each object previously encountered. Under these conditions, we confirmed that rats showed a significant exploratory preference for the object presented during the first sample phase. In a second experiment, we found that LY379268 (0.3, 1.0, or 3.0 mg/kg; i.p.; 30 min before the test phase) had no effect on temporal memory retrieval but dose-dependently reduced time spent exploring the objects. Our results show that enhancing mGluR2 activity under conditions when TM is intact does not influence memory retrieval.

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Effects of acute and chronic antidepressant treatments on memory performance: a comparison between paroxetine and imipramine

Abstract: In contrast to the persistent harmful effects of imipramine, chronic treatment with paroxetine does not alter spatial working memory performance and appears to improve temporal order memory performance.

Cited by 44 publications

References 46 publications

Improving Effect of Atomoxetine and Reboxetine on Memory in Passive Avoidance Task

Improving Effect of Atomoxetine and Reboxetine on Memory in Passive Avoidance Task

The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus

Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268

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