Effects of acute hypotension on expression of cFos-like protein in the vestibular nuclei of rats

Kim, Min Sun; Kim, Jae Hyo; Kry, Davy; Choi, Myoung Ae; Choi, Dong Ok; Cho, Byung Gon; Jin, Yuan; Lee, Seong Ho; Park, Byung Rim

doi:10.1016/s0006-8993(02)03977-x

Cited by 22 publications

(22 citation statements)

References 40 publications

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“…Het mice lack otoconia in the two gravity-sensing organs of their inner ear, the utricle and saccule, preventing them from experiencing gravity or linear acceleration (3,26). Therefore, in the present study, based on the findings of Kim et al (29), one would expect c-Fos labeling in the vestibular nuclei of wild-type mice but not in het mice after BP manipulations. However, our results do not confirm this expectation.…”

Section: Discussionmentioning

confidence: 53%

“…Several experimental studies have demonstrated that hypertension and hypotension elicits the expression of c-Fos protein in several forebrain and brain stem nuclei affecting cardiovascular function (29,31,35). In the present study, the significant increases in c-Fos expression occur in the area postrema, NTS, VLM, supraoptic nucleus, and paraventricular nucleus after acute BP changes (increase or decrease) in wild-type and het mice, which are consistent with those of previous observations (29,31). However, the immunohistochemical results also indicate that BP manipulations alone do not produce differences in c-Fos expression in the vestibular nuclei of either group.…”

Section: Discussionmentioning

confidence: 99%

“…However, the immunohistochemical results also indicate that BP manipulations alone do not produce differences in c-Fos expression in the vestibular nuclei of either group. Recently, Kim et al (29) reported that c-Fos-like immunoreactive neurons were expressed bilaterally in vestibular nuclei after acute hypotension in normal but not bilaterally labyrinthectomized, anesthetized rats. On the basis of these findings, the authors suggested that peripheral vestibular receptors are essential for neuronal activation in vestibular nuclei after acute changes in BP.…”

Section: Discussionmentioning

confidence: 99%

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Diminished baroreflex control of heart rate responses in otoconia-deficient C57BL/6JEi head tilt mice

Xue

Skala

Jones

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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The maintenance of stable blood pressure during postural changes is known to involve integration of vestibular and cardiovascular central regulatory mechanisms. Sensory activity in the vestibular system plays an important role in cardiovascular regulation. The purpose of this study was to determine the role of vestibular gravity receptors in normal baroreflex function. Baroreflex heart rate (HR) responses to changes in blood pressure (BP) in otoconia-deficient head tilt (het) mice (n = 8) were compared with their wild-type littermates (n = 12). The study was carried out in conscious male mice chronically implanted with arterial and venous catheters for recording BP and HR and for the infusion of vasoactive drugs. Resting HR was higher in the het mice (661 +/- 13 beats/min) than in the wild-type mice (579 +/- 20 beats/min). BP was comparable in the het (113 +/- 4 mmHg) and wild-type mice (104 +/- 4 mmHg). The slopes of reflex decreases in HR in response to phenylephrine (PE) were blunted in the het mice (-5.5 +/- 1.5 beats x min(-1) x mmHg(-1)) compared with the wild-type mice (-8.5 +/- 0.9 beats x min(-1) x mmHg(-1)). Likewise, reflex tachycardic responses to decreases in BP with sodium nitroprusside (SNP) were significantly blunted in the het mice (-0.8 +/- 0.3 beats x min(-1) x mmHg(-1)) versus the wild-type mice (-2.2 +/- 0.6 beats x min(-1) x mmHg(-1)). Frequency-domain analysis of the HR variability suggests that under resting conditions, parasympathetic contribution was lower in the het versus wild-type mice. Mapping of the expression of immediate-early gene product, c-Fos, in forebrain and brain stem nuclei in response to a BP challenge showed no differences between the wild-type and het mice. These results suggest that tonic activity of gravity receptors modulates and is required for normal function of the cardiac baroreflexes.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diminished baroreflex control of heart rate responses in otoconia-deficient C57BL/6JEi head tilt mice

Xue

Skala

Jones

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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“…We used immunohistochemical labeling of pERK as a means of identifying the populations of neurons within the vestibular nuclei following deafferentation of the vestibular system [17]. Moreover, previous studies in our laboratory showed that sodium nitroprusside (SNP)-induced acute hypotension increases expression of c-Fos protein [18] and pERK [19] in the vestibular nuclei, and that these effects are abolished by removal of peripheral vestibular receptors.…”

Section: Introductionmentioning

confidence: 99%

Effect of Vestibulosympathetic Reflex and Baroreflex on Expression of pERK in the Nucleus Tractus Solitarius following Acute Hypotension in Conscious Rats

Jian

Jin

et al. 2014

Korean J Physiol Pharmacol

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Control of blood pressure is maintained by the interaction between the arterial baroreflex and vestibulosympathetic reflex during postural changes. In this study, the contributions of vestibular receptors and baroreceptors to the maintenance of blood pressure following acute hypotension were compared in terms of phosphorylated extracellular regulated protein kinase (pERK) expression in the nucleus tractus solitaries (NTS). Expression of pERK in the NTS was measured in conscious rats that had undergone bilateral labyrinthectomy (BL) and/or sinoaortic denervation (SAD) 5, 10, 20, and 40 min following acute hypotension induced by sodium nitroprusside (SNP) infusion. Expression of pERK increased significantly in the NTS in the control group following SNP infusion, and the expression peaked at 10 min after SNP infusion. The number of pERK positive neurons increased following SNP infusion in BL, SAD, and BL+SAD groups, although the increase was smaller than in control group. The BL group showed a relatively higher reduction in pERK expression than the SAD group, and the pERK expression in the NTS was localized to the caudal portion of the nuclei in the BL and SAD groups. These results suggest that the vestibular receptors may play a key role in maintaining blood pressure following acute hypotension; thus, the vestibular system may contribute to compensate for orthostatic hypotension.

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“…Abnormal placental development, placental injury, or both, associate with preterm birth, hypertensive disorders, central nervous system injury, and intrauterine growth restriction (22,44). Among all the pregnancies worldwide, ϳ5-10% result in suboptimal outcomes due to placental dysfunction.…”

mentioning

confidence: 99%

Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts

Chen¹,

Tuuli²,

Longtine³

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

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The human placenta is key to pregnancy outcome, and the elevated oxidative stress present in many complicated pregnancies contributes to placental dysfunction and suboptimal pregnancy outcomes. We tested the hypothesis that pomegranate juice, which is rich in polyphenolic antioxidants, limits placental trophoblast injury in vivo and in vitro. Pregnant women with singleton pregnancies were randomized at 35∼38 wk gestation to 8 oz/day of pomegranate juice or apple juice (placebo) until the time of delivery. Placental tissues from 12 patients (4 in the pomegranate group and 8 in the control group) were collected for analysis of oxidative stress. The preliminary in vivo results were extended to oxidative stress and cell death assays in vitro. Placental explants and cultured primary human trophoblasts were exposed to pomegranate juice or glucose (control) under defined oxygen tensions and chemical stimuli. We found decreased oxidative stress in term human placentas from women who labored after prenatal ingestion of pomegranate juice compared with apple juice as control. Moreover, pomegranate juice reduced in vitro oxidative stress, apoptosis, and global cell death in term villous explants and primary trophoblast cultures exposed to hypoxia, the hypoxia mimetic cobalt chloride, and the kinase inhibitor staurosporine. Punicalagin, but not ellagic acid, both prominent polyphenols in pomegranate juice, reduced oxidative stress and stimulus-induced apoptosis in cultured syncytiotrophoblasts. We conclude that pomegranate juice reduces placental oxidative stress in vivo and in vitro while limiting stimulus-induced death of human trophoblasts in culture. The polyphenol punicalagin mimics this protective effect. We speculate that antenatal intake of pomegranate may limit placental injury and thereby may confer protection to the exposed fetus.

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Effects of acute hypotension on expression of cFos-like protein in the vestibular nuclei of rats

Cited by 22 publications

References 40 publications

Diminished baroreflex control of heart rate responses in otoconia-deficient C57BL/6JEi head tilt mice

Diminished baroreflex control of heart rate responses in otoconia-deficient C57BL/6JEi head tilt mice

Effect of Vestibulosympathetic Reflex and Baroreflex on Expression of pERK in the Nucleus Tractus Solitarius following Acute Hypotension in Conscious Rats

Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts

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