Effects of acute nicotine on auditory change-related cortical responses

Otsuru, Naofumi; Tsuruhara, Aki; Motomura, Eishi; Tanii, Hisashi; Nishihara, Makoto; Inui, Koji; Kakigi, Ryusuke

doi:10.1007/s00213-012-2757-2

Cited by 25 publications

(34 citation statements)

References 49 publications

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“…In addition, nicotine's effects on response amplitude were negatively correlated with the baseline amplitude of the response. All the results are similar to those in our previous study on the auditory change-related N1 response (Otsuru et al, 2012), suggesting that the effect of nicotine is common across the sensory systems. One possible explanation for the discrepancy in nicotine's effects on S1, S2, and iS2 is the different roles Fig.…”

Section: Discussionsupporting

confidence: 90%

“…The present results show a significant impact of nicotine on somatosensory change-related cortical responses similar to the auditory (Harkrider and Hedrick, 2005;Inami et al, 2005;Baldeweg et al, 2006;Dunbar et al, 2007;Martin et al, 2009;Otsuru et al, 2012) and visual systems. In addition, nicotine's effects on response amplitude were negatively correlated with the baseline amplitude of the response.…”

Section: Discussionmentioning

confidence: 78%

“…1C). Then the location and orientation were averaged across runs, and the averaged model was applied to all the data as described previously (Otsuru et al, 2012). The obtained source strength waveform was used to evaluate the peak latency and amplitude of each cortical response (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Positive effects of a selective nAChR agonist on auditory MMN also have been shown in healthy male subjects (Dunbar et al, 2007). Recently, we demonstrated enhancing effects of nicotine on the auditory change-detection system using magnetoencephalography (MEG) (Otsuru et al, 2012). These findings imply that the effects of nicotine on the automatic change-detecting system are common across sensory modalities.…”

Section: Introductionmentioning

confidence: 93%

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Effects of acute nicotine on somatosensory change-related cortical responses

et al. 2013

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

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Effects of acute nicotine on somatosensory change-related cortical responses

et al. 2013

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“…Several neuroscientific studies investigating nicotine's effects on auditory perception have confirmed nicotine's ability to enhance arousal and attention using functional magnetic resonance imagining F o r P e e r R e v i e w 4 (fMRI) (Smucny et al, 2015;Thiel & Fink, 2007) and magnetencephalography (MEG) (Otsuru et al, 2012). Electrophysiological techniques, for example Event+Related Potentials (ERPs), have also supported nicotine's role as an enhancer of arousal and attention (Harkrider & Champlin, 2001).…”

mentioning

confidence: 96%

Nicotine enhances an auditory Event-Related Potential component which is inversely related to habituation

2017

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Nicotine is a psychoactive substance that is commonly consumed in the context of music.However, the reason why music and nicotine are co+consumed is uncertain. One possibility is that nicotine affects cognitive processes relevant to aspects of music appreciation in a beneficial way. Here we investigated this possibility using Event+ Related Potentials (ERPs). Participants underwent a simple decision+making task (to maintain attentional focus), responses to which were signaled by auditory stimuli. Unlike previous research looking at the effects of nicotine on auditory processing, we used complex tones that varied in pitch, a fundamental element of music. In addition, unlike most other studies, we tested non+smoking subjects to avoid withdrawal+related complications. We found that nicotine (4.0 mg, administered as gum) increased P2 amplitude in the frontal region. Since a decrease in P2 amplitude and latency is related to habituation processes, and an enhanced ability to disengage from irrelevant stimuli, our findings suggest that nicotine may cause a reduction in habituation, resulting in non+ smokers being less able to adapt to repeated stimuli. A corollary of that decrease in adaptation may be that nicotine extends the temporal window during which a listener is able and willing to engage with a piece of music.

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Auditory change‐related cortical response is associated with hypervigilance to pain in healthy volunteers

Otsuru

Ogawa

Yokota

et al. 2021

European Journal of Pain

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Background: Patients with chronic pain exhibit hypervigilance (heightened responsiveness to stimuli) to innocuous auditory stimuli as well as noxious stimuli."Generalized hypervigilance" suggests that individuals who show heightened responsiveness to one sensory system also show hypervigilance to other modalities. However, research exploring the existence of generalized hypervigilance in healthy subjects is limited.Methods: We investigated whether hypervigilance to pain is associated with auditory stimuli in healthy subjects using the pain vigilance and awareness questionnaire (PVAQ) and auditory change-related cortical responses (ACRs). ACRs are thought to reflect a change detection system, based on preceding sensory memory. We recorded ACRs under conditions that varied in terms of the accumulation of sensory memory as follows: short-ACR, with short preceding continuous stimuli and long-ACR, with long preceding continuous stimuli. In addition, the attention to pain (PVAQ-AP) and attention to changes in pain (PVAQ-ACP) subscales were evaluated.Results: Amplitudes of long-ACR showed significant positive correlations with PVAQ-ACP, whereas those of short-ACR did not show any significant correlations. Conclusions: Generalized hypervigilance may be observed even in healthy subjects. ACR may be a useful index to evaluate the hypervigilance state in the human brain.

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Effects of acute nicotine on auditory change-related cortical responses

Abstract: Since Change-N1m represents a pre-attentive automatic process to encode new auditory events, the present results suggest that nicotine can exert beneficial cognitive effects without a direct impact on attention.

Cited by 25 publications

References 49 publications

Effects of acute nicotine on somatosensory change-related cortical responses

Effects of acute nicotine on somatosensory change-related cortical responses

Nicotine enhances an auditory Event-Related Potential component which is inversely related to habituation

Auditory change‐related cortical response is associated with hypervigilance to pain in healthy volunteers

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