Effects of acute oral feeding on protein metabolism and muscle protein synthesis in individuals with cancer

Meij, Barbara S. van der; Groot, Lynette M. De; Deutz, Nicolaas E. P.; Engelen, M.P.

doi:10.1016/j.nut.2019.06.012

Cited by 6 publications

(2 citation statements)

References 52 publications

(48 reference statements)

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“…Several studies showed the effect of branched-chain amino acids (BCAAs) on muscle protein metabolism, among which leucine has been studied the most [60]. It has been suggested that leucine supplementation can impact protein turnover by activating the mTOR pathway, leading to upregulation of protein translation, and reducing muscle protein degradation during CC [61][62][63].…”

Section: Role Of Amino Acids In Combatting Cancer Cachexia-induced In...mentioning

confidence: 99%

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Pradhan,

Dieterich,

Natarajan

et al. 2024

Cancers

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Cancer cachexia is a multifaceted syndrome that impacts individuals with advanced cancer. It causes numerous pathological changes in cancer patients, such as inflammation and metabolic dysfunction, which further diminish their quality of life. Unfortunately, cancer cachexia also increases the risk of mortality in affected individuals, making it an important area of focus for cancer research and treatment. Several potential nutritional therapies are being tested in preclinical and clinical models for their efficacy in improving muscle metabolism in cancer patients. Despite promising results, no special nutritional therapies have yet been validated in clinical practice. Multiple studies provide evidence of the benefits of increasing muscle protein synthesis through an increased intake of amino acids or protein. There is also increasing evidence that exercise can reduce muscle atrophy by modulating protein synthesis. Therefore, the combination of protein intake and exercise may be more effective in improving cancer cachexia. This review provides an overview of the preclinical and clinical approaches for the use of amino acids with and without exercise therapy to improve muscle metabolism in cachexia.

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Section: Role Of Amino Acids In Combatting Cancer Cachexia-induced In...mentioning

confidence: 99%

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Pradhan,

Dieterich,

Natarajan

et al. 2024

Cancers

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“…A shift in the balance between protein breakdown and protein synthesis is seen in the CACS. The etiology can be attributed to the cause of proteolysis-inducing factor (PIF) (9,(22)(23)(24). Studies have shown that PIF is found in the urine of patients with this syndrome and further studies in this area are important.…”

Section: Changes In Protein Metabolismmentioning

confidence: 99%

Cachexia and anorexia in cancer; a systematic review

Darakhshandeh

Momenzadeh

2020

Immunopathol Persa

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The treatment strategy for cancer cachexia is based on the cachexia stage of the cancer and its phenotypes, therefore interventions and expected outcomes vary. In order for the patient to get the most out of the treatment, it should be done based on the mechanism of intervention and the quality of life of patients should be addressed, including aspects of rehabilitation and reduction of the patient’s suffering using a multidisciplinary team. Given the importance of the subject, the present study aims to investigate cachexia and anorexia in cancer. From the electronic databases, PubMed, Cochrane Library, Embase, Web of Sciences have been used to perform a systematic literature until 2020. Therefore, a software program (Endnote X8) has been utilized for managing electronic titles. Searches were performed with mesh terms. This review recommended that clinicians establish an interaction between cancer anorexia-cachexia syndrome (CACS) treatments and chronic pain treatments and choose the best treatment option.

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Prognostic value of sarcopenia in survivors of hematological malignances undergoing a hematopoietic stem cell transplantation: a systematic review and meta-analysis

Jia

Qiao

Xiao

et al. 2020

Support Care Cancer

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Effects of acute oral feeding on protein metabolism and muscle protein synthesis in individuals with cancer

Cited by 6 publications

References 52 publications

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia

Cachexia and anorexia in cancer; a systematic review

Prognostic value of sarcopenia in survivors of hematological malignances undergoing a hematopoietic stem cell transplantation: a systematic review and meta-analysis

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