Cachexia and anorexia in cancer; a systematic review

Darakhshandeh, Ali; Momenzadeh, Mahnaz

doi:10.34172/ipp.2021.20

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…Within the tumor microenvironment, signaling occurs between tumor cells and a variety of other cell types. The development of pro-angiogenic growth factors by tumor cells, which influence the existing vessels, is required to induce this mechanism [53][54][55].…”

Section: General Angiogenesismentioning

confidence: 99%

The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

Yang

Zhang

et al. 2023

Cancer Cell Int

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After skin malignancy, breast cancer is the most widely recognized cancer detected in women in the United States. Breast cancer (BCa) can happen in all kinds of people, but it's much more common in women. One in four cases of cancer and one in six deaths due to cancer are related to breast cancer. Angiogenesis is an essential factor in the growth of tumors and metastases in various malignancies. An expanded level of angiogenesis is related to diminished endurance in BCa patients. This function assumes a fundamental part inside the human body, from the beginning phases of life to dangerous malignancy. Various factors, referred to as angiogenic factors, work to make a new capillary. Expanding proof demonstrates that angiogenesis is managed by microRNAs (miRNAs), which are small non-coding RNA with 19–25 nucleotides. MiRNA is a post-transcriptional regulator of gene expression that controls many critical biological processes. Endothelial miRNAs, referred to as angiomiRs, are probably concerned with tumor improvement and angiogenesis via regulation of pro-and anti-angiogenic factors. In this article, we reviewed therapeutic functions of miRNAs in BCa angiogenesis, several novel delivery carriers for miRNA-based therapeutics, as well as CRISPR/Cas9 as a targeted therapy in breast cancer.

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Section: General Angiogenesismentioning

confidence: 99%

The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

Yang

Zhang

et al. 2023

Cancer Cell Int

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“…Furthermore, in Stoff Khalili et al research, hMSCs were utilized as intermediate vehicles for conditional replication oncolytic adenoviruses (CRAds) to target breast cancer and reduced the development of pulmonary metastasis, most likely due to viral replication in the hMSCs [ 90 ]. Pulmonary metastasis in patients with breast cancer is common characteristic [ 171 , 172 , 173 ] and is associated with lethal complications in these patients [ 174 , 175 ]. Furthermore, when CRAd-loaded MSC was given intravenously to mice with solid ovarian cancer, it had a considerably stronger anticancer impact and a prolonged survival time than CRAd delivered directly [ 89 ].…”

Section: Msc-based Delivery Of Oncolytic Adenovirus (Oads)mentioning

confidence: 99%

Mesenchymal stem cell-released oncolytic virus: an innovative strategy for cancer treatment

et al. 2023

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Oncolytic viruses (OVs) infect, multiply, and finally remove tumor cells selectively, causing no damage to normal cells in the process. Because of their specific features, such as, the ability to induce immunogenic cell death and to contain curative transgenes in their genomes, OVs have attracted attention as candidates to be utilized in cooperation with immunotherapies for cancer treatment. This treatment takes advantage of most tumor cells' inherent tendency to be infected by certain OVs and both innate and adaptive immune responses are elicited by OV infection and oncolysis. OVs can also modulate tumor microenvironment and boost anti-tumor immune responses. Mesenchymal stem cells (MSC) are gathering interest as promising anti-cancer treatments with the ability to address a wide range of cancers. MSCs exhibit tumor-trophic migration characteristics, allowing them to be used as delivery vehicles for successful, targeted treatment of isolated tumors and metastatic malignancies. Preclinical and clinical research were reviewed in this study to discuss using MSC-released OVs as a novel method for the treatment of cancer.

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“…By increasing the expression of TNF-related apoptosis inducing ligand (TRAIL) and TRAIL receptors, such as DR4 and DR5 on the surface of cancer cells, chemotherapy drugs increase Caspase8; subsequently, it induces apoptosis. Therefore, it can play a positive role in the process of treatment with chemotherapy drugs [ 29 – 31 ].…”

Section: Tumor Necrosis Factor-alpha (Tnf-α)mentioning

confidence: 99%

The effect of COVID-19 derived cytokine storm on cancer cells progression: double-edged sword

et al. 2021

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Objective Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) was first detected in Wuhan, China in December, 2019. The emerging virus causes a respiratory illness, that can trigger a cytokine storm in the body. Method Cytokine storm in patient’s body is associated with severe forms of disease. It is one of the main complications of coronavirus disease-2019 (COVID-19), in which immune cells play a major role. Studies have shown immune cells in the tumor environment can be effective to induce resistance to chemotherapy in cancer patients. Result Therefore, considering the role of immune cells to induce cytokine storm in COVID-19 patients, and their role to cause resistance to chemotherapy, they are effective on disease progression and creation of severe form of disease. Conclusion By examining the signaling pathways and inducing resistance to chemotherapy in tumor cells and the cells affect them, it is possible to prevent the occurrence of severe forms of the disease in cancer patients with COVID-19; it is applicable using target therapy and other subsequent treatment strategies.

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Cachexia and anorexia in cancer; a systematic review

Cited by 3 publications

References 26 publications

The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

Mesenchymal stem cell-released oncolytic virus: an innovative strategy for cancer treatment

The effect of COVID-19 derived cytokine storm on cancer cells progression: double-edged sword

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