The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

Abstract

After skin malignancy, breast cancer is the most widely recognized cancer detected in women in the United States. Breast cancer (BCa) can happen in all kinds of people, but it's much more common in women. One in four cases of cancer and one in six deaths due to cancer are related to breast cancer. Angiogenesis is an essential factor in the growth of tumors and metastases in various malignancies. An expanded level of angiogenesis is related to diminished endurance in BCa patients. This function assumes a fundamental part inside the human body, from the beginning phases of life to dangerous malignancy. Various factors, referred to as angiogenic factors, work to make a new capillary. Expanding proof demonstrates that angiogenesis is managed by microRNAs (miRNAs), which are small non-coding RNA with 19–25 nucleotides. MiRNA is a post-transcriptional regulator of gene expression that controls many critical biological processes. Endothelial miRNAs, referred to as angiomiRs, are probably concerned with tumor improvement and angiogenesis via regulation of pro-and anti-angiogenic factors. In this article, we reviewed therapeutic functions of miRNAs in BCa angiogenesis, several novel delivery carriers for miRNA-based therapeutics, as well as CRISPR/Cas9 as a targeted therapy in breast cancer.

Synthesis and evaluation of chitosan/miR-125b nanoparticles for targeting Raf-1 and BMPR1b genes in MCF-7 breast cancer cells

“…MiR-125b is a tumor suppressor miRNA that is frequently downregulated in breast cancer and targets several oncogenes, such as Raf-1 and BMPR1b [19]. However, the delivery of miRNAs to tumor cells is challenging due to their instability, low cellular uptake, and off-target effects [20]. In this study, we developed and evaluated chitosan/miR-125b nanoparticles (CNPs) as a novel carrier for miR-125b delivery to MCF-7 breast cancer cells.…”

Emerging Epigenetic Targets and Their Molecular Impact on Vascular Remodeling in Pulmonary Hypertension

“…MiRNAs, short single-stranded non-coding RNAs with total lengths ranging from 19 to 25 nucleotides, exert control over gene expression by triggering translational repression via fast mRNA degradation with deadenylation. MicroRNAs that target angiogenic factors such as VEGF-A (miR-128, miR-200b) are downregulated in [58][59][60], but MicroRNAs that target anti-angiogenic factors (miR-221/222 cluster, miR-210) are elevated. These epigenetic alterations imply that PH maybe linked to lung cancer.…”

Correction: The various role of microRNAs in breast cancer angiogenesis, with a special focus on novel miRNA-based delivery strategies

“…In this article [ 1 ], the grant number was not stated. The acknowledgment to be amended as follows: The research is supported by the Science and Technology Research Project from the Education Department of Jilin Province, Based on the NF-κB mediated inflammatory corpuscle and PI3K/AKT signaling pathway research puerarin drug mechanism of nanometer fiber membrane on the skin wound healing (No.…”