Effects of addition of fluorine in diets differing in protein content on urinary fluoride excretion, clinical chemistry and thyroid hormones in calves

Abstract

-In order to compare the effects of addition of fluorine (F) in diets differing in protein content on the urinary F excretion, blood profile and thyroid hormones, 30 crossbred calves (6-8 months) initially exposed to different protein levels were allotted into six groups in a 3 × 2 factorial design. The factors included three different levels of protein: normal (NP; 100%), low (LP; 75%), and high (HP; 125%) besides two levels of supplemental fluorine (as sodium fluoride) at 0 or 200 mg/kg diet. The animals were fed a wheat straw-based diet for 210 d. Feeding NP diets decreased urinary fluoride excretion, measured at 42 d intervals, compared with LP diets. Blood levels of hemoglobin and haematocrit, measured at 70 d intervals, were not affected by either protein or fluorine levels, but period differences were apparent. Serum levels of urea, alkaline phosphatase and F showed greater increase in groups supplemented with F than in those without it; however, serum calcium was higher in the latter. Serum tri-iodo-thyronine and thyroxine levels were higher in HP and NP fed calves than animals on LP diets, respectively. The animals fed LPF have higher urinary F as compared with animals fed NPF, but were not different from the group fed HPF. The blood and serum variables indicated that there is no extra protection against susceptibility to F toxicity upon feeding of 25 percent higher protein than requirements.

An interventional clinical trial investigating the effects of Spirulina platensis on dental fluorosis and antioxidant system in lambs reared in endemic areas

“…This substantial presence of crude proteins holds significance as it suggests Spirulina platensis may contribute to overall protein intake in animals. This aspect potentially plays a role in mitigating the adverse effects of fluoride toxicity on protein synthesis 43 , 44 . Furthermore, the findings of the current study revealed that the fluoride excretion level via feces was the same in all studied groups.…”