2012
DOI: 10.3109/03008207.2012.660585
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Effects of Adipose Tissue Stem Cell Concurrent with Greater Omentum on Experimental Long-Bone Healing in Dog

Abstract: Repair of large bone defects resulting from trauma, tumors, and osteitis is a current challenge to surgeons. Adipose-derived adult stem cells (ASCs) are multipotent cells that are able to differentiate into osteoblasts in the presence of certain factors. In this study, the role of greater omentum as a scaffold incorporation of ASCs was evaluated in long-bone defect healing in dog model. Sixteen 3-4-year-old, male adult mongrel dogs, weighing 25.2 ± 3.5 kg, were used in this study. In the control group (n = 4),… Show more

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Cited by 35 publications
(28 citation statements)
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“…The main adipose tissue harvest areas in previous studies in dogs are the falciform ligament [35], lateral thoracic area [36], caudal scapular region [37], intra-abdominal or subcutaneous fat obtained during ovariohysterectomy surgery [38,39] gluteal fat [40], and inguinal region [41,42]. In the current study fat was harvested from the inguinal area due to easy surgical access, the abundant collection and discrete scarring with no postoperative complications in any patients.…”
Section: Resultsmentioning
confidence: 99%
“…The main adipose tissue harvest areas in previous studies in dogs are the falciform ligament [35], lateral thoracic area [36], caudal scapular region [37], intra-abdominal or subcutaneous fat obtained during ovariohysterectomy surgery [38,39] gluteal fat [40], and inguinal region [41,42]. In the current study fat was harvested from the inguinal area due to easy surgical access, the abundant collection and discrete scarring with no postoperative complications in any patients.…”
Section: Resultsmentioning
confidence: 99%
“…Various adipose tissue donor sites have been reported in revised literature: retroperitoneal adipose tissue [27], lateral thoracic area [28], gluteous fat [29] or inguinal region [8,30]. The authors preferred this location to others for its easier access, abundant quantities of fat, absence of surgical complications and production of a non-visible scar.…”
Section: Discussionmentioning
confidence: 99%
“…Different adipose tissue donor sites have been found in revised literature: retroperitoneal adipose tissue [22], lateral thoracic area [23], gluteous fat [24] or inguinal region [5,25]. We preferred this location to others because it is easier to access, abundant quantities of fat, absence of surgical complications and production of a non visible scar.…”
Section: Discussionmentioning
confidence: 99%