Effects of AeDNV infection on Aedes aegypti lifespan and reproduction

Suchman, Erica; Kononko, A G; Plake, Emily; Doehling, Malena; Kleker, Brian; Black, William C.; Buchatsky, L.; Carlson, Jonathan O.

doi:10.1016/j.biocontrol.2006.05.001

Cited by 18 publications

(16 citation statements)

References 20 publications

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“…In particular, the use of Densovirus (Kittayapong et al 1999; Ledermann et al 2004; Carlson et al 2006; Suchman et al 2006), Wolbachia (McMeniman et al 2009; Read and Thomas 2009), or insecticide to increase mosquito background mortality has the same effect in our model as does the introduction of a dominant female-killing gene (Thomas et al 2000; Alphey and Andreasen 2002): these control strategies select for increased dengue virulence to mosquitoes (May and Anderson 1983; Kakehashi and Yoshinaga 1992; Lenski and May 1994; Ebert and Mangin 1997) and impose no selection on virulence to humans.…”

Section: Discussionmentioning

confidence: 95%

“…A transgene might be developed that causes mosquitoes to bite humans less frequently, perhaps only after the first blood meal or, optimally, on dengue infection. For increased mosquito background mortality, there are a variety of strategies, including the release of engineered males homozygous for a dominant female-killing gene (i.e., population reduction by elimination of female offspring; Thomas et al 2000; Alphey and Andreasen 2002), the introduction of mosquito-specific lethal Densovirus into the environment (Carlson et al 2006; Suchman et al 2006), the release of mosquitoes infected with life-shortening Wolbachia (McMeniman et al 2009; Read and Thomas 2009), and the use of insecticides. Viruses of the genus Densovirus are known to infect only insects, and several have been found that are environmentally and vertically transmitted in mosquitoes and cause high mortality (Kittayapong et al 1999; Ledermann et al 2004; Carlson et al 2006; Suchman et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Transgenic Mosquitoes on Dengue Virulence to Humans and Mosquitoes

Medlock

Luz²,

Struchiner³

et al. 2009

The American Naturalist

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Dengue is a major public health concern in the tropics and subtropics. Innovative transgenic strategies to render Aedes aegypti mosquitoes, the primary vector of dengue, incompetent for dengue transmission are under development. We modeled the evolutionary impact of different transgenic mosquito strategies on dengue-induced mortality, that is, dengue virulence, to both humans and mosquitoes. This model incorporates various evolutionary trade-offs in dengue virus epidemiological traits, for example, a trade-off between dengue transmission rate and its virulence to humans. Our results indicate that strategies that block transmission or reduce mosquito biting impose selection on dengue virulence in humans. This selection can be for either higher or lower virulence, depending on the interaction between the effect of the transgene and the trade-offs in epidemiological traits, highlighting the need for detailed quantitative data to understand more fully the impact of mosquito transgenesis on dengue virulence. Dengue virulence in mosquitoes can be selected on by transgenic strategies of blocking transmission, decreased mosquito biting, increased mosquito background mortality, and increased mosquito infection-induced mortality. Our results suggest that dengue control strategies that raise mosquito background mortality or mosquito infection-induced mortality pose less risk of causing increased virulence to humans than strategies that block transmission or reduce mosquito biting.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

The Impact of Transgenic Mosquitoes on Dengue Virulence to Humans and Mosquitoes

Medlock

Luz²,

Struchiner³

et al. 2009

The American Naturalist

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“…Interestingly, ambidensoviruses with different vertical transmission rates had different types of symbiotic interactions: while the 100% vertically transmitted ambidensovirus of H. armigera is mutualistic (Xu et al ., ), the Myzus persicae densovirus which is transmitted to 30%–40% of the offspring has been shown to affect its hosts adversely (Van Munster et al ., ). In mosquitoes experimentally infected with brevidensoviruses, the vertical transmission ranged between 28% to 62%: (i) for Aedes albopictus densovirus, the vertical transmission rate ranged between 28% and 55% depending on the virus titre in parental females (Barreau et al ., ); (ii) for Aedes aegypti densovirus vertical transmission ranged from 42% to 62% depending on the timing of the horizontal infection of the larvae (the larvae that were infected during L3 stage transmitted the virus less, as they became adults, than the larvae infected during L1 stage) (Suchman et al ., ) and (iii) for Aedes gambiae densovirus vertical transmission was detected in 28% of larval offspring (Ren et al ., ). We showed that CpDV was transmitted to an average of 17% of the larval offspring in naturally infected Cx.…”

Section: Discussionmentioning

confidence: 99%

“…The importance of interindividual variability in vertical transmission rate of CpDV revealed the complexity of the factors affecting vertical transmission. Individual differences in vertical transmission, for instance, could be due to when females have been infected by horizontal transmission (Suchman et al ., ), or whether they have been infected vertically or horizontally. Due to the lack of CpDV free lines, it was not possible to quantify the horizontal transmission or venereal transmission by experimental infections.…”

Section: Discussionmentioning

confidence: 99%

Sharing cells with Wolbachia: the transovarian vertical transmission of Culex pipiens densovirus

Altinli

Soms

Ravallec

et al. 2019

Environmental Microbiology

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Summary Culex pipiens densovirus (CpDV), a single stranded DNA virus, has been isolated from Culex pipiens mosquitoes but differs from other mosquito densoviruses in terms of genome structure and sequence identity. Its transmission from host to host, the nature of its interactions with both its host and host's endosymbiotic bacteria Wolbachia are not known. Here, we report the presence of CpDV in the ovaries and eggs of Cx. pipiens mosquitoes in close encounters with Wolbachia. In the ovaries, CpDV amount significantly differed between mosquito lines harbouring different strains of Wolbachia and these differences were not linked to variations in Wolbachia densities. CpDV was vertically transmitted in all laboratory lines to 17%–20% of the offspring. For some females, however, the vertical transmission reached 90%. Antibiotic treatment that cured the host from Wolbachia significantly decreased both CpDV quantity and vertical transmission suggesting an impact of host microbiota, including Wolbachia, on CpDV transmission. Overall our results show that CpDV is transmitted vertically via transovarian path along with Wolbachia with which it shares the same cells. Our results are primordial to understand the dynamics of densovirus infection, their persistence and spread in populations considering their potential use in the regulation of mosquito vector populations.

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“…Temperature and adult nutrient reserves (e.g., Nayar 1968; Nayar and Sauerman 1971a,b; 1975a,b,c; Alto and Juliano 2001; Delatte et al 2009; Paaijmans et al 2010; Vrzal et al 2010; Xue et al 2010; Lambrechts et al 2011; Alto and Bettinardi 2013) have long been known to affect mortality, and recent work has shown effects of pathogens (Suchman et al 2006, Dawes et al. 2009, Lambrechts and Scott 2009, McMeniman et al 2009) and mosquito age (Styer et al.…”

Section: Mosquito Mortalitymentioning

confidence: 99%

Can Horton Hear the Whos? The Importance of Scale in Mosquito-Borne Disease

et al. 2014

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The epidemiology of vector-borne pathogens is determined by mechanisms and interactions at different scales of biological organization, from individual-level cellular processes to community interactions between species and with the environment. Most research, however, focuses on one scale or level with little integration between scales or levels within scales. Understanding the interactions between levels and how they influence our perception of vector-borne pathogens is critical. Here two examples of biological scales (pathogen transmission and mosquito mortality) are presented to illustrate some of the issues of scale and to explore how processes on different levels may interact to influence mosquito-borne pathogen transmission cycles. Individual variation in survival, vector competence, and other traits affect population abundance, transmission potential, and community structure. Community structure affects interactions between individuals such as competition and predation, and thus influences the individual-level dynamics and transmission potential. Modeling is a valuable tool to assess interactions between scales and how processes at different levels can affect transmission dynamics. We expand an existing model to illustrate the types of studies needed, showing that individual-level variation in viral dose acquired or needed for infection can influence the number of infectious vectors. It is critical that interactions within and among biological scales and levels of biological organization are understood for greater understanding of pathogen transmission with the ultimate goal of improving control of vector-borne pathogens.

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Effects of AeDNV infection on Aedes aegypti lifespan and reproduction

Cited by 18 publications

References 20 publications

The Impact of Transgenic Mosquitoes on Dengue Virulence to Humans and Mosquitoes

The Impact of Transgenic Mosquitoes on Dengue Virulence to Humans and Mosquitoes

Sharing cells with Wolbachia: the transovarian vertical transmission of Culex pipiens densovirus

Can Horton Hear the Whos? The Importance of Scale in Mosquito-Borne Disease

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