Effects of aerobic exercise, resistance exercise or both, on patient-reported health status and well-being in type 2 diabetes mellitus: a randomised trial

Abstract

Aims/hypothesis The Diabetes Aerobic and Resistance Exercise (DARE) study showed that aerobic and resistance exercise training each improved glycaemic control and that a combination of both was superior to either type alone in patients with type 2 diabetes mellitus. Here we report effects on patient-reported health status and well-being in the DARE Trial. Methods We randomised 218 inactive participants with type 2 diabetes mellitus in parallel to 22 weeks of aerobic exercise (n=51), resistance exercise (n=58), combined aerobic and resistance exercise (n=57) or no exercise (control; n=52). Intervention allocation was managed by a central office. Outcomes included health status as assessed by the physical and mental component scores of the Medical Outcomes Trust Short-Form 36-item version (SF-36) and well-being as measured by the Well-Being Questionnaire 12-item version (WBQ-12); these were measured at the Ottawa Hospital. Results Using a p value of 0.0125 for statistical significance due to multiple comparisons, mixed model analyses indicated that resistance exercise led to clinically but not statistically significant improvements in the SF-36 physical component score compared with aerobic exercise (Δ=2.7 points; p=0.048) and control (i.e. no exercise; Δ=3.3 points; p=0.015). For mental component scores, there were clinically important improvements favouring no (control) compared with resistance (Δ=7.6 points; p<0.001) and combined (Δ=7.2 points; p<0.001) exercise. No effects on WBQ-12 scores were noted. Overall, 59/218 (27%) of participants included in this analysis sustained an adverse event during the course of the study, including 16 participants in the combined exercise group, 19 participants in the resistance exercise group, 16 participants in the Electronic supplementary material The online version of this article

Relationship of exercise volume to improvements of quality of life with supervised exercise training in patients with type 2 diabetes in a randomised controlled trial: the Italian Diabetes and Exercise Study (IDES)

“…Strengths of this study are that it was multicentre, thus less dependent on local factors, and of larger size and longer duration than other exercise intervention trials in patients with type 2 diabetes [24][25][26][27], including those assessing QoL and well-being measures [10][11][12][13].…”

“…From a long-term perspective, lifestyle modification might be better maintained if associated with improvement in quality of life (QoL), but results from previous trials investigating the impact of structured exercise counselling or supervised training on physical and mental health and well-being in diabetic patients are inconclusive [10][11][12][13].…”

Virtual Reality Exercise Improves Balance of Elderly Persons with Type 2 Diabetes: a Randomized Controlled Trial

“…Most previous researches of the elderly with diabetes has focused on improving glycemic control and lowering the risk of cardiovascular diseases through exercise intervention [11][12][13][14][15][16] , and only a few studies have dealt with enhancing balance. Therefore a systematic study of the effects of exercise on the balance of old adults with diabetes is needed 17) .…”

Tissue Storage of Dipeptides as Protein Guards Against Oxidative Injury in Patients with Type 2 Diabetes and Its Microvascular Complications

“…Carnosines are secreted into the circulation by skeletal muscle cells during physical exercise, which is in line with the beneficial effects of physical exercise on diabetic complications [17,18]. Our recent study shows that the kidney has its own carnosine metabolism [19].…”