Effects of age, sex and breed on antipyrine disposition in calves

Depelchin, B. O.; Bloden, Serge; Michaux, Charles; Ansay, Michel

doi:10.1016/s0034-5288(18)30828-2

Cited by 23 publications

(11 citation statements)

References 16 publications

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“…Strain and breed-related differences in CYP3A-mediated metabolism have already been demonstrated in man and rats as well [2,5,26,32]. As far as cattle are concerned, breed-differences in the disposition of antipyrine (a probe used in clinical pharmacology to determine the effects of individual or environmental factors on DME) have been reported in Blue White Belgian and Friesian calves [8]. Moreover, very recently some differences, at least in the catalytic activity level, were reported in both the oxidative and conjugative liver drug metabolism in PDM, Charolais and Blonde d'Aquitaine male cattle (Carletti et al, unpublished results).…”

Section: Discussionmentioning

confidence: 98%

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Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants

et al. 2005

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-The cytochrome P450 (P450) superfamily represents a group of relevant enzymes in the field of drug metabolism and several exogenous or constitutional factors contribute to regulate its expression. Cattle represent an important source of animal-derived food-products and studies concerning the P450 expression are needed for the extrapolation of pharmacotoxicological data from one species to another and for the evaluation of the consumer's risk associated with the consumption of harmful residues found in foodstuffs. In the present study, possible breed-, genderand species-differences in P4503A (the P450 subfamily more expressed in the human liver) expression were studied in vitro in Piedmontese (PDM) and Limousin (LIM) meat cattle breeds of both sexes and in domestic Ruminants (cattle, sheep and goats). Cytochrome P450 and P4503A contents as well as CYP3A-dependent drug metabolising enzymes (DME) were measured in liver microsomes. Significant lower levels of P450 (P < 0.001) and P4503A (P < 0.05) contents were observed in PDM vs. LIM of both sexes; the P4503A-dependent DME activities were significantly (P values ranging from 0.05 up to 0.001) higher in PDM cattle, particularly in males. A gendereffect in DME activities was noticed (P < 0.05) only in PDM male cattle. With regards to the species, the expression of both P4503A apoprotein and some of the related DME activities were more pronounced in sheep (P < 0.01 vs. cattle) and in goats (P < 0.05 vs. sheep; P < 0.01 vs. cattle) than in cattle. The significant differences in P4503A expression observed in LIM and PDM cattle are consistent with previously published data on strain-and breed-differences pointed out in rats and men. As far as a possible sex-effect is concerned, no clear-cut evidence is likely to be drawn. Finally, P4503A expression was more relevant in small ruminants. ruminants / liver drug metabolism / CYP3A / gender / breed

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Section: Discussionmentioning

confidence: 98%

“…In cattle and other domestic animals, possible gendereffects on pharmacokinetics, including P450 drug metabolism, have already been described [4,6,8,9,17,18,36,40,52].…”

Section: Discussionmentioning

confidence: 99%

Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants

et al. 2005

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“…Table I Pharmacokinetic parameters of antipyrine in saliva after intravenous and per os administration (10 day-old calves) (n = 10, x ± SD) to.5 -half-life; k -elimination coefficient; CIA -metabolic clearance; AVC -area under curve; F -bioavailability Except for man, only few comparative data are available on the pharmacokinetics of antipyrine after intravenous and oral administration. In general, it is difficult to determine whether pharmacokinetics data obtained in calves can be extrapolated directly to man and laboratory animals (Depelchin et al 1988;Jan us et al 1991).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Simplified Antipyrine Test in Calves

Janus¹,

Suszycka²,

Muszczynski³

1997

Acta Vet. Brno

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The purpose of this study was to test a modification of antipyrine test in calves. The experiment was carried out on 10 calves (bulls of black and white breed). Each subject received on days 10 and 20 of life. respectively. 15 mg.kg· l body mass of antipyrine as an intravenous bolus injection. followed by its oral administration "in substantia" in gelatin capsules 48 hours later. The concentrations of antipyrine in their saliva were repeatedly determined. Pharmacokinetics of antipyrine was followed in each subject (according to a one-compartment open model) using five modifications: a complete study (A). and four abbreviated studies. i.e using the 4. 8 and 12 h saliva collection times (B). the 4 and 8 h collection times (C), further the 4 and 12 h (D). and finally the 8 and 12 h saliva collection times (E). Correlational analysis was used to compare the substance kinetics from the complete set of data obtained from all saliva collections with the results using each of the abbreviated approaches.Based on the complete kinetics studies, mean variables for antipyrine were as follows: half-life In conclusion. we demonstrated that antipyrine pharmacokinetic parameters in calves can be determined with reasonable precision using a two-point or three-point saliva sampling procedure following a single oral dose. Moreover. this simplified sampling method can be used for largescale investigations. where estimation of hepatic mixed function oxygenases (MFO) activity is needed.Antipyrine, intravenous and oral administration. MFO system, calves

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“…Paper 203 Disc observation is in general agreement with studies performed in humans and laboratory animals (Kearns & Read, 1989;Morselli, 1989;Crom et al, 1991;Siegmund et al, 1991). Depelchin et al (1988) obtained different results. They recorded no significant changes in apparent volume of distribution of antipyrine in calves from birth to 6 months of age.…”

Section: R Es Ul Tsmentioning

confidence: 99%

“…Effect of sex on antipyrine metabolism in cattle was studied by Depelchin et al (1988), but only in calves up to the age of 6 months (metabolites of antipyrine were not determined) and by Witkamp et al (1991), but only in adult animals.…”

mentioning

confidence: 99%

The effect of sex on antipyrine metabolism in cattle at different ages

Janus

Antoszek

1999

Vet Pharm & Therapeutics

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The aim of this study was to determine the effect of sex on the metabolism of antipyrine by measuring the antipyrine plasma clearance as well as excretion of three major metabolites in urine in cattle of different ages. The experiment was carried out on 10 female and 10 male cattle of Black and White breed. The antipyrine test was carried out at 1, 2, 4, 6, 8, 12 and 18 months of age for each animal (single dose of 10 mg/kg antipyrine were given intravenously). The concentrations of antipyrine, 4-hydroxyantipyrine (4-OHA), 3-hydroxymethylantipyrine (HMA) and norantipyrine (NORA) were measured in plasma and urine by high performance liquid chromatography (HPLC). The apparent volume of distribution of antipyrine (aVd) decreased significantly between 1 and 18 months of age, but mean aVd values observed in males and females were not statistically different. The experimental period was characterised by a steady decrease (statistically significant) in antipyrine half-life (t1/2beta). These values did not differ significantly between males and females under 12 months. In 12 and 18 month-old animals the antipyrine half-life in the females was significantly shorter than in the males. The systemic clearance (Cls) of antipyrine increased significantly between 1 and 18 months of age. No significant differences were observed between systemic clearance of antipyrine in males and females under 12 months. In 12 and 18 month-old animals the Cls values were significantly higher in females than in males. Following intravenous administration, recovery of antipyrine and its three main metabolites increased significantly with age. These values did not differ significantly between males and females under 12 month of age. In 12 and 18 month-old females the excretion of 4-OHA and HMA in urine was significantly higher than in males at the same age. The excretion of NORA and unchanged antipyrine in males and females did not differ significantly. The partial clearances of antipyrine metabolites (Cl(m)) increased significantly between 1 and 18 months of age. No significant differences were observed between Cl(m) values in males and females under 12 months of age. In 12 and 18 month-old females the partial clearances of 4-OHA and HMA were significantly higher than in males. The clearance of NORA was significantly higher in 18 month-old females than in males. In conclusion, we report a sex-linked difference in plasma antipyrine clearance and urinary excretion of the main metabolites of antipyrine in cattle over 12 months of age, the females being the more active metabolizers.

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Effects of age, sex and breed on antipyrine disposition in calves

Cited by 23 publications

References 16 publications

Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants

Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants

Evaluation of Simplified Antipyrine Test in Calves

The effect of sex on antipyrine metabolism in cattle at different ages

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