Effects of Age, Strain, and Dietary Carbohydrate on the Hepatic Metabolism of Male Rats

Abstract

The effects of age and the duration of feeding either a 65% sucrose or a 65% starch diet to normolipemic Wistar and potentially hyperlipemic-hyperglycemic BHE male rats on hepatic metabolite levels, calculated redox and phosphorylation states were studied. Consistent with previous reports, the feeding of sucrose to BHE rats hastened the appearance of hyperlipemia while having little effect in Wistar rats. The changes in hepatic metabolites were consistent with an increased hepatic lipogenesis in BHE rats. The results suggest that the effects of feeding sucrose to BHE rats potentiate the genetically increased hepatic lipogenesis in these rats.

The effect of high-amylose cornstarch on lipid metabolism in OVX rats is affected by fructose feeding

“…Sucrose has been shown to increase both plasma cholesterol and TAG concentrations in guinea pigs [27], but a study in rats has demonstrated that substituting sucrose with starch results in a decrease in plasma cholesterol and TAG concentrations [28]. In addition, greater cholesterogenesis in hepatocytes has been observed in rats fed sucrose compared with those fed starch [29].…”

Rat Strain Differences in Gluconeogenesis by Isolated Hepatocytes

“…Age augments these strain differences (4). As BHE rats age, lipemia, glycemia, and a variety of tissue degenerative changes develop (5)(6)(7). One aspect of metabolism heretofore uninvestigated in these two strains is the synthesis of glucose via the gluconeogenic pathway.…”

Effect of Carbohydrate Diet Type upon Obesity and Hyperlipemia in the Zucker fa/fa Rat

“…Triglyceridemia of the fa/fa rats pair-fed on the (S) or (A) diets inversely evolved to that described for ad libitum feeding [3][4][5]17], These authors report a hypertriglyceridemic effect for the sucrose diet compared to starch diet. Changes in our triglyceridemia results can be related to insulinemias.…”

“…A diet rich in sucrose, as opposed to starch, leads to increased levels of the follow ing parameters in normal subjects and in Wistar and Sprague-Dawley rats: hepatic lip ids [1,2], circulating triacylglycerols [2][3][4][5][6], and insulinemia [5,[7][8][9][10][11] without causing obesity. Glycemia is either changed [5,12,13] or normal [2] after an oral or a venous glucose overload.…”