Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

Colotti, Chiara; Cavallini, Gabriella; Vitale, Rosa; Donati, Alessio; Maltinti, Maristella; Ry, Silvia Del; Bergamini, Ettore; Giannessi, Daniela

doi:10.1007/s10522-005-4906-z

Cited by 45 publications

(32 citation statements)

References 34 publications

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“…Indeed, Pietrangelo et al [59] have clearly shown an increased percentage of fast, white muscle fibres in CFS patients. In addition to these findings in different muscle types, several human studies have demonstrated an attenuated HSP response to stress in elderly individuals in relation to enhanced oxidative stress [60,61]. It is tempting to speculate that the accumulation of two or more stressors might be the cause of a lowering of spontaneous and induced HSP production.…”

Section: Heat Shock Proteins In Cfs Patientsmentioning

confidence: 89%

Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins

Jammes¹,

Steinberg²,

Delliaux³

2012

Journal of Internal Medicine

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Abstract. Jammes Y, Steinberg JG, Delliaux S (AixMarseille University, Marseille, France). Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant ⁄ antioxidant status and heat shock proteins. J Intern Med 2012; 272: 74-84.Objectives. A history of high-level physical activity and ⁄ or acute infection might constitute stress factors affecting the plasma oxidant-antioxidant status and levels of heat shock proteins (HSPs) in patients with chronic fatigue syndrome (CFS).Design. This case-control study compared data from 43 CFS patients to results from a matched control group of 23 healthy sedentary subjects.Setting and subjects. Five patients had no relevant previous history (group I). Eighteen had practised high-level sport (group II), and severe acute infection had been diagnosed in nine patients (group III). A combination of sport practice and infection was noted in 11 patients (group IV).Interventions. After examination at rest, all subjects performed a maximal cycling exercise test. Plasma levels of two markers of oxidative stress [thiobarbituric acid reactive substances (TBARS) and reduced ascorbic acid (RAA)] and both HSP27 and HSP70 were measured.Results. At rest, compared with the control group, the TBARS level was higher in groups II, III and IV patients, and the RAA level was lower in groups III and IV. In addition, HSP70 levels were significantly lower in all CFS groups, compared with controls, but negative correlations were found between resting HSP27 and HSP70 levels and the history of physical activity. After exercise, the peak level of TBARS significantly increased in groups II, III and IV, and the variations in HSP27 and HSP70 were attenuated or suppressed, with the greatest effects in groups III and IV.Conclusion. The presence of stress factors in the history of CFS patients is associated with severe oxidative stress and the suppression of protective HSP27 and HSP70 responses to exercise.

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Section: Heat Shock Proteins In Cfs Patientsmentioning

confidence: 89%

Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins

Jammes¹,

Steinberg²,

Delliaux³

2012

Journal of Internal Medicine

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“…A number of recent microarray studies have found that metabolic genes are disproportionately influenced by environmental stress, senescence, and inbreeding treatments (Girardot et al 2004;Landis et al 2004;Wang et al 2004;Englander 2005;Kristensen et al 2005). At a broad level, the role of metabolism in these processes may account for interactions between environmental stress and the magnitude of inbreeding depression (Crnokrak and Roff 1999;Keller and Waller 2002;Armbruster and Reed 2005), quantitative genetic correlations between stress resistance and extended life span Rose et al 1992;Force et al 1995;Zwaan et al 1995;Chippindale et al 1998;Norry and Loeschcke 2003), and similarities among the molecular effects of stress, inbreeding, and aging treatments observed in several species (Chen et al 2002;Brunet et al 2004;Lamming et al 2004;Colotti et al 2005;Kristensen et al 2005).…”

Section: Discussionmentioning

confidence: 99%

The Association Among Gene Expression Responses to Nine Abiotic Stress Treatments in Arabidopsis thaliana

Swindell

2006

Genetics

114

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The identification and analysis of genes exhibiting large expression responses to several different types of stress may provide insights into the functional basis of multiple stress tolerance in plant species. This study considered whole-genome transcriptional profiles from Arabidopsis thaliana root and shoot organs under nine abiotic stress conditions (cold, osmotic stress, salt, drought, genotoxic stress, ultraviolet light, oxidative stress, wounding, and high temperature) and at six different time points of stress exposure (0.5, 1, 3, 6, 12, and 24 hr). In roots, genomewide correlations between transcriptional responses to different stress treatments peaked following 1 hr of stress exposure, while in shoots, correlations tended to increase following 6 hr of stress exposure. The generality of stress responses at the transcriptional level was therefore time and organ dependent. A total of 67 genes were identified as exhibiting a statistically significant pattern of gene expression characterized by large transcriptional responses to all nine stress treatments. Most genes were identified from early to middle (1-6 hr) time points of stress exposure. Analysis of this gene set indicated that cell rescue/defense/virulence, energy, and metabolism functional classes were overrepresented, providing novel insight into the functional basis of multiple stress tolerance in Arabidopsis.T HE genetic effects of environmental stress have been extensively studied from the standpoint of cellular physiology (Singh et al. 2002;Mahalingam et al.

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“…With aging, the HSP response to stress is blunted while the propensity to develop diabetes increases. 50 Hypertension is associated with insulin resistance and impaired insulin signaling. 51 Angiotensin II increases inflammatory cytokines, particularly NF-B, which can impair insulin signaling.…”

Section: Agents or Conditions That Alter Hsps And Diabetesmentioning

confidence: 99%

Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis

Hooper

2007

Metabolic Syndrome and Related Disorders

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Metabolic syndrome and type 2 diabetes are progressive, indolent, multi-organ diseases. Understanding the abnormalities of heat shock proteins (HSPs) in these diseases is paramount to understanding their pathogenesis. In insulin resistant states and diabetes, heat shock factor 1(HSF-1) is low in insulin sensitive tissues, resulting in low Hsp 60, 70, and 90 levels. We propose that low Hsps levels are the result of decreased insulin action leading to less phos-phorylation of PI3K, PKB, and glycogen synthase kinase-3 (GSK-3). Importantly, less GSK-3 phosphorylation (and thus more GSK-3 activity) will lower HSF-1. Low Hsps make organs vulnerable to injury, impair the stress response, accelerate systemic inflammation, raise islet amyloid polypeptide, and increase insulin resistance. Feeding this cycle is excess saturated fat and calorie consumption, hypertension, inactivity, aging, and genetic predisposition-all of which are a associated with high GSK-3 activity and low Hsps. Support for the proposed "vicious" cycle is based on the observation that GSK-3 inhibition and Hsp stimulation result in increased insulin sensitivity, reduced accumulation of degenerative proteins with in the cell, improved wound healing, decreased organ damage and improved recovery from vas-cular ischemia. Recognizing GSK-3 and Hsps in the pathogenesis of insulin resistance, the central common feature of the metabolic syndrome, and type 2 diabetes will expand our understanding of the disease, offering new therapeutic options. What are HSPs? T he unabated global increase in the prevalence of metabolic syndrome and type 2 diabetes mellitus adds urgency and challenge to researchers and health care providers. New insights are needed in order to treat these progressive , indolent, multi-organ diseases. In this review we propose a previously undescribed progressive cycle that promotes insulin resistance , inflammation, and cell-organ-host vulnerability. Novel elements of the cycle are HSPs, HSF-1, and GSK-3. Heat shock proteins (HSPs) are proteins that

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Effects of Aging and Anti-Aging Caloric Restrictions on Carbonyl and Heat Shock Protein Levels and Expression

Cited by 45 publications

References 34 publications

Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins

Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins

The Association Among Gene Expression Responses to Nine Abiotic Stress Treatments in Arabidopsis thaliana

Insulin Signaling, GSK-3, Heat Shock Proteins and the Natural History of Type 2 Diabetes Mellitus: A Hypothesis

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