Effects of albumin and synthetic polypeptide-coated oxygenators on IL-1, IL-2, IL-6, and IL-10 in open heart surgery

Simsek, Erdal; Karapınar, Kasım; Bugra, Onursal; Ulus, A. Tulga; Sarıgül, Ali

doi:10.1016/j.asjsur.2013.09.004

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…Overexpression of IL-10 can markedly reduce the inflammatory reaction from skin damage (Peranteau et al, 2008) and can downregulate IL-6 and other pro-inflammatory factor levels (Sun et al, 2010). Some studies have showed that plasma IL-10 levels increase after major surgery (Weis et al, 2009;Simsek et al, 2013). These studies also showed that IL-6 and IL-10 are critical in tissue damage and wound healing, respectively.…”

Section: Discussionmentioning

confidence: 78%

Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. This study aimed to discuss the effects of 3 different analgesia methods on serum IL-6 and IL-10 in patients after cesarean delivery. Thirty full-term women, who underwent cesarean delivery, were randomly assigned to 3 analgesia groups (10 cases each) as follows: intramuscular injection of 100 mg pethidine (NC group), patient controlled epidural analgesia (PCEA) of 5 mg morphine plus 150 mg ropivacaine (MR group), and patient controlled intravenous analgesia (PCIA) of 150 mg sufentanil plus 5 mg droperidol (SF group). An electronic analgesia pump was available in all 3 groups. At 4, 12, 24, and 48 h after surgery, visual analogue scale (VAS) pain scores were evaluated, IL-6 and IL-10 serum levels were measured, and adverse reactions were documented. The MR and SF groups responded well to analgesia. VAS scores at 12 and 24 h in these 2 groups were significantly lower than those in the NC group (P < 0.05). IL-6 and IL-10 levels were elevated to varying degrees postoperatively in all 3 groups. In the MR and SF groups, no significant difference occurred at each time point (P > 0.05), but compared with the NC group, significant differences were observed at 12 and 24 h (P < 0.05). Both PCIA and PCEA produced good analgesic effect, decreased postoperative level of serum IL-6, 4779Effects of analgesia methods on serum ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4778-4783 (2015) promoted release of anti-inflammatory factor IL-10, maintained balance in postoperative serum IL-6 level, and reduced the postoperative inflammatory response. Adverse reactions were significantly higher with epidural morphine than with intravenous sufentanil.

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Section: Discussionmentioning

confidence: 78%

Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery

Zhang

et al. 2015

Genet. Mol. Res.

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“…Previous studies showed that plasma level of IL-10 increased after major surgery. [33,34,35] The emergence of IL-10 as a key anti-inflammatory cytokine produced by Th2 cells is characterized by strong anti-inflammatory activity. [36] The overexpression of IL-10 can inhibit the release of proinflammatory cytokines, such as IL-6 and TNF-alpha.…”

Section: Discussionmentioning

confidence: 99%

Does Clonidine Affect the Anti-Inflammatory Response of IL-10 in Patients Undergoing Laparoscopic Cholecystectomy?

Ansari¹,

Nigam²,

Mishra³

et al. 2019

jemds

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BACKGROUND As immune mediators, cytokines are thought to regulate many biological functions. Tissue injury affects the immune system which rapidly produces pro-inflammatory and anti-inflammatory cytokines that causes injury and spread of infection to provide an appropriate environment for tissue healing. The surgery causes stressful response which leads to changes in cytokine level. Our aim was to evaluate the effects of anti-inflammatory and hemodynamic stress response of clonidine during laparoscopic cholecystectomy. METHODS Thirty patients [American Society of Anesthesiologists (ASA) Grade I and Grade II] were selected and randomly assigned into two groups. Group A (Normal Saline Group): Patients received 20 ml of normal saline intravenous and Group B (Clonidine Group): patients received clonidine 1 µgm/Kg + normal saline (20 ml) intravenous, 15 minutes before induction. Blood concentrations of antiinflammatory cytokines IL-10, was determined preoperatively, just after extubation and 12 hours after the operation. The cytokines assay was performed with the help of commercially available ELISA kit. RESULTS The demographic data age, gender, weight, height, BMI, ASA grade and baseline hemodynamic variables were comparable between group A and group B. Clonidine (1 µgm/kg) as a premedication for general anaesthesia had significantly better hemodynamic control as compared to normal saline group. IL-10 level was increased at extubation and at 12 hours postoperatively in both groups, but level was comparatively more in clonidine group as compared to normal saline group (at extubation (53.73±12.85 vs. 47.96±14.99) and at 12 hrs. postoperatively (110.43±13.58 vs. 96.64±44.76). Therefore, anti-inflammatory response IL-10 was higher in clonidine group as compared to the normal saline group. CONCLUSIONS Intravenous clonidine as a pre-medication could be recommended to maintain hemodynamic stability with minimal side effects during laparoscopic surgeries in ASA I/II patients. The anti-inflammatory response was greater in clonidine group as compared to saline group but not significantly different.

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“…Albumin and fibrinogen have been reported to be the predominant proteins to be adsorbed on vascular graft surfaces [10]. In particular, fibrinogen adsorption has been correlated with promoting 2 of 25 platelet and monocyte/macrophage adhesion, thereby leading to blood clotting [11], while albumin-coated surfaces seems to reduce leukocyte interaction, mitigating the inflammatory response [10,12].…”

Section: Introductionmentioning

confidence: 99%

Computational Characterization of Mechanical, Hemodynamic, and Surface Interaction Conditions: Role of Protein Adsorption on the Regenerative Response of TEVGs

Riveros

Garcia-Brand

Rodriguez-Soto

et al. 2022

IJMS

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Currently available small diameter vascular grafts (<6 mm) present several long-term limitations, which has prevented their full clinical implementation. Computational modeling and simulation emerge as tools to study and optimize the rational design of small diameter tissue engineered vascular grafts (TEVG). This study aims to model the correlation between mechanical-hemodynamic-biochemical variables on protein adsorption over TEVG and their regenerative potential. To understand mechanical-hemodynamic variables, two-way Fluid-Structure Interaction (FSI) computational models of novel TEVGs were developed in ANSYS Fluent 2019R3® and ANSYS Transient Structural® software. Experimental pulsatile pressure was included as an UDF into the models. TEVG mechanical properties were obtained from tensile strength tests, under the ISO7198:2016, for novel TEVGs. Subsequently, a kinetic model, linked to previously obtained velocity profiles, of the protein-surface interaction between albumin and fibrinogen, and the intima layer of the TEVGs, was implemented in COMSOL Multiphysics 5.3®. TEVG wall properties appear critical to understand flow and protein adsorption under hemodynamic stimuli. In addition, the kinetic model under flow conditions revealed that size and concentration are the main parameters to trigger protein adsorption on TEVGs. The computational models provide a robust platform to study multiparametrically the performance of TEVGs in terms of protein adsorption and their regenerative potential.

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Effects of albumin and synthetic polypeptide-coated oxygenators on IL-1, IL-2, IL-6, and IL-10 in open heart surgery

Abstract: Synthetic polypeptide-coated advanced technology, which employed oxygenators, had an important attenuator effect on acute phase reactants and also on the inflammatory response.

Cited by 8 publications

References 24 publications

Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery

Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery

Does Clonidine Affect the Anti-Inflammatory Response of IL-10 in Patients Undergoing Laparoscopic Cholecystectomy?

Computational Characterization of Mechanical, Hemodynamic, and Surface Interaction Conditions: Role of Protein Adsorption on the Regenerative Response of TEVGs

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