Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery

Abstract

ABSTRACT. This study aimed to discuss the effects of 3 different analgesia methods on serum IL-6 and IL-10 in patients after cesarean delivery. Thirty full-term women, who underwent cesarean delivery, were randomly assigned to 3 analgesia groups (10 cases each) as follows: intramuscular injection of 100 mg pethidine (NC group), patient controlled epidural analgesia (PCEA) of 5 mg morphine plus 150 mg ropivacaine (MR group), and patient controlled intravenous analgesia (PCIA) of 150 mg sufentanil plus 5 mg droperidol (SF group). An electronic analgesia pump was available in all 3 groups. At 4, 12, 24, and 48 h after surgery, visual analogue scale (VAS) pain scores were evaluated, IL-6 and IL-10 serum levels were measured, and adverse reactions were documented. The MR and SF groups responded well to analgesia. VAS scores at 12 and 24 h in these 2 groups were significantly lower than those in the NC group (P < 0.05). IL-6 and IL-10 levels were elevated to varying degrees postoperatively in all 3 groups. In the MR and SF groups, no significant difference occurred at each time point (P > 0.05), but compared with the NC group, significant differences were observed at 12 and 24 h (P < 0.05). Both PCIA and PCEA produced good analgesic effect, decreased postoperative level of serum IL-6, 4779Effects of analgesia methods on serum ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 4778-4783 (2015) promoted release of anti-inflammatory factor IL-10, maintained balance in postoperative serum IL-6 level, and reduced the postoperative inflammatory response. Adverse reactions were significantly higher with epidural morphine than with intravenous sufentanil.

TNF-α and sTNF-RII Are Associated with Pain Following Hip Fracture Surgery in Older Adults

“…In addition, because the effect of peri-operative changes in inflammatory mediators on postoperative pain after hip fracture is unknown, additional time points of blood sampling (e.g., POD0, POD1, POD2) need to be incorporated in future study design to allow an expanded assessment in the influence of trajectory of these mediators on progression of postoperative pain. Although there is evidence suggesting that anesthesia type could affect levels of inflammatory mediators [50,51], this did not appear to be the case in our study. Despite our observation, anesthesia type and modality should be considered in the analysis of future postoperative pain biomarker investigations.…”

Postoperative Analgesic Effects of Different Doses of Epidural Hydromorphone Coadministered with Ropivacaine after Cesarean Section: A Randomized Controlled Trial

“…Before the patient was transferred to the postanesthesia care unit, the epidural catheter was removed and the patient-controlled intravenous analgesia (PCIA) was administered immediately using an electronic analgesia pump occupied with sulfentanil according to the following protocol: 0 μ g/h continuous dose, 2 μ g/h self-controlled dose, 10 min lock time, and 12 μ g/h controlled maximum dose. The dosage of sulfentanil is similar to previous studies [13]. All other NSAIDs, cycloxygenase-2 inhibitors, and opioids were prohibited during the postoperative period.…”

Effects of different epidural initiation volumes on postoperative analgesia in cesarean section

“…Several methods, including wound infiltration with a local anesthetic and magnesium sulphate, wound infiltration with tramadol and levobupivacaine, a magnesium sulphate infusion for preemptive analgesia, a transverse abdominal plane block (TAPB) performed by adding dexamethasone to levobupivacaine, infiltration by placing a continuous catheter for a TAPB or the wound area, the administration of intrathecal and intravenous betamethasone, and the addition of dexmedetomidine to increase the efficacy of epidural anesthesia and analgesia have all been used to treat pain after a cesarean section [17][18][19][20][21][22][23]. We administered epidural analgesia to our patients in order to avoid the side effects of systemically administered opioids, such as nausea and vomiting, urinary retention, pruritus, and respiratory depression, and to reduce the postoperative antiinflammatory response [24][25]. CSE anesthesia was preferred in our study because it combines the advantages of spinal anesthesia (rapid onset, minimal toxic effects, high efficacy) and epidural anesthesia (lengthening the duration of anesthesia), partially reduces their disadvantages, and allows for postoperative analgesia [15,[25][26][27][28].…”