Effects of alendronate on the peri‐implant bone in rats

Oh, Kyung Chul; Moon, Hi-Soo; Lee, Jae Hoon; Yb, Park; Kim, Jeehwan

doi:10.1111/odi.12258

Cited by 14 publications

(10 citation statements)

References 54 publications

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“…Thus, anti-resorptive medications, such as sodium alendronate, have been effective in this treatment 1 , 4 , 7 , 14 , 20 . Apparently, according to previous studies 7 , 11 , 12 , 19 , 28 , sodium alendronate is also able to improve bone repair at the bone/implant interface under osteoporosis conditions, at least at the beginning of the bone tissue evaluation.…”

Section: Discussionmentioning

confidence: 86%

“…The role of estrogen in bone integrity maintenance has been recognized for a while, although estrogen therapy shows several non-skeletal, adverse effects, including vascular events and breast carcinoma 5 . Some drugs act by decreasing bone resorption and therefore delaying bone loss rate (antiresorptive therapy), such as bisphosphonates, calcitonin and the human monoclonal antibody, denosumab, or by promoting bone formation (anabolic therapy), such as teriparatide 1 , 3 , 14 , 18 , 19 , 28 .…”

Section: Introductionmentioning

confidence: 99%

“…Several studies investigated the effects of the oral bisphosphonates in osteoporosis conditions related to the risk of fractures 1 , 4 , 6 , 14 , bone mineral density 3 , 6 , 9 , 20 , 28 , bone strength 3 , 28 and bone repair 2 , 7 , 11 , 19 . These studies still remain without some information regarding the molecular and microstructural features around implants in osteoporotic situations.…”

Section: Introductionmentioning

confidence: 99%

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Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals

et al. 2017

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Sodium alendronate is a bisphosphonate drug that exerts antiresorptive action and is used to treat osteoporosis. Objective The aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin).Material and Methods A total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate). A surface treated implant was installed in both tibial metaphyses of each rat. Euthanasia of the animals was conducted at 14 (immunhostochemistry) and 42 days (immunohistochemistry, micro CT and PCR). Data were subjected to statistical analysis with a 5% significance level.Results Bone volume (BV) and total pore volume were higher for ALE group (P<0.05). Molecular data for RUNX2 and BSP proteins were significantly expressed in the ALE group (P<0.05), in comparison with the other groups. ALP expression was higher in the CTL group (P<0.05). The immunostaining for RUNX2 and osteopontin was positive in the osteoblastic lineage cells of neoformed bone for the CTL and ALE groups in both periods (14 and 42 days). Alkaline phosphatase presented a lower staining area in the OST group compared to the CTL in both periods and the ALE at 42 days.Conclusion There was a decrease of osteocalcin precipitation at 42 days for the ALE and OST groups. Therefore, treatment with short-term sodium alendronate improved bone repair around the implants installed in the tibia of osteoporotic rats.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals

et al. 2017

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“…On comparison between both groups, significant difference (<0.05) in the radiographic bone levels on mesial and distal aspect of implants were observed only at 3 and 9 months, respectively, which represents the effectiveness of sodium alendronate in enhancing the bone formation. These results were in accordance with the results by Veena and Prasad,[ 10 ] Oh et al .,[ 11 ] and Zuffeti et al . [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

Comparative clinicoradiographical evaluation of effect of aminobisphosphonate (sodium alendronate) on peri-implant bone status: Controlled clinical trial

Aggarwal

Babaji²,

Nathan

et al. 2016

J Int Soc Prevent Communit Dent

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Aim:The present study aims to compare the peri-implant bone status around immediately loaded dental implants treated with aminobisphosphonate solution and untreated control implants in terms of clinical and radiographical parameters.Materials and Methods:A total of 24 patients were randomly divided equally into two groups. This study was conducted in accordance to the Helsinki's declaration of 1975, revised in 2000, and with the approval of the institutional ethical committee. In the control group after preparation, osteotomy sites were irrigated with normal saline solution, whereas in the test group osteotomy sites were irrigated with modified bisphosphonate solution and then TRX-OP, Hi-Tec dental implants were inserted. Clinical parameters, such as modified plaque and gingival index, probing depth, mobility, and radiographic parameters were recorded at baseline (0), 3, 6, and 9 months. Data analysis was performed using the Statistical Package for the Social Sciences version 17 for windows, and the statistical techniques employed were repeated measures analysis of variance, independent sample t-test, and paired sample t-test.Results:Reduction in mean radiographic bone levels (height) was observed on the mesial and distal aspect of the control group in comparison to its baseline at all intervals. In the test group, there was reduction in mean radiographic bone levels on mesial and distal aspect of the implant site in comparison to its baseline till 6-month follow up, however, at 9 month, there was gain in bone level on both mesial and distal aspect of implant. This represents the effectiveness of sodium alendronate in enhancing the bone formation. On comparison, between both groups on mesial and distal aspect of implants, statistically significant differences were observed at 3 and 9 months on mesial and distal aspect, respectively, without any clinical evidence of mobility in the test group.Conclusion:Implant site treated with aminobisphosphonate solution represents greater efficacy in enhancing bone formation when used as an irrigant; thus, it is considered beneficial in implant dentistry.

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“…An experimental study in mice was performed to determine whether alendronate (100 mg/ml, 0.5 ml/kg) can affect the bone to the peri-implant area and may be a risk factor for the survival and success of the implant in rat maxillae. After computed tomography, histological JRPMS examination and biochemical analysis, the results showed non-statistically significant results in the first two analyses, while biochemical analysis showed a significant difference in the serum osteocalcin concentration, an indicator that could be used in the future for this purpose 17 .…”

Section: Animal Studiesmentioning

confidence: 93%

The role of bisphosphonates in success and survival of dental implants - effects in osseointegration

Tsikouris¹

2020

JRPMS

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The purpose of this study was to research published studies concerning the effect of bisphosphonates in the success and survival of dental implants. An electronic PubMed search was conducted and we have included clinical trials as well as reviews which include human and animal studies. The most common complication in the published literature for bisphosphonates and dental implants was found to be osteonecrosis of the jaw. As a result, we focused in non-osteonecrosis studies. The results of our review are mixed and there is lack of consensus concerning potential beneficial or detrimental effects of bisphosphonates and osseo-integration of dental implants.

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Effects of alendronate on the peri‐implant bone in rats

Abstract: Three approaches were utilized in evaluating the effects of alendronate. It appears serum osteocalcin levels may serve as an adjuvant marker for this purpose, although further studies are required to confirm this.

Cited by 14 publications

References 54 publications

Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals

Short term sodium alendronate administration improves the peri-implant bone quality in osteoporotic animals

Comparative clinicoradiographical evaluation of effect of aminobisphosphonate (sodium alendronate) on peri-implant bone status: Controlled clinical trial

The role of bisphosphonates in success and survival of dental implants - effects in osseointegration

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