Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice

Łuszczki, Jarogniew J.; Włodarczyk, Maciej; Gleńsk, Michał; Marzęda, Ewa; Durmowicz, Dariusz; Florek-Łuszczki, Magdalena

doi:10.26444/jpccr/71433

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…Due to structural similarity between four substances, this data suggests a possible low toxicity and safety at the chosen dose for all stereoisomers. Research shows that the use of high doses are not necessarily related to high toxicity, as other studies that also have reports of substances with low toxicity, high doses with pharmacological activity and similarity to the isomers [52,53,54,55,56,57].…”

Section: Resultsmentioning

confidence: 91%

Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers

et al. 2015

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Stereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (´)-cis-EC, (+)-trans-EC, and (´)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced anticonvulsant test, all of the stereoisomers (at 300 mg/kg) increased the latency to seizure onset, and afforded 100% protection against the death of the animals. In the maximal electroshock-induced seizures (MES) test, prevention of tonic seizures was also verified for all of the isomers tested. However, the isomeric forms (+) and (´)-trans-EC showed 25% and 12.5% inhibition of convulsions, respectively. In the pilocarpine-induced seizures test, all stereoisomers demonstrated an anticonvulsant profile, yet the stereoisomers (+) and (´)-trans-EC (at 300 mg/kg) showed a more pronounced effect. A strychnine-induced anticonvulsant test was performed, and none of the stereoisomers significantly increased the latency to onset of convulsions; the stereoisomers probably do not act in this pathway. However, the stereoisomers (+)-cis-EC and (+)-trans-EC greatly increased the latency to death of the animals, thus presenting some protection. The four EC stereoisomers show promise for anticonvulsant activity, an effect emphasized in the isomers (+)-cis-EC, (+)-trans-EC, and (´)-trans-EC for certain parameters of the tested methodologies. These results serve as support for further research and development of antiepileptic drugs from monoterpenes.

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Section: Resultsmentioning

confidence: 91%

Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers

et al. 2015

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“…More specifically, it was found that borneol, thymoquinone [12], xanthotoxin [9], imperatorin and osthole [7,8,11], produced a definite (clear-cut) anticonvulsant action in the mouse MES model. In contrast, several naturally occurring substances, including alizarin, arbutin, betulin, curcumin, diosmin, esculetin, ellagic acid, gallic acid, hesperidine, linalool, menthofuran, piperitol, piperonal, quercetin, alpha-terpineol, theobromine, beta-thujaplicin, ursolic acid and vanillin, produced no or negligible anticonvulsant activity in mice challenged with the screening procedure in the mouse MES model [12,24].…”

Section: Discussionmentioning

confidence: 93%

“…before the electroconvulsions resulted in no anticonvulsant effect in the mouse MES model. It is worth mentioning that in the presented study the pretreatment times and doses of tested compounds were identical to those described previously in the screening test allowing selection of compounds with anticonvulsant activity [9,11,12,24]. Subsequently, the ED 50 values of both compounds in the MES test were determined -322 (281-369) mg/kg for alantolactone and 336 (285-396) mg/kg for isoalantolactone.…”

Section: Discussionmentioning

confidence: 95%

Alantolactone and isoalantolactone suppress maximal electroshock-induced tonic seizures in mice

Łuszczki¹,

Marzęda²,

Kondrat-Wróbel³

et al. 2014

J Pre Clin Clin Res.

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Introduction and objective. The aim of this study was to perform the anticonvulsant screening test to determine whether two sesquiterpene lactones (alantolactone and isoalantolactone) isolated from herbs and medicinal plants offer a distinct protection against maximal electroshock (MES)-induced tonic seizures in mice. Materials and methods. The screening test was performed for alantolactone and isoalantolactone administered intraperitoneally in a constant dose of 300 mg/kg at 4 various pretreatment times (i.e., 15, 30, 60 and 120 min.) before the MES test. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via ear-clip electrodes. Subsequently, the median effective doses (ED 50 values) for alantolactone and isoalantolactone were determined in the MES test in mice. Results. In the screening test, both compounds produced a 37.5% protection against MES-induced tonic seizures in mice, when administered i.p. at 15 min. prior to the MES test. In contrast, alantolactone and isoalantolactone administered i.p. at 30, 60 and 120 min. prior to the test produced no anticonvulsant activity in mice subjected to the MES test. The experimentallyderived ED 50 values for alantolactone and isoalantolactone, administered intraperitoneally at 15 min. before the MES test, were 322 (281-369) mg/kg and 336 (285-396) mg/kg, respectively. Conclusions. Alantolactone and isoalantolactone (2 sesquiterpene lactones) are worth considering as potentially favourable compounds in epileptology, if the results from this study could be extrapolated into clinical settings.

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“…When curcumin was given intraperitoneally to adult male Swiss mice at a dose of 300 mg/kg at four different pre-treatment times of 15,30, 60 or 120 minutes, a study found that curcumin had no anti-convulsive effect regardless of pre-treatment time in the MES model as defined by the occurrence of tonic hind limb extension [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Mechanism of Curcuma longa and Its Neuroactive Components for the Management of Epileptic Seizures: A Systematic Review

Choo

Shaikh

2021

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: Curcuma longa (Turmeric) is a tropical herbaceous perennial plant of the family Zingiberaceae and contains curcuminoids, sesquiterpenoids and monoterpenoids as its major components. Given the broad range of activities that Curcuma Longa possesses and also its use as a traditional epilepsy remedy, this review attempts to systematically review the experimentally proven activities of Curcuma longa and its bioactive components, which are related to the management of epileptic seizures. Using the PRISMA model, five databases (Google Scholar, PubMed, ScienceDirect, SCOPUS and SpringerLink) were searched using the keywords [“Curcuma longa” AND “Epilepsy”] and [“Curcuma longa” AND “Seizures”], leaving with 34 articles that met the inclusion criteria. The present systematic review elaborated on the experimentally proven potential of Curcuma longa components, such as an aqueous extract of Curcuma longa itself, Curcuma longa oil and active constituents like curcuminoids and bisabolene sesquiterpenoids found in Curcuma longa with anti-seizure potential. Using human equivalent dose calculations, human treatment parameters were suggested for each component by analysing various studies in this review. This review also determined that the principal components possibly exert their anti-seizure effect via the reduction of corticosterone, modulation of neurotransmitters signalling, modulation of sodium ion channels, reduction of oxidative DNA damage, reduction of lipid peroxidation, upgregulation of brain-derived neurotrophic factor (BDNF) and γ-aminobutyric acid (GABA) mediated inhibition. It is anticipated that this review will help pave the way for future research into the development of Curcuma longa and its neuroactive constituents as potential drug candidates for the management of epilepsy.

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Effects of alizarin, betulin, curcumin, diosmin , linalool, menthofuran, α-terpineol, theobromine, β-thujaplicin and vanillin against maximal electroshock-induced seizures in mice

Cited by 7 publications

References 21 publications

Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers

Comparative Anticonvulsant Study of Epoxycarvone Stereoisomers

Alantolactone and isoalantolactone suppress maximal electroshock-induced tonic seizures in mice

Mechanism of Curcuma longa and Its Neuroactive Components for the Management of Epileptic Seizures: A Systematic Review

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