Effects of almond intake on oxidative stress parameters: A systematic review and meta-analysis of clinical trials

Luo, Bingfeng; Mohammad, Walid Theib; Jalil, Abduladheem Turki; Saleh, Marwan Mahmood; Al-Taee, Muataz Mohammed; Alshahrani, Mohammad Y.; Mohammed, Naseer Mihdi; Hidavi, Amar

doi:10.1016/j.ctim.2023.102935

Cited by 4 publications

(1 citation statement)

References 52 publications

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“…One of the most important and dangerous consequences of CAR injection is ROS-induced damage [45]. Several studies reported the antioxidant effects of almonds, suggesting that the intake of almonds may have a beneficial role in strengthening antioxidant defenses [46][47][48]. In a study using yeast models, ASE was observed to significantly reduce the presence of ROS [27].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of a Sicilian Almond Skin Extract Using In Vitro and In Vivo Models

Arangia,

Ragno,

Cordaro

et al. 2023

IJMS

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Almond skins are known for their antioxidative and anti-inflammatory properties, which are mainly due to the presence of polyphenols. The aim of the present study was to evaluate the antioxidant and anti-inflammatory effects of almond skin extract (ASE) obtained from the Sicilian cultivar “Fascionello” and to evaluate the possible mechanisms of action using an in vitro model of human monocytic U937 cells as well as an in vivo model of carrageenan (CAR)-induced paw edema. The in vitro studies demonstrated that pretreatment with ASE inhibited the formation of ROS and apoptosis. The in vivo studies showed that ASE restored the CAR-induced tissue changes; restored the activity of endogenous antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione; and decreased neutrophil infiltration, lipid peroxidation, and the release of proinflammatory mediators. The anti-inflammatory and antioxidant effects of ASE could be associated with the inhibition of the pro-inflammatory nuclear NF-κB and the activation of the nuclear factor-erythroid 2-related factor 2 (Nrf2) antioxidant pathways. In conclusion, almond skin could reduce the levels of inflammation and oxidative stress and could be beneficial in the treatment of several disorders.

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