Effects of Aloe preparation on the histamine-induced gastric secretion in rats

Suvitayavat, Wisuda; Sumrongkit, C; Thirawarapan, Suwan; Bunyapraphatsara, Nuntavan

doi:10.1016/j.jep.2003.09.044

Cited by 26 publications

(18 citation statements)

References 19 publications

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“…vera has therapeutic properties such as antiinflammatory, wound healing, anti-diabetic, and antioxidant effects [10][11][12][13][14] . The present study however demonstrates that A. vera gel treatment (100 or 300 mg/kg BW) did not decrease the liver enzyme levels, hepatic MDA levels, or improve liver histopathology in paracetamol-induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

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Negative effects of Aloe vera gel on paracetamol-induced liver injury in rats

Samuhasaneeto¹,

Kajornvuthidej²

2014

ScienceAsia

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The effect of Aloe vera gel on paracetamol induced liver injury in rats was studied using male Wistar rats divided into four groups. Group 1 (control) received 50% sucrose orally twice daily for 2 days. Group 2 (paracetamol) received a single dose (2.5 g/kg BW) of paracetamol dissolved in 50% sucrose. Groups 3 and 4 (A. vera 100 mg and 300 mg, respectively) received a single dose (2.5 g/kg BW) of paracetamol dissolved in 50% sucrose followed by 100 or 300 mg/kg BW of A. vera gel twice daily for 2 days. Blood was collected to determine alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymatic activities. Liver tissue samples were collected for hepatic glutathione, hepatic malondialdehyde (MDA), and histopathology. The results showed that the serum levels of ALT, AST, and hepatic MDA increased significantly in the paracetamol group compared to that of the control group. The liver histopathology in the paracetamol group revealed vacuolization, cell swelling, and mild infiltration of inflammatory cells around the central vein. Necrosis was observed predominantly around the centrilobular and midzonal regions. There were no differences in hepatic glutathione levels between groups and no difference in hepatic MDA levels between the paracetamol group and A. vera gel treated groups. This study concluded that neither 100 nor 300 mg/kg BW of A. vera protected rats from the liver damage induced by a high dose of paracetamol.

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Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated that A. vera extract has therapeutic properties such as anti-inflammatory effects, wound healing, antidiabetic activities and antioxidant effects [10][11][12][13][14] . In addition, some studies show a hepatoprotective effect of A. vera.…”

Section: Introductionmentioning

confidence: 99%

Negative effects of Aloe vera gel on paracetamol-induced liver injury in rats

Samuhasaneeto¹,

Kajornvuthidej²

2014

ScienceAsia

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“…Polysaccharides (pectines and arabinogalactans) from Aloe barbedensis [32], Panax ginseng [33,34], Acmella oleracea [35,36], Bupleurum falcatum [37,38].…”

Section: Mucopolysaccharides Layer (Physical) Protectionmentioning

confidence: 99%

Centaurea cyanus L. Polysaccharides and Polyphenols Cooperation in Achieving Strong Rat Gastric Ulcer Protection

et al. 2015

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This work was aimed at testing gastroprotective effects of Centaurea cyanus L. (herba) polysaccharides (P) and polyphenols (A) fractions on stress-induced rat ulcer model. Studies evaluating acute toxicity in rats and antioxidant (chemiluminescence method) and antimicrobial (on Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739 strains) activities of Centaurea cyanus L. (herba) product, which combined polysaccharides and polyphenols fractions (PA), have also been done. Accordingly, in vivo pharmacological studies revealed high influence of PA product (500 mg kg -1 of body weight) on deep, moderate and superficial gastric mucosal lesions, greater than that of chemical reference, Ranitidine. P product was proven more effective than Ranitidine in opposing the emergence of deep necrotic lesions only, suggesting the ability of polysaccharides compounds to consolidate gastric mucous layer as well as their certain tendency for cooperation with polyphenols fractions. The acute toxicity study indicated the lack of toxicity of PA product and maximum tolerated doses greater than 1875 mg kg -1 of body weight. PA product provided augmented scavenger activity and week antimicrobial activity on Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739 strains, resulting in better opportunities for valorisation of the aerial part of Centaurea cyanus L. species in order to obtain new and effective natural medicines.

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“…vera gel has also been used as a curative agent for gastric ulcers and to protect the stomach lining (Eamlamnam et al 2006;Yusu et al 2004). These antiulcer properties of A. vera gel are probably due to several individual therapeutic effects including antiinflammatory activity, promoting cell proliferation and wound healing properties, stimulating mucus secretion and via its regulation of gastric secretions (Suvitayavat et al 2004). This particular study also showed that A. vera extracts inhibit gastric acid secretions in rats only at low concentrations.…”

Section: Gastrointestinal Activitiesmentioning

confidence: 99%

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

2015

Progress in Drug Research

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Effects of Aloe preparation on the histamine-induced gastric secretion in rats

Cited by 26 publications

References 19 publications

Negative effects of Aloe vera gel on paracetamol-induced liver injury in rats

Negative effects of Aloe vera gel on paracetamol-induced liver injury in rats

Centaurea cyanus L. Polysaccharides and Polyphenols Cooperation in Achieving Strong Rat Gastric Ulcer Protection

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

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