Effects of Alternating Lung Ventilation on Cardiopulmonary Functions in Dogs

Muneyuki, Mannosuke; Konishi, Kunihiko; Horiguchi, Ryoji; Tsujimoto, Saburo; Saito, Mitsuo; Sakakura, Sachiko; Konishi, Aiko

doi:10.1097/00000542-198304000-00009

Cited by 15 publications

(7 citation statements)

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“…These data indicate that a volume expansion of one lung during AV causes a compression and expiration of the non-inflated opposite lung. This supports our supposition that the lower intrathoracic pressure [8] during AV is due to expansion of the inflated lung partly at the expense of a volume decrease in the opposite lung.…”

Section: Cardiac Output and Central Venous Pressure Changessupporting

confidence: 90%

“…We could not find an explanation for the discrepancy between our haemodynamic results and those of Muneyuki et al [8]. During mechanical ventilation, estimations of cardiac output on the basis of thermodilution imply a wide spread of data unless three or four determinations are performed at equal intervals in the ventilatory cycles [12].…”

Section: Cardiac Output and Central Venous Pressure Changesmentioning

confidence: 68%

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Alternating versus synchronous ventilation of left and right lungs in piglets

1995

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Objective." We tested whether alternating ventilation (AV) of each lung (i. e. with a phase difference of half a ventilatory cycle) would decrease central venous pressure and so increase cardiac output when compared with simultaneous ventilation (SV) of both lungs.Theory: If, during AV, the inflated lung expands partly via compression of the opposite lung, mean lung volume will be smaller during AV than SV. As a consequence, mean intrathoracic pressure (as cited in the literature), and therefore, central venous pressure will be smaller. Design:The experiments were performed in seven anaesthetized and paralyzed piglets using a doublepiston ventilator. Minute ventilation was the same during AV and SV. Starting at SV, we alternated three times between AV and SV for periods of 10 min.Results: During AV, central venous pressure was decreased by 0.7 mmHg and cardiac output was increased by 10+4.4~ (mean, + SD) compared with SV. AV also resulted in increased arterial pressure. During one-sided inflation with closed outlet of the opposite lung, a pressure rise occurred in the opposite lung, indicating compression. Conclusion:The higher cardiac output during AV than SV can be explained by the fact that central venous pressure is lower during AV. This lower central venous pressure is very probably due to the lower mean intrathoracic pressure caused by compression of the opposite lung during unilateral inflation.

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Section: Cardiac Output and Central Venous Pressure Changessupporting

confidence: 90%

Section: Cardiac Output and Central Venous Pressure Changesmentioning

confidence: 68%

Alternating versus synchronous ventilation of left and right lungs in piglets

1995

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“…During OLV selective ventilation of one lung is applied for which specific intubation, including double‐lumen tubes, endobronchial intubation, or bronchial blockers, is necessary. Positioning is technically difficult in dogs and sheep (Muneyuki et al., 1983; Fujita et al., 1993; Cantwell et al., 2000). Due to malpositioning (up to 30%) in men routine bronchoscopy after double‐lumen tube or bronchial blocker placement is certainly recommended.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Intrathoracic Pressure During Continuous Two‐Lung Ventilation for Thoracoscopy on the Cardiorespiratory Parameters in Sevoflurane Anaesthetized Dogs

Polis

Gasthuys

Gielen

et al. 2002

Journal of Veterinary Medicine Series A

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The cardiopulmonary effects of different levels of carbon dioxide insufflation (3, 5 and 2 mm Hg) under two-lung ventilation were studied in six sevoflurane (1.5 minimum alveolar concentration; MAC) anaesthetized dogs during left-sided thoracoscopy. An arterial catheter, Swan-Ganz catheter and multianaesthetic gas analyser were used to monitor the cardiopulmonary parameters during the experiment. Baseline data were obtained before intrathoracic pressure elevation and the measurements were repeated at intervals after left lung collapse induced by insufflation with carbon dioxide gas. The intrapleural pressure levels used were 3, 5 and 2 mm Hg. Arterial blood pressures, cardiac index, stroke index, left and right ventricular stroke work index, arterial haemoglobin saturation, arterial oxygen tension and systemic vascular resistance decreased significantly during hemithorax insufflation, whereas heart rate, right atrial pressure, mean, systolic and diastolic pulmonary arterial pressure, pulmonary capillary wedge pressure, pulmonary vascular resistance and arterial carbon dioxide tension significantly increased during intrapleural pressure elevation. Although carbon dioxide insufflation into the left hemithorax with an intrapleural pressure of 2-5 mm Hg compromises cardiac functioning in 1.5 MAC sevoflurane anaesthetized dogs, it can be an efficacious adjunct for thoracoscopic procedures. Intrathoracic view was satisfactory with an intrapleural pressure of 2 mm Hg. Therefore, the intrathoracic pressure rise during thoracoscopy with two-lung ventilation should be kept as low as possible. Additional insufflation periods should be avoided, since a more rapid and more severe cardiopulmonary depression can occur.

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“…This animal model thus permitted ventilatory separation of the two lungs with a commercially available double lumen endobronchial tube, which is very difficult in dogs. 12 In Study 1, sevoflurane was administered with increasing concentrations, and not in a randomized sequence. Hence, this design is accompanied by time-effects.…”

Section: Discussionmentioning

confidence: 99%