Effects of amlodipine on exercise tolerance, quality of life, and left ventricular function in patients with heart failure from left ventricular systolic dysfunction

Udelson, James E.; DeAbate, C. Andrew; Berk, Martin R.; Neuberg, Gerald W.; Packer, Milton; Vijay, Nampalli; Gorwitt, Jeffrey; Smith, William B.; Kukin, Marrick; LeJemtel, Thierry H.; Levine, T. Barry; Konstam, Marvin A.; Investigators, Amlodipine Exercise Trial

doi:10.1016/s0002-8703(00)90095-4

Cited by 46 publications

(17 citation statements)

References 21 publications

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“…This was, however, not consistent across all studies [21,22]. In our study we detected an association of the use of calcium channel blockers and mortality.…”

Section: Discussioncontrasting

confidence: 91%

Use of Calcium Channel Blockers is Associated with Mortality in Patients with Chronic Kidney Disease

Haider¹,

Sauter²,

Lindner³

et al. 2015

Kidney Blood Press Res

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Background/Aims: The use of antihypertensive medicines has been shown to reduce proteinuria, morbidity, and mortality in patients with chronic kidney disease (CKD). A specific recommendation for a class of antihypertensive drugs is not available in this population, despite the pharmacodynamic differences. We have therefore analysed the association between antihypertensive medicines and survival of patients with chronic kidney disease. Methods: Out of 2687 consecutive patients undergoing kidney biopsy a cohort of 606 subjects with retrievable medical therapy was included into the analysis. Kidney function was assessed by glomerular filtration rate (GFR) estimation at the time point of kidney biopsy. Main outcome variable was death. Results: Overall 114 (18.7%) patients died. In univariate regression analysis the use of alpha-blockers and calcium channel antagonists, progression of disease, diabetes mellitus (DM) type 1 and 2, arterial hypertension, coronary heart disease, peripheral vascular disease, male sex and age were associated with mortality (all p<0.05). In a multivariate Cox regression model the use of calcium channel blockers (HR 1.89), age (HR 1.04), DM type 1 (HR 8.43) and DM type 2 (HR 2.17) and chronic obstructive pulmonary disease (HR 1.66) were associated with mortality (all p < 0.05). Conclusion: The use of calcium channel blockers but not of other antihypertensive medicines is associated with mortality in primarily GN patients with CKD.

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“…This was, however, not consistent across all studies [21,22]. In our study we detected an association of the use of calcium channel blockers and mortality.…”

Section: Discussioncontrasting

confidence: 91%

Use of Calcium Channel Blockers is Associated with Mortality in Patients with Chronic Kidney Disease

Haider¹,

Sauter²,

Lindner³

et al. 2015

Kidney Blood Press Res

View full text Add to dashboard Cite

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“…Health-related measures were used in 46 studies. In the majority (52%), the measure of choice was the 36-item Short-form Health Survey (SF-36) or some subscale(s) of the SF-36 (24 studies) [61][62][63][64][65]10,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82]. In six studies, this was the only QoL measure used.…”

Section: Resultsmentioning

confidence: 99%

“…This measure was used in 83 (69%) of all studies [61][62][63][64]66,68,71,74,[78][79][80][81][82]85,34,. In 57 (47%) of studies, it was the only measure used.…”

Section: Resultsmentioning

confidence: 99%

“…A partial effect was reported in two studies [61,113]. Fifteen reported no significant differences between medication and placebo [39,63,78,89,101,106,107,111,129,133,139,141,146,149,165]. Four studies were terminated early, two because of a trend towards increased mortality in the treatment arm [112,158], one because of significantly increased survival in the treatment arm [125] and one for reasons not outlined [147].…”

Section: Pharmacological Trialsmentioning

confidence: 99%

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Quality of life assessment in heart failure interventions: a 10-year (1996–2005) review

Morgan

McGee

Shelley

2007

European Journal of Cardiovascular Prevention & Rehabilitat

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The increasing prevalence and poor prognosis associated with heart failure have prompted research to focus on improving quality of life (QoL) for heart failure patients. Research from 1996–2005 was systematically reviewed to identify randomized controlled trials that assessed QoL in heart failure. In 120 studies, 44 were medication trials; 19 surgical/procedural interventions; and 57 patient care/service delivery interventions. Studies were summarized in terms of aim, population, QoL measures used and QoL findings. Studies used 47 different measures of QoL-generic, health-related, condition-specific, domain-specific and utility measures. Most used a single QoL measure. In 87%, a condition specific QoL measure was used, with the Minnesota Living with Heart Failure Questionnaire being the favoured assessment tool. The range of QoL measures in use poses challenges for development of cumulative knowledge. Although comparability across studies is important, this must be informed by the responsiveness of the instrument selected. As carried out in other cardiac groups, comparative evaluations of instrument responsiveness are needed in heart failure. Eur J Cardiovasc Prev Rehabil 14:589-607 © 2007 The European Society of Cardiology

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“…31 Other calcium channel blockers, such as felodipine, nisoldipine, and nicardipine, have resulted in no effects or deterioration of clinical status. 32,33 Amlodipine, another calcium channel blocker, had favorable effects 34 and the clinical trial, PRAISE, disclosed that long-term treatment with amlodipine improved the morbidity and mortality rates in patients with non-ischemic dilated cardiomyopathy. 35 In a murine model of viral myocarditis, amlodipine reduced myocardial inflammation and necrosis, and improved survival.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Low-Dose Benidipine in Acute Autoimmune Myocarditis-Suppressive Effects on Inflammatory Cytokines and Inducible Nitric Oxide Synthase-

Yuan

Kishimoto

Shioji

2003

Circ J

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Effects of amlodipine on exercise tolerance, quality of life, and left ventricular function in patients with heart failure from left ventricular systolic dysfunction

Cited by 46 publications

References 21 publications

Use of Calcium Channel Blockers is Associated with Mortality in Patients with Chronic Kidney Disease

Use of Calcium Channel Blockers is Associated with Mortality in Patients with Chronic Kidney Disease

Quality of life assessment in heart failure interventions: a 10-year (1996–2005) review

Beneficial Effects of Low-Dose Benidipine in Acute Autoimmune Myocarditis-Suppressive Effects on Inflammatory Cytokines and Inducible Nitric Oxide Synthase-

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