Effects of amoxicillin repeated administration on the hemogram and biogram of sheep

[Retracted] Deleterious Effects of Amoxicillin on Immune System and Haematobiochemical Parameters of a Rabbit

“…The increased population of these cells in treated rabbits can be related to different tissue damages by amoxicillin. Different previous studies have also reported similar results in amoxicillin-treated sheep [ 11 ]. The present study showed that granulocytes significantly increased.…”

“…Amoxicillin is a bactericidal aminopenicillin, which eliminates principally by tubular secretion and glomerular filtration. Due to its broad spectrum activity, cheapness, favorable pharmacokinetics, and antimicrobial efficacy, amoxicillin is widely used in the poultry industry [ 10 ] and for preoperative antibiotic prophylaxis in veterinary medicine [ 11 ]. Since antibiotics are associated with adverse effects, the European Union introduced a general prohibition for the use of antibiotics as growth promoters [ 12 ].…”

3Department of Nutrition and food science, Faculty of specific education (Home Economics), Faculty of Medicine; Benha University

“…These results in comparable with (Ragbetli et al, 2009) who recorded that one week after (7 days) treatment of pneumonic calves with tulathromycin (Draxxin®) revealed Ca, K, Na and urea were significantly altered toward the level of healthy animals. Also agreed with (Elmajdoub et al, 2014) who reported that amoxicillin given in the therapeutic dose twice daily to healthy Libyan sheep caused only minor inconclusive changes of biochemical profile of these animals. The results providing the efficacy of the three antibiotic treatment have no adverse effect of the kidney function and restoring the serum electrolytes changes occurred in pneumonic Boer goats secondary to bacterial infections and their toxins.…”

“…The results of hematological changes after treatment with florfenicol agreed with (Ramadan and Abd El-Aty, 2011) who recorded that the hematological parameters returned toward normal levels after second day of intramuscular treatment of florfenicol. The results of hematology after treatment with amoxicillin agreed to (Elmajdoub et al, 2014) who concluded that amoxicillin given in the therapeutic dose twice daily to healthy Libyan sheep caused only minor inconclusive changes in the hematological parameters. Also the changes in hematology and leukocyte count and differential leukocytes that most of them began after the 3 rd day of treatment with tulathromycin providing the earlier recovery of the hematological parameters suggesting the greater efficacy in treatment of pneumonia in Boer goats.…”

“…The improvement in protein profile might be attributed to the increased synthesis of protein in the liver as indicated by the reduction of serum enzymes (ALT and AST) started from the 1 st day of treatment (Altunok et al, 2002, Yazar et al, 2004and Ragbetli et al, 2009. These also providing that treatment with tulathromycin, florfenicol and amoxicillin has no adverse effect on the liver or hepatotoxic effect (Elmajdoub et al, 2014). Then the success of the three antibiotics treatment in reducing IgG and IgA started from the 5 th day of treatment indicate their effectiveness in overcome the inflammatory reaction of infection which is the main cause of hypergammaglobunemia (Apaydin and Dede, 2010).…”