Effects of amphetamine on cell mediated immune response in mice

Effects of Single or Repeated Administrations of Methamphetamine on Immune Response in Mice

“…However, opinions concerning the influence of AMP on NK cell activity are not uniform. House et al [13] and Nunez-Iglesias et al [21] described suppressive effects of AMP on NK cell activity. Wrona et al [29] reported that the increase in corticosterone level, lymphopenia, and neutrocytosis indicated a stress-like reaction to AMP, but no significant correlation between NK cell activity and corticosterone level was found.…”

Effects of single or repeated amphetamine treatment and withdrawal on lung allergic inflammation in rats

“…Stress and drugs that act on Central Nervous System (CNS) are known to influence the onset, course, and treatment of several diseases, including asthma [3][4][5][6]. Amphetamine (AMPH) and its ring-substituted phenylisopropylamine methylenedioxy methamphetamine (Ecstasy) are widely abused drugs that exert profound effects on behavior, biochemistry, and immunity [7][8][9]. AMPH is also commonly used to treat several disorders, including attention deficit, narcolepsy, and obesity [10].…”

Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men

“…Experimental studies have shown that commonly used recreational drugs such as marijuana, cocaine, poppers, and amphetamines have immunomodulatory properties [Baldwin et al, 1998;Klein et al, 1998;Pellegrino and Bayer, 1998;Dax et al, 1991;James, 1999;Kubera et al, 2002;Nunez-Iglesias et al, 1996]. Altered T cell responses to immune challenges such as mitogens, alloantigens, and bacterial infections with exposure to these substances have been observed in vitro and in animal models [Domingues-Junior et al, 2000;Freire-Garabal et al, 1991;Klein et al, 1998;Klein et al, 2004;Kubera et al, 2002;Pellegrino and Bayer, 1998;Dax et al, 1991].…”