2015
DOI: 10.1186/s12916-015-0362-z
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Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial

Abstract: BackgroundExercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue.MethodsThis multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic … Show more

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Cited by 194 publications
(241 citation statements)
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References 29 publications
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“…However, the estimate direction with an effect favorable to the Experimental Group was maintained. These results are similar to those obtained in other studies in which 6 months after surgery women with breast cancer undergoing physiotherapy or a specific exercise program presented better scores, or a higher ratio with clinical improvement when compared to a Control Group (without the intervention of physiotherapy or an exercise program), but there were no statistically significant differences between groups in the Global Health Status [21,23,29], Physical Functioning [23,50], Future Perspective [23], Fatigue [21,23] or Arm Symptoms [23]. However, in other studies, 6 months after surgery women with breast cancer who had the support of physiotherapy or a specific exercise program, compared to a Control Group, showed statistically significant or clinically important improvement in Global Health Status [20,22], Role Functioning [20,22], Emotional Functioning, Social Functioning [22,26], Fatigue [20], Pain [21], Future Perspective, Breast Symptoms, and Arm Symptoms [26].…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…However, the estimate direction with an effect favorable to the Experimental Group was maintained. These results are similar to those obtained in other studies in which 6 months after surgery women with breast cancer undergoing physiotherapy or a specific exercise program presented better scores, or a higher ratio with clinical improvement when compared to a Control Group (without the intervention of physiotherapy or an exercise program), but there were no statistically significant differences between groups in the Global Health Status [21,23,29], Physical Functioning [23,50], Future Perspective [23], Fatigue [21,23] or Arm Symptoms [23]. However, in other studies, 6 months after surgery women with breast cancer who had the support of physiotherapy or a specific exercise program, compared to a Control Group, showed statistically significant or clinically important improvement in Global Health Status [20,22], Role Functioning [20,22], Emotional Functioning, Social Functioning [22,26], Fatigue [20], Pain [21], Future Perspective, Breast Symptoms, and Arm Symptoms [26].…”
Section: Discussionsupporting
confidence: 90%
“…This matches other studies in which 6 months after the surgery, women with breast cancer who did not undergo physiotherapy, when compared to a group who did, registered a greater degradation in the Global Health Status [26,27,51], Physical Functioning, Role Functioning, Emotional and Social Functioning [50,51], Body Image, Future Perspective [26], and Fatigue [51].…”
Section: Discussionsupporting
confidence: 88%
“…Biskup et al, in their study addressing physical activity as a contributive factor in maintaining post-mastectomy health, showed a challenging nature of the research focused on comparing academical studies evaluating overall effectiveness of post-surgical intervention outcomes, while using the diversity of research tools [25]. In the present, systematic review of literature, the research tools applied in the assessment of different components of physical activity differ significantly between studies.…”
Section: Study Limitationsmentioning
confidence: 83%
“…Patients with cancer in particular are often motivated to change their lifestyle after diagnosis and, therefore, already intend to increase physical activity levels or attend an exercise programme in the near future [21]. For example, in the Physical Activity during Cancer Treatment (PACT) study, about 50% of the patients with breast cancer randomized to the control group adopted the behaviour of the intervention group [22]. A high level of contamination due to cross-over of controls who adopt the behaviour of the intervention group may decrease the statistical power to detect an intervention effect.…”
Section: Relative Merits Of the Cmrct Designmentioning
confidence: 99%