Effects of an amylopectin and chromium complex on the anabolic response to a suboptimal dose of whey protein

Abstract

BackgroundPrevious research has demonstrated the permissive effect of insulin on muscle protein kinetics, and the enhanced insulin sensitizing effect of chromium. In the presence of adequate whole protein and/or essential amino acids (EAA), insulin has a stimulatory effect on muscle protein synthesis, whereas in conditions of lower blood EAA concentrations, insulin has an inhibitory effect on protein breakdown. In this study, we determined the effect of an amylopectin/chromium (ACr) complex on changes in plasma concentrations of EAA, insulin, glucose, and the fractional rate of muscle protein synthesis (FSR).MethodsUsing a double-blind, cross-over design, ten subjects (six men, four women) consumed 6 g whey protein + 2 g of the amylopectin-chromium complex (WPACr) or 6 g whey protein (WP) after an overnight fast. FSR was measured using a primed, continuous infusion of ring-d5-phenylalanine with serial muscle biopsies performed at 2, 4, and 8 h. Plasma EAA and insulin were assayed by ion-exchange chromatography and ELISA, respectively. After the biopsy at 4 h, subjects ingested their respective supplement, completed eight sets of bilateral isotonic leg extensions at 80% of their estimated 1-RM, and a final biopsy was obtained 4 h later.ResultsBoth trials increased EAA similarly, with peak levels noted 30 min after ingestion. Insulin tended (p = 0.09) to be higher in the WPACr trial. Paired samples t-tests using baseline and 4-h post-ingestion FSR data separately for each group revealed significant increases in the WPACr group (+0.0197%/h, p = 0.0004) and no difference in the WP group (+0.01215%/hr, p = 0.23). Independent t-tests confirmed significant (p = 0.045) differences in post-treatment FSR between trials.ConclusionsThese data indicate that the addition of ACr to a 6 g dose of whey protein (WPACr) increases the FSR response beyond what is seen with a suboptimal dose of whey protein alone.

Combination of amylopectin and chromium form improves energy storage and reduces muscle fatigue in rats during exhaustive exercise

“…Micronutrients such as A and Cr are efficient in modulating glucose and insulin metabolism (34,(37)(38)(39), as observed in the current study. Indeed, the combination of A and Cr as CrPic elevated blood glucose level while A combined with Cr as CrHis reduced it.…”

“…Group 5 rats received the same amount of elemental Cr but this Cr was half met by CrPic and the other half by CrHis. A and Cr doses were determined on the basis of the studies done by Ziegenfuss et al (34) and Sahin et al (35). Ingredients and nutrient compositions of the diet are shown in Table 1.…”

Biological significance of chromium III for the human organism

“…W 2017 r. opublikowano wyniki pilotażowego badania Ziegenfussa i wsp. [44], w którym analizowano wpływ chromu zastosowanego w postaci kompleksu z amylopektyną na zmiany osoczowego stężenia egzogennych aminokwasów i ułamkową szybkość syntezy białka mięśni (fractional protein synthesis rates -FSR) ocenianą w bioptatach mięśniowych. Autorzy wykazali zwiększenie FSR w grupie suplementowanej.…”

Nutrition tactics to improve post-exercise recovery

“…The rate of exogenous glucose oxidation appears limited by intestinal glucose absorption [12,61]. Glucose is absorbed from the intestine via sodium dependent glucose transporters (SGLT1) [62]. It has been speculated that glucose transport via SGLT1 may become saturated when more than 1-1.1 g•min −1 glucose and glucose polymers are ingested.…”

“…Furthermore, several micronutrients that are present primarily in the yolk, such as vitamin A, vitamin D, vitamin E, zinc, selenium and cholesterol, are potential candidates that may be responsible for the greater anabolic response to feeding [48,61]. In addition, the coingestion of an amylopectin/chromium complex has recently been shown to augment the post-exercise MPS response to the ingestion of a suboptimal amount of protein [62]. However, it should be noted some nutrients may potentially impair MPS when ingested in large amounts in excess of what is typically consumed in the diet.…”