Effects of an aqueous extract of Triticum repens on lipid metabolism in normal and recent-onset diabetic rats

Maghrani, Mhamed; Lemhadri, A.; Zeggwagh, Naoufel Ali; Amraoui, M.; Haloui, Mounsif; Jouad, Hassan; Eddouks, Mohamed

doi:10.1016/j.jep.2003.10.011

Cited by 39 publications

(28 citation statements)

References 12 publications

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“…Diabetes has been reported to be associated with profound alterations in biochemical and normal histology leading to an increased risk of coronary heart disease (Huang et al, 1988;Fontbonne et al, 1989;Motta et al, 2001;Maghrani et al, 2004). In this investigation, the extract was observed to present a similar but more potent effect as compared with the antidiabetic drug (glimepiride) in the restoration of morphological derangement.…”

Section: Discussionmentioning

confidence: 51%

Histological and Histochemical Studies of the Aorta and Pulmonary Trunk in STZ-induced Diabetic Wistar Rats Treated with Momordica charantia

et al. 2013

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Section: Discussionmentioning

confidence: 51%

Histological and Histochemical Studies of the Aorta and Pulmonary Trunk in STZ-induced Diabetic Wistar Rats Treated with Momordica charantia

et al. 2013

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“…24,25 Diabetes is associated with alterations in the plasma lipid and lipoprotein profile, with an increased risk of coronary heart disease. 26 Our data show that the level of HDL was increased, but levels of TC, TG, LDL in the diabetic rats were decreased. These results indicate that MPE possesses hypolipidemic effect in diabetic rats and thus may lead to a decrease in the risk of cardiovascular disease and related complications.…”

Section: Discussionmentioning

confidence: 46%

Hypoglycemic and Hypolipidemic Activities of Ethanolic Extract from Mimosa pudica L. in Normal and Streptozotocin-Induced Diabetic Rats

Yupparach¹,

Konsue²

2017

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Context:Mimosa pudica L. its unique property to collapse when touched and opens up. Aims: To evaluate hypoglycemic and hypolipidemic activities of 80% ethanolic extract from whole plant of Mimosa pudica L. (MPE) by measuring fasting blood glucose in normal and streptozotocin (STZ)-induced diabetic rats treated with MPE. Materials and Methods: An eight-week study using MPE was performed in normal and streptozotocin (STZ)-induced diabetic rats. Hypoglycemic activities in normal and STZ-induced diabetic rats and oral glucose tolerance test (OGTT) and biochemical data include total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) of MPE were compared with glibenclamide, a standard anti-diabetic drug. Results: OGTT showed that MPE did not decrease blood glucose both in normal and STZ-induced diabetic rats comparable to controls and glibenclamide treated rats. Moreover, MPE did not affect FBG in the normal rats. However, it significantly (p<0.05) decreased FBG in the diabetic rats while MPE increased HDL and decreased TC, TG and LDL in the diabetic rats. Conclusions: The results from this study confirmed the traditional use of Mimosa pudica L. for the treatment of diabetes mellitus.

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“…[41][42][43][44] Diabetes has been a great influence on lipid metabolism caused by streptozotocin-induced as a result to increasing of TC and TG levels which observed by impaired with liver function from diabetic rat damage. [44][45] Our data showed improvement of lipid profiles which increased HDL, decreased TC, TG and LDL in the diabetic rats. 15,16,41 The plants could be prevent and treat disorders of diabetes which mainly responsible for mediating the formation by peroxi-dation of unsaturated fatty acids, cholesterol and lipoproteins, increased lipid peroxidation leads to membrane damage and consequently organs dysfunction being this an important risk factor for atherosclerosis and coronary artery disease.…”

Section: Discussionmentioning

confidence: 52%

“…15,16,41 The plants could be prevent and treat disorders of diabetes which mainly responsible for mediating the formation by peroxi-dation of unsaturated fatty acids, cholesterol and lipoproteins, increased lipid peroxidation leads to membrane damage and consequently organs dysfunction being this an important risk factor for atherosclerosis and coronary artery disease. 44,46,[48][49] Decreasing on lipid levels and consequently the reduction of lipid peroxidation were improved due to the high antioxidant potential of polyphenolic compounds that act by mechanisms of reaction inhibition in the peroxidation chain and could be reduce complication resulting from diabetes. [48][49] …”

Section: Discussionmentioning

confidence: 99%

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Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Konsue¹,

Talubmook²

2018

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Context:Abutilon indicum and Mimosa pudica were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. Aims: The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The recipe were composed of whole plants from A. indicum and M. Pudica (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. Results: All doses of the extracts were showed significantly (p<0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (p<0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (p< 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (p< 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. Conclusion: The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.

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Effects of an aqueous extract of Triticum repens on lipid metabolism in normal and recent-onset diabetic rats

Cited by 39 publications

References 12 publications

Histological and Histochemical Studies of the Aorta and Pulmonary Trunk in STZ-induced Diabetic Wistar Rats Treated with Momordica charantia

Histological and Histochemical Studies of the Aorta and Pulmonary Trunk in STZ-induced Diabetic Wistar Rats Treated with Momordica charantia

Hypoglycemic and Hypolipidemic Activities of Ethanolic Extract from Mimosa pudica L. in Normal and Streptozotocin-Induced Diabetic Rats

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

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