Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice

Kimura, Yoshiyuki; Sumiyoshi, Maho

doi:10.1016/j.jep.2012.02.031

Cited by 69 publications

(48 citation statements)

References 42 publications

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“…Taken together these data indicate that the coadministration of CD with l -dopa reduces the potency of l -dopa to suppress gastric emptying of non-nutrient meal. This is likely to reflect the decreased formation of dopamine established to suppress gastric emptying through activation of peripheral D2/D3 receptors in rats [20,22,64]. Indeed, the peripheral AADC inhibitor, CD given in conjunction with l -dopa reduces plasma dopamine levels while increasing those of l -dopa measured 30–90 min after their oral administration at 10/1.5 ratio (200/25 mg kg −1 ) in rats [44] and in humans [43].…”

Section: Discussionmentioning

confidence: 99%

“…However of note since the restorative effect of rikkunshito on LD/CD induced delayed gastric emptying in naïve rats was only partly abolished by ghrelin receptor antagonist, and the rise in circulating ghrelin induced by rikkunshito is rather modest, it is likely that rikkunshito action may involve additional mechanisms. A recent report indicates that Atractylodes lancea rhizome, one of the component contained in rikkunshito, prevents the delayed gastric emptying induced by ip dopamine in mice [22] suggesting an interaction with peripheral D2 receptors which remained to be explored.…”

Section: Discussionmentioning

confidence: 99%

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Preventive effect of rikkunshito on gastric motor function inhibited by l-dopa in rats

et al. 2014

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We previously reported that ghrelin prevented l-dopa (LD)-induced inhibition of gastric emptying (GE) of a non-nutrient solution in rats. Parkinson’s disease treatment involves the combined administration of l-dopa with the enzyme l-amino acid decarboxylase inhibitor, carbidopa (CD) to reduce peripheral formation of dopamine. We investigated the effect LD/CD given orogastrically (og) on GE of a non-nutrient or nutrient meal and whether og pretreatment with rikkunshito, a kampo medicine clinically used to treat gastroparesis, influenced LD/CD effect on GE and postprandial antral and duodenal motility in conscious rats. LD/CD (20/2 mg kg−1) decreased significantly GE to 26.3 ± 6.0% compared to 61.2 ± 3.2% in og vehicle monitored 20-min after a non-nutrient meal and to 41.9 ± 5.8% compared to 72.9 ± 5.2% in og vehicle monitored 60 min after a nutrient meal. Rikkunshito (0.5 or 1.0 g kg−1) reduced the LD/CD (20/2 mg kg−1) inhibition of GE of non-nutrient meal (36.9 ± 7.4% and 46.6 ± 4.8% respectively vs. 12.1 ± 7.4% in og vehicle plus LD/CD) while having no effect alone (56.6 ± 8.5%). The ghrelin antagonist, [d-Lys3]-GHRP-6 (1 mg kg−1) injected intraperitoneally partially reversed rikkunshito preventive effect on LD/CD-inhibited GE. Rikkunshito (1.0 g kg−1) blocked LD/CD (20/2 mg kg−1)-induced delayed GE of a nutrient meal and the reduction of postprandial antral motility. In 6-hydroxydopamine-induced Parkinson’s disease rat model, rikkunshito (1.0 g kg−1, og) also prevented LD/CD-inhibited gastric emptying of a nutrient meal and enhanced fasting plasma levels of acylated ghrelin. These data indicate that oral rikkunshito alleviates the delayed GE induced by LD/CD in naïve and PD rat model in part through ghrelin-related mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preventive effect of rikkunshito on gastric motor function inhibited by l-dopa in rats

et al. 2014

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“…A. macrocephala is cultivated throughout China including Anhui, Fujian, and Hubei provinces, as well as Chongqing city. Due to variations in species, location, and habits, different Atractylodes rhizome plants contain essential oils that differ in terms of composition and concentration of the individual components . Currently, there is still a need for a detailed profile and comparison of the essential oils of different species of Atractylodes rhizome.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of essential oils in Atractylodes lancea and Atractylodes koreana by gas chromatography with mass spectrometry

Liu

Zhang

Yang³

et al. 2016

J of Separation Science

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Atractylodes rhizome is a valuable traditional Chinese medicinal herb that comprises complex several species whose essential oils are the primary pharmacologically active component. Essential oils of Atractylodes lancea and Atractylodes koreana were extracted by hydrodistillation, and the yield was determined. The average yield of essential oil obtained from A. lancea (2.91%) was higher than that from A. koreana (2.42%). The volatile components of the essential oils were then identified by a gas chromatography with mass spectrometry method that demonstrated good precision. The method showed clear differences in the numbers and contents of volatile components between the two species. 41 and 45 volatile components were identified in A. lancea and A. koreana, respectively. Atractylon (48.68%) was the primary volatile component in A. lancea, while eudesma-4(14)-en-11-ol (11.81%) was major in A. koreana. However, the most significant difference between A. lancea and A. koreana was the major component of atractylon and atractydin. Principal component analysis was utilized to reveal the correlation between volatile components and species, and the analysis was used to successfully discriminate between A. lancea and A. koreana samples. These results suggest that different species of Atractylodes rhizome may yield essential oils that differ significantly in content and composition.

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“…Corticosteroids, 5‐aminosalicylic acid, immune modulators, such as thiopurine and methotrexate , biological drugs, and anti‐tumor necrosis factor (TNF) antibody are used for the treatment of IBD in both CD and UC patients. We previously reported that Swertia japonica extract and its main compound swertiamarine, and Atractylodes lancea rhizome extract and a volatile component β‐eudesmol stimulated gastric emptying and/or small intestine motility by inhibiting the dopamine D 2 and/or 5‐HT receptor . The present study investigated the effects of KST on 5‐HT‐induced diarrhea and dextran sulfate sodium (DSS)‐induced colitis in mice.…”

Section: Introductionmentioning

confidence: 90%

Effects of kampo medicine keishikashakuyakuto on large intestine disease in mice

Kimura

2019

Traditional & Kampo Medicine

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Aim The aim of this study was to examine the effects of keishikashakuyakuto (KST) on large intestine diarrhea and inflammation in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) mouse models. Methods This study examined the effects of KST on diarrhea and inflammatory bowel syndrome using 5‐hydroxytryptamine (5‐HT)‐induced diarrhea and 3% dextran sulfate sodium (DSS)‐treated colitis models. Results Keishikashakuyakuto (200 and/or 500 mg/kg) and ramosetron (5 μg/kg) prolonged the onset‐time of 5‐HT‐induced diarrhea in mice. KST and ramosetron prevented diarrhea and the stool score was decreased 60 min after 5‐HT treatment. The disease activity index in the 3% DSS‐treated mice was lower after oral KST than in mice given 3% DSS only. Furthermore, KST inhibited the decreases in red cells and platelets, and in hemoglobin and hematocrit that were observed in DSS‐treated mice. On colon histology using hematoxylin–eosin and direct fast scarlet staining, KST prevented the mucosa membrane ulceration and eosinophil infiltration of the mucosa membrane caused by DSS treatment. The increase in colonic monocyte chemoattractant protein 1, interleukin‐1β and tumor necrosis factor‐α in DSS‐treated mice was reduced by oral KST. Conclusion Keishikashakuyakuto may be effective for IBS and IBD.

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Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice

Cited by 69 publications

References 42 publications

Preventive effect of rikkunshito on gastric motor function inhibited by l-dopa in rats

Preventive effect of rikkunshito on gastric motor function inhibited by l-dopa in rats

Differentiation of essential oils in Atractylodes lancea and Atractylodes koreana by gas chromatography with mass spectrometry

Effects of kampo medicine keishikashakuyakuto on large intestine disease in mice

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