Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids and Vitamin D Serum Levels in Double-Blinded, Randomized, Controlled Trials in Healthy and Crohn’s Disease Populations

Laing, Bobbi; Cavadino, Alana; Ellett, Stephanie; Ferguson, Lynnette R.

doi:10.3390/nu12041139

Cited by 12 publications

(6 citation statements)

References 106 publications

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“…[5] found that fish oil preparation that limits the side effects of traditional fish oil therapy shows promise as an adjunctive treatment for Crohn's disease. Omega 3 fatty acids reduce intestinal inflammation, induce and maintain clinical remission in UC patients, and are related with the reduction of pro inflammatory cytokines, decrease disease activity and increase the quality of life of CD patients [4,32]. In conclusion, since results of our study showed that omega 3 given orally had beneficial effects on Crohn's rats, so, it could be recommended that omega 3 supplementation might be worthy protecting for Crohn's disease patients.…”

Section: Resultsmentioning

confidence: 61%

effective role of vitamin D and omega-3 on rats with induced Crohn’s disease

Rabeh

Ibrahim

Osman

2022

ijhs

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Crohn's disease is an irreversible inflammatory disease, mainly affecting the gastrointestinal tract. The aim of present study was to investigate the effect of dietary vitamin D and omega 3 supplementation on rats with induced Crohn’s disease. Twenty – four adult male albino rats weighing (160 gm) were divided into 4 groups. The 1st group (n=6) was fed on the basal diet. The 2nd to 4th of rats (n=18) were injected with (10 mg/kg for 3 days) of indomethacin at the end of the experiment to induce Crohn’s disease. Groups (3 and 4) were fed on basal diet and given orally 1000/IU/kg/ b.w. of vitamin D and 600 mg/kg/b.w. of omega 3 respectively. At the end of the experimental period (8 weeks), rats were scarified. Biochemical analysis of the tested parameters was determined. The Results indicated that indomethacin Crohn’s rats showed a significant (P< 0.05) decrease in serum albumin, serum Catalase and serum Glutathione peroxidase compared to the negative control one, while serum liver function, MDA, CRP, and immunity proteins were significantly increased.

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Section: Resultsmentioning

confidence: 61%

effective role of vitamin D and omega-3 on rats with induced Crohn’s disease

Rabeh

Ibrahim

Osman

2022

ijhs

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“…Additionally, supplementation with krill oil, probiotics, and vitamin D decreased inflammation in mice [32]. Dual supplementation of n-3 FAs and vitamin D in more severe cases of inflammatory disease may lack effects, as this showed no effect on hs-CRP in healthy and Crohn's disease populations [33]. Here, we hypothesize that a dietary supplement consisting of probiotics, EPA + DHA, and vitamin D would help combat systemic inflammation in individuals with overweight and obesity by strengthening the intestinal barrier.…”

Section: The Potential Of Dietary Supplementsmentioning

confidence: 99%

Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial

Kopp,

Schweinlin,

Tingö

et al. 2023

IJMS

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Obesity is characterized by low-grade inflammation and increased gut permeability. Here, we aim to evaluate the effect of a nutritional supplement on these parameters in subjects with overweight and obesity. A double-blinded, randomized clinical trial was conducted in 76 adults with overweight or obesity (BMI 28 to 40) and low-grade inflammation (high-sensitivity C-reactive protein (hs-CRP) between 2 and 10 mg/L). The intervention consisted of a daily intake of a multi-strain probiotic of Lactobacillus and Bifidobacterium, 640 mg of omega-3 fatty acids (n-3 FAs), and 200 IU of vitamin D (n = 37) or placebo (n = 39), administered for 8 weeks. hs-CRP levels did not change post-intervention, other than an unexpected slight increase observed in the treatment group. Interleukin (IL)-6 levels decreased in the treatment group (p = 0.018). The plasma fatty acid (FA) levels of the arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio and n-6/n-3 ratio (p < 0.001) decreased, and physical function and mobility improved in the treatment group (p = 0.006). The results suggest that hs-CRP may not be the most useful inflammatory marker, but probiotics, n-3 FAs, and vitamin D, as non-pharmaceutical supplements, may exert modest effects on inflammation, plasma FA levels, and physical function in patients with overweight and obesity and associated low-grade inflammation.

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“…However, ω-3 fatty acids exhibit contradictory effects. Combined supplementation of ω-3 fatty acids and vitamin D does not significantly improve CD inflammation and clinical remission ( 226 ). Multicenter randomized controlled trials have demonstrated the ineffectiveness of using free ω-3 fatty acids for preventing CD relapse ( 227 ).…”

Section: Therapeutic Approaches Based On Fatty Acidsmentioning

confidence: 99%

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

Yan,

Ye,

et al. 2023

Front. Immunol.

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Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though the pathogenesis of IBD remains unclear, diet is increasingly recognized as a pivotal factor influencing its onset and progression. Fatty acids, essential components of dietary lipids, play diverse roles in IBD, ranging from anti-inflammatory and immune-regulatory functions to gut-microbiota modulation and barrier maintenance. Short-chain fatty acids (SCFAs), products of indigestible dietary fiber fermentation by gut microbiota, have strong anti-inflammatory properties and are seen as key protective factors against IBD. Among long-chain fatty acids, saturated fatty acids, trans fatty acids, and ω-6 polyunsaturated fatty acids exhibit pro-inflammatory effects, while oleic acid and ω-3 polyunsaturated fatty acids display anti-inflammatory actions. Lipid mediators derived from polyunsaturated fatty acids serve as bioactive molecules, influencing immune cell functions and offering both pro-inflammatory and anti-inflammatory benefits. Recent research has also highlighted the potential of medium- and very long-chain fatty acids in modulating inflammation, mucosal barriers, and gut microbiota in IBD. Given these insights, dietary intervention and supplementation with short-chain fatty acids are emerging as potential therapeutic strategies for IBD. This review elucidates the impact of various fatty acids and lipid mediators on IBD and delves into potential therapeutic avenues stemming from these compounds.

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Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids and Vitamin D Serum Levels in Double-Blinded, Randomized, Controlled Trials in Healthy and Crohn’s Disease Populations

Cited by 12 publications

References 106 publications

effective role of vitamin D and omega-3 on rats with induced Crohn’s disease

effective role of vitamin D and omega-3 on rats with induced Crohn’s disease

Potential Modulation of Inflammation and Physical Function by Combined Probiotics, Omega-3 Supplementation and Vitamin D Supplementation in Overweight/Obese Patients with Chronic Low-Grade Inflammation: A Randomized, Placebo-Controlled Trial

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

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