Effects of an Oral Elemental Nutritional Supplement on Post-gastrectomy Body Weight Loss in Gastric Cancer Patients: A Randomized Controlled Clinical Trial

Imamura, Hiroshi; Nishikawa, Kazuhiro; Kutsukake, Kentaro; Inoue, Kentaro; Matsuyama, Jin; Akamaru, Yusuke; Kimura, Yutaka; Tamura, Shigeyuki; Kawabata, Ryohei; Kawada, Junji; Fujiwara, Yoshiyuki; Kawase, Takakazu; Fukui, Junichi; Takagi, Mari; Takeno, Atsushi; Shimokawa, Toshio

doi:10.1245/s10434-016-5221-4

Cited by 77 publications

(77 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, these results suggested that CONUT may be not only an oncological predictor but also a comprehensive prognostic marker that accounts for the long-term nutritional effect after gastrectomy compared with other markers. Regarding nutritional supplementation after gastrectomy, many trials have reported on omega-3 fatty acid-supplemented immunonutrition [15] and elemental nutrition [16], but have so far found the clinical benefit of such supplementation to be limited. It may be important to select patients who require intensive nutritional support after gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Clarifying the mechanisms of sarcopenia in patients with cancer may help reveal the mechanism of cachexia, the root of cancer death. Previous studies have shown that various methods of nutritional support are effective for improving dietary intake and outcomes in patients who lose weight after surgery (21,22). Hatao et al found that the use of oral nutritional supplements after total gastrectomy significantly diminished postoperative weight loss (21).…”

Section: Discussionmentioning

confidence: 99%

Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor

et al. 2018

View full text Add to dashboard Cite

Sarcopenia has been reported to relate to poor prognosis in various malignant cancer types. The present study aimed to clarify the prognostic impact of skeletal muscle mass (SMM) loss after curative gastrectomy in patients with gastric cancer. A total of 119 patients who underwent curative gastrectomy for gastric cancer between 2009 and 2016 were analyzed. The SMM loss at 6 months postoperatively compared with the SMM prior to surgery was calculated using the hospital records. The median loss of SMM was 3.8%. Multivariate logistic regression analysis demonstrated that total gastrectomy was a significant and independent risk factor for SMM loss of ≥5% (odds ratio=2.58; P=0.02). Results from multivariate analysis using stepwise Cox proportional hazards regression indicated that the following factors were significantly associated with shorter overall survival after curative gastrectomy: Age [>70 years; hazard ratio (HR)=2.46, P=0.04], TNM stage (≥2; HR=2.65, P=0.04) and loss of SMM (≥5%; HR=2.57, P=0.03). The present findings suggested that loss of SMM after curative gastrectomy for gastric cancer is an independent predictive factor for poor prognosis.

show abstract

“…In this study, we examined patients registered in an original multicenter randomized phase II trial who underwent curative DG or TG for gastric adenocarcinoma at the participating hospitals. Details of the original trial have been reported previously . The original study was conducted in accordance with the World Medical Association Declaration of Helsinki, and the protocol was approved by the institutional review board of each hospital.…”

Section: Methodsmentioning

confidence: 99%

Long‐term effects of an oral elemental nutritional supplement on post‐gastrectomy body weight loss in gastric cancer patients (KSES002)

Kimura

Nishikawa

Kutsukake

et al. 2019

Annals of Gastroent Surgery

Self Cite

View full text Add to dashboard Cite

Aim:The present study aimed to evaluate the efficacy of short-term nutritional intervention with an oral elemental diet (ED; Elental; EA Pharma Co., Ltd, Tokyo, Japan) at 300 kcal/day for 6-8 weeks in the early post-gastrectomy period on postoperative long-term body weight loss (BWL). Methods:We analyzed consecutive patients who were randomly divided to receive the regular diet with or without ED. The control group received regular diet alone post-gastrectomy, whereas the ED group received 300 kcal ED plus regular diet for 6-8 weeks. Primary endpoint was percentage (%) BWL (body weight loss; body weight before surgery minus that at postoperative 1 year) by surgical type. Secondary endpoints included changes in nutrition-related blood parameters.Results: Of the patients in the original trial, 106 were eligible for efficacy analyses. %BWL at postoperative 1 year was significantly lower in the ED group than in | 649 KIMURA et Al.

show abstract

Effects of an Oral Elemental Nutritional Supplement on Post-gastrectomy Body Weight Loss in Gastric Cancer Patients: A Randomized Controlled Clinical Trial

Abstract: ED supplementation reduced postoperative weight loss in gastric cancer patients undergoing gastrectomy.

Cited by 77 publications

References 24 publications

Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection

Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection

Loss of skeletal muscle mass after curative gastrectomy is a poor prognostic factor

Long‐term effects of an oral elemental nutritional supplement on post‐gastrectomy body weight loss in gastric cancer patients (KSES002)

Contact Info

Product

Resources

About