Effects of an oral interferon-inducer on the hematopoietic and reticuloendothelial systems

Rohovsky, M. W.; Newberne, James W.; Gibson, John P.

doi:10.1016/0041-008x(70)90215-2

Cited by 17 publications

(5 citation statements)

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“…This feature was generally absent in NA cells from untreated animals or from A cells. These inclusion bodies have been reported in peripheral lymphocytes of tilorone and BL-20803-treated rats (18,19). A cells from both dosed and undosed mice contained mainly large macrophage-like cells, many with closely adhering smaller mononuclear cells.…”

Section: Resultsmentioning

confidence: 63%

In vivo and in vitro stimulation of mouse spleen leukocytes by BL-20803, a low-molecular-weight interferon inducer

Siminoff¹

1975

Infect Immun

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BL-20803, a low-molecular-weight compound, although able to elicit circulating interferon in the mouse, failed to protect cultured cell lines in vitro from infection by interferon-sensitive viruses. Of the tissues analyzed for interferon content after oral administration of the drug to mice, spleen and lung contained the largest amounts of the virus inhibitor. Spleen cells from such dosed animals when isolated into in vitro cultures elaborated small amounts of interferon into the culture medium. The time sequence of acquisition by spleen cells of the ability to produce interferon closely correlated with the kinetics of development of the circulating interferon response in the intact mouse. When spleen cells were separated on the basis of adherence or nonadherence to a plastic surface, the bulk of the interferon activity was found to be associated with the adherent cells. Upon exposure to BL-20803 in cell culture, adherent cells and, to a lesser extent, nonadherent cells from untreated mice were stimulated to produce interferon-like activity. The biological behavior of BL-20803 is shown to have striking similarities with that of the structurally different low-molecular-weight inducer tilorone hydrochloride.

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Section: Resultsmentioning

confidence: 63%

In vivo and in vitro stimulation of mouse spleen leukocytes by BL-20803, a low-molecular-weight interferon inducer

Siminoff¹

1975

Infect Immun

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“…In the experiment of Rohovsky el al. [7], these cells were found to be markedly affected by T. The reason for the discrepancy cannot be determined.…”

Section: Discussionmentioning

confidence: 58%

“…It protected mice against a varie ty of infections with DNA and RNA viruses [3], During the preliminary toxicologic evaluation R ohovsky et al [7] discovered the appearance of abnormal mononuclear cells in the peripheral blood of laboratory ani mals. Basophil granules and vacuoles were often present in the proto plasm of these cells.…”

mentioning

confidence: 99%

Effect of Tilorone HCI, an Oral Interferon-Inducer, on Leukopoiesis in Rats

Zbinden

Emch

1972

Acta Haematol

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Single oral doses of 100 mg/kg T to rats caused marked lymphopenia. Recovery started after 12 h and was accompanied by depletion of small lymphocytes in lymph follicles of the spleen and the appearance of young lymphocytes with vacuoles and basophil granules in smears of lymph nodes and spleen. Abnormal mononuclear cells whose protoplasm often contained vacuoles and basophil granules appeared in the blood after 48 h. They disappeared in the course of 2–3 weeks. The granulocytic system responded to T with a short-lasting leukocytosis, a shift to left and appearance of basophil granules in neutrophil and eosinophil promyelocytes and myelocytes. Repeated administration of T caused only minor hematologic changes. No other organs were affected by the drug.

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“…Method B. In a typical example, a mixture of 30.0 g (0.074 mol) of VI, 100 ml of diethylamine, 2 g of KI, and 250 ml of THF was stirred and heated in a Parr bomb for 24 hr at approximately 100°. The reaction mixture was concentrated in uacuo to semidryness and then diluted with 1 1. of H2O.…”

Section: Methodsmentioning

confidence: 99%

Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones

Albrecht¹,

Fleming²,

Horgan³

et al. 1974

J. Med. Chem.

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Effects of an oral interferon-inducer on the hematopoietic and reticuloendothelial systems

Cited by 17 publications

References 0 publications

In vivo and in vitro stimulation of mouse spleen leukocytes by BL-20803, a low-molecular-weight interferon inducer

In vivo and in vitro stimulation of mouse spleen leukocytes by BL-20803, a low-molecular-weight interferon inducer

Effect of Tilorone HCI, an Oral Interferon-Inducer, on Leukopoiesis in Rats

Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones

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