Effects of angiotensin I-converting enzyme inhibitor and angiotensin II type 1 receptor blocker on the right ventricular sarcoglycans and dystrophin after left coronary artery ligation

Takahashi, Masaya; Tanonaka, Kouichi; Yoshida, Hiroyuki; Koshimizu, Miki; Oikawa, Ryo; Daicho, Takuya; Takeo, Satoshi

doi:10.1016/j.ejphar.2005.08.031

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…As LV dysfunction becomes chronic, the hyperfunctioning right ventricle progresses to a hypofunctioning state with reduced Ca 2+ uptake. Administration of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in subjects with LV heart failure (HF) reduces the severity of concomitant RV pathologic remodeling noted at microscopic levels [ 16 ]. Chamber-specifi c differences in sympathetic nervous system behavior in animals with HF are also supported by compensatory increases in RV catecholamine stores [ 12 ] and adenyl cyclase coupled β -receptor responsiveness [ 13 ], with chamber-specifi c alterations in β -receptor density [ 14 ].…”

Section: Introduction New Insights Into Rv Embryology Structure Andmentioning

confidence: 99%

Right-sided heart failure: Diagnosis and treatment strategies

Cowger

Dardas²,

Dorsch³

et al. 2008

Curr Treat Options Cardiovasc Med

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Right ventricular (RV) dysfunction in the setting of cardiomyopathy, ischemia, and pulmonary hypertension is associated with high morbidity and mortality, but therapeutic clinical trials examining RV failure as a primary outcome are lacking. This review focuses on the ontologic, morphologic, and microscopic differences between the right and left ventricles. It also discusses the rationale and potential risks associated with the extrapolation of medical therapies used in left ventricular failure and pulmonary arterial hypertension management to the treatment of RV failure. Finally, it introduces the reader to new echocardiographic techniques that may be used to diagnose clinical and subclinical RV systolic and diastolic dysfunction. Given the anticipated rise in the prevalence of RV dysfunction, more studies are needed to gain a better understanding of RV cellular and subcellular function and its response to pathologic stressors and disease so that therapeutic targets can be devised to improve RV failure morbidity and mortality.

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Section: Introduction New Insights Into Rv Embryology Structure Andmentioning

confidence: 99%

Right-sided heart failure: Diagnosis and treatment strategies

Cowger

Dardas²,

Dorsch³

et al. 2008

Curr Treat Options Cardiovasc Med

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“…To date, there are various myocardial ischemic animal models, such as ligating the coronary artery [6] , placing constrictors on the coronary artery [7] , putting microembolus into the coronary artery [8] , or injecting ferric chloride via the vein [9] . However, operations in these methods lead to much damage in animals, and channelization can not be restored in the obstructed coronary artery.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of diltiazem reevaluated by a novel myocardial ischemic model in Chinese miniature swine

Liu

et al. 2007

Acta Pharmacol Sin

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“…In addition, the trauma may render successful recovery from anesthesia in models of myocardial infarction more difficult, compared with closed chest procedures. Besides, to date, there are various myocardial ischemic animal models, such as ligating the coronary artery (Takahashi et al, 2005), placing constrictors on the coronary artery (Laham et al, 2000), putting microembolus into the coronary artery (Huang et al, 2004), or injecting ferric chloride via the vein (Dogne et al, 2005). However, operations in these methods lead to much damage in animals, and channelization can not be restored in the obstructed coronary artery.…”

Section: Acute Ischemic and Reperfusion Animal Modelsmentioning

confidence: 99%