Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition

Byrnes, Valerie; Miller, Amitai S.; Lowry, Damien; Hill, Erin N.; Weinstein, Cheryl S.; Alsop, David C.; Lenkinski, Robert E.; Afdhal, Nezam H.

doi:10.1016/j.jhep.2011.09.015

Cited by 91 publications

(77 citation statements)

References 27 publications

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“…Some studies have managed to show that these neurocognitive damages are a consequence of the HCV infection itself, regardless of comorbidities [29]. Functional imaging methods have shown metabolic changes in brains of chronic hepatitis C patients, with improvement of cognitive function and brain metabolism observed after treating the HCV infection [30]. Some of these disorders such as depression and fatigue are important because they can exacerbate under interferon therapy.…”

Section: Neuropsychiatric Disordersmentioning

confidence: 99%

Extrahepatic Manifestations of Hepatitis C Virus Infection

Jukić¹,

Kralj²

2017

Update on Hepatitis C

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Chronic hepatitis C virus (HCV) infection causes progressive liver fibrosis, cirrhosis, liver failure, and hepatocellular carcinoma. Additional to liver damage, HCV infection causes a variety of systemic disorders, some of which sometimes bear more severe morbidity than the liver disease itself. These extrahepatic manifestations represent a wide spectrum of disorders, ranging from the presence of a variety of clinically insignificant autoantibodies to diseases affecting a variety of organ systems. Mixed cryoglobulinemia is a common manifestation, and associated vasculitis can affect many organs (kidney, skin, and joints). The skin can also be affected by porphyria cutanea tarda and lichen planus. Other common extrahepatic manifestations include autoimmune disorders, lymphoproliferative disorders, and a number of neurological and neuropsychiatric disorders such as fatigue, depression, or cognitive impairment. Insulin resistance, diabetes mellitus, accelerated atherosclerosis, and increased cardiovascular disease morbidity and mortality have also been associated with chronic HCV infection. The existence and severity of extrahepatic manifestations do not correlate with the severity of liver disease, and the mainstay of treatment is HCV eradication. Patients with systemic manifestations of HCV infection should be prioritized for treatment, especially in the era of new interferon-free therapies with fewer side effects.

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Section: Neuropsychiatric Disordersmentioning

confidence: 99%

Extrahepatic Manifestations of Hepatitis C Virus Infection

Jukić¹,

Kralj²

2017

Update on Hepatitis C

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“…115 The eradication of HCV is associated with improvement not only of CNS symptoms but also of brain metabolism, as demonstrated by MRI. 10 …”

Section: Neurocognitive Impairmentmentioning

confidence: 99%

“…8,9 More recently, the central nervous system (CNS) involvement of HCV infection resulting in impairment of several neurocognitive functions has been substantiated by clinical studies coupled with brain imaging investigations, leading to the demonstration that such a dysfunction was reversible on treatment-related clearance of HCV. 10 …”

Section: Introductionmentioning

confidence: 99%

Extrahepatic Manifestations of Hepatitis C Virus

Viganò

Colombo

2015

Gastroenterology Clinics of North America

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“…Pro-inflammatory cytokines may have a mechanistic role in the pathogenesis of fatigue and neuropsychological symptoms in disorders associated with immune activation [98]. A recent pilot study demonstrated improvement in cerebral metabolism and selective aspects of neurocognitive function when non-cirrhotic patients infected with hepatitis C were treated with pegylated interferon and ribavirin and achieved viral clearance [99]. This result suggests that the neuropsychological impairments in HCV infection may be reversible.…”

Section: Central Nervous System Disorders With Hepatitis C Infectionmentioning

confidence: 99%

Neurological Complications of Hepatitis C Infection

McCarthy

Ortega

2012

Curr Neurol Neurosci Rep

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Though well-known as a cause of liver disease, Hepatitis C virus infection is emerging as a cause of a variety of peripheral and central nervous system disorders. The virus causes chronic persistent infection with complex immune responses in the majority of individuals. Viral infection may have the potential to generate neurological illness through direct infection of neural cells or through immune-mediated mechanisms, including enhancement of autoimmune responses. Moreover, the mainstay of antiviral treatment of hepatitis C infection, interferon-alpha, is itself associated with neurological morbidity. Thus neurologists are increasingly faced with diagnosing or even predicting a wide spectrum of neurological complications of hepatitis C infection and/or its treatment.

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Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition

Cited by 91 publications

References 27 publications

Extrahepatic Manifestations of Hepatitis C Virus Infection

Extrahepatic Manifestations of Hepatitis C Virus Infection

Extrahepatic Manifestations of Hepatitis C Virus

Neurological Complications of Hepatitis C Infection

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