Effects of Antidepressants on Weight and on the Plasma Levels of Leptin, TNF-α and Soluble TNF Receptors A Longitudinal Study in Patients Treated with Amitriptyline or Paroxetine

Hinze-Selch, D.; Schuld, Andreas; Kraus, Thomas; Kühn, Martin; Uhr, Manfred; Haack, Monika; Pollmächer, Thomas

doi:10.1016/s0893-133x(00)00089-0

Cited by 131 publications

(96 citation statements)

References 31 publications

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“…Increases of morning leptin levels were found concomitantly with weight gain during treatment of schizophrenic patients with olanzapine (Kraus et al, 1999) and of depressed patients with mirtazapine (Kraus et al, 2002). In contrast, leptin morning levels remained unchanged in depressed patients during treatment with amitriptyline despite weight gain (Hinze-Selch et al, 2000). The stronger effect in our study compared to the overfeeding of controls (Ravussin et al, 2001) may underline that changes of ghrelin are easier to detect by nocturnal sampling than by single blood samples.…”

Section: Discussionsupporting

confidence: 39%

Changes of Sleep Architecture, Spectral Composition of Sleep EEG, the Nocturnal Secretion of Cortisol, ACTH, GH, Prolactin, Melatonin, Ghrelin, and Leptin, and the DEX-CRH Test in Depressed Patients during Treatment with Mirtazapine

Schmid

Wichniak

Uhr

et al. 2005

Neuropsychopharmacol

146

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The noradrenergic and specific serotoninergic antidepressant mirtazapine improves sleep, modulates hormone secretion including blunting of hypothalamic-pituitary-adrenocortical (HPA) activity, and may prompt increased appetite and weight gain. The simultaneous investigation of sleep electroencephalogram (EEG) and hormone secretion during antidepressive treatment helps to further elucidate these effects. We examined sleep EEG (for later conventional and quantitative analyses) and the nocturnal concentrations of cortisol, adrenocorticotropin (ACTH), growth hormone (GH), prolactin, melatonin and the key factors of energy balance, ghrelin, and leptin before and after 28 days of treatment of depressed patients (seven women, three men, mean age 39.974.2 years) with mirtazapine. In addition, a sleep EEG was recorded at day 2 and the dexamethasone-corticotropin-releasing hormone (DEX-CRH) test was performed to assess HPA activity at days À3 and 26. Psychometry and mirtazapine plasma concentrations were measured weekly. Already at day 2, sleep continuity was improved. This effect persisted at day 28, when slow-wave sleep, low-delta, theta and alpha activity, leptin and (0300-0700) melatonin increased, and cortisol and ghrelin decreased. ACTH and prolactin remained unchanged. The first two specimens of GH collected after the start of quantitative EEG analysis were reduced at day 28. The DEX-CRH test showed, at day 26, a blunting of the overshoot of ACTH and cortisol found at day À3. The Hamilton Depression score decreased from 32.177.3 to 15.576.7 between days À1 and 28. A weight gain of approximately 3 kg was observed. This unique profile of changes is compatible with the action of mirtazapine at 5-HT-2 receptors, at presynaptic adrenergic alpha 2 receptors, at the HPA system, and on ghrelin and leptin.

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Section: Discussionsupporting

confidence: 39%

Changes of Sleep Architecture, Spectral Composition of Sleep EEG, the Nocturnal Secretion of Cortisol, ACTH, GH, Prolactin, Melatonin, Ghrelin, and Leptin, and the DEX-CRH Test in Depressed Patients during Treatment with Mirtazapine

Schmid

Wichniak

Uhr

et al. 2005

Neuropsychopharmacol

146

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“…It was suggested that psychotropic drugs which cause weight gain, activate the TNF-α system (14) and thus the TNF-α system is an early and sensitive indicator of weight gain (15 (17). (20) (19,(23)(24)(25)(26).…”

Section: Methodsmentioning

confidence: 99%

Nutritional Approach to Metabolic Changes Arising Out of Schizophrenia Therapy: Case Report

et al. 2007

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“…Seus efeitos no estado nutricional foram estudados principalmente no final da década de 1970. Atualmente, essa classe de drogas é avaliada em relação às mais novas 17,18 .…”

Section: Antidepressivos Tricíclicos (Adt)unclassified

“…O índice de massa corporal -IMC do grupo que recebeu amitriptilina/nortriptilina foi maior (26,2, DP=4,2kg/m 2 ), comparado com o grupo placebo (22,6, DP=2,6kg/m 2 ), enquanto o IMC do grupo com paroxetina foi intermediário (23,7, DP=4,1kg/m 2 ) e não diferiu significativamente dos outros 2 grupos. O aumento no peso corporal e no IMC ocorreu na 6ª semana 18 .…”

Section: Antidepressivos De Classes Diferentesunclassified

Antidepressivos e alterações no peso corporal

et al. 2008

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A depressão é uma doença que pode levar a mudanças no peso, influenciadas por fatores específicos da doença, como alterações no apetite e na atividade física, ou pelos antidepressivos. Este artigo objetiva analisar os estudos que descrevem os efeitos dos antidepressivos em alterações do peso corporal. Realizou-se uma pesquisa nas bases de dados Medline, Lilacs e Cochrane, utilizando as palavras chaves "antidepressivo" e "peso". Foram selecionados os estudos que analisaram o tema em pacientes depressivos, priorizando-se aqueles relacionados às drogas mais utilizadas nos serviços de saúde no Brasil. A análise dos estudos indicou que a mudança de peso atribuída ao tratamento com antidepressivos apresenta resultados ainda controversos, sendo influenciada por fatores como o tempo de uso e a dosagem do medicamento, estudos com poder limitado, entre outros. Assim, estudos com maior poder, tendo como foco a ação das drogas antidepressivas nas alterações do peso corporal em pacientes depressivos, ainda são necessários. Termos de indexação:Antidepressivos. Ganho/Perda de peso. Peso corporal. A B S T R A C T Depression is a disorder that may affect patient's weight because of specific factors of the disease, such as changes in appetite and

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Effects of Antidepressants on Weight and on the Plasma Levels of Leptin, TNF-α and Soluble TNF Receptors A Longitudinal Study in Patients Treated with Amitriptyline or Paroxetine

Cited by 131 publications

References 31 publications

Changes of Sleep Architecture, Spectral Composition of Sleep EEG, the Nocturnal Secretion of Cortisol, ACTH, GH, Prolactin, Melatonin, Ghrelin, and Leptin, and the DEX-CRH Test in Depressed Patients during Treatment with Mirtazapine

Changes of Sleep Architecture, Spectral Composition of Sleep EEG, the Nocturnal Secretion of Cortisol, ACTH, GH, Prolactin, Melatonin, Ghrelin, and Leptin, and the DEX-CRH Test in Depressed Patients during Treatment with Mirtazapine

Nutritional Approach to Metabolic Changes Arising Out of Schizophrenia Therapy: Case Report

Antidepressivos e alterações no peso corporal

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