Effects of Antiepileptic Drugs on Bone Health and Growth Potential in Children with Epilepsy

Vestergaard, Peter

doi:10.1007/s40272-014-0115-z

Cited by 45 publications

(20 citation statements)

References 70 publications

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“…Our study reemphasizes that long‐term AED polytherapy intake (>1 AED) is an important risk factor for children with epilepsy to develop vitamin D deficiency. Our findings are similar with those of other studies showing the negative impact of AED polytherapy and support the results of other studies showing that AED polytherapy exerted a negative impact on bone mineral density . This highlights the importance for clinicians to avoid treating children with AED polytherapy whenever possible due to adverse effects to bone health.…”

Section: Discussionsupporting

confidence: 91%

Vitamin D deficiency and its risk factors in Malaysian children with epilepsy

Fong

Kong

Poh³

et al. 2016

Epilepsia

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Section: Discussionsupporting

confidence: 91%

Vitamin D deficiency and its risk factors in Malaysian children with epilepsy

Fong

Kong

Poh³

et al. 2016

Epilepsia

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“…Further studies will be needed to understand these epigenetic changes in biological and clinical perspectives. Nonetheless, it is noteworthy that many clinical studies have suggested that chronic epilepsy or perhaps the long-term use of antiepileptic drugs may cause growth/developmental problems in children, while abnormal steroid hormone metabolism and certain forms of osteopathy are noted in patients under drug treatments7475767778. In the current cohort of male and female patients and controls, the mean ages were 25 to 35 years, while one-third of the patients with epilepsy onset before 12 year-old (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy

Long

Feng

Kang

et al. 2017

Sci Rep

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Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little is known whether it is associated with peripheral epigenetic changes. Here we compared blood whole genomic DNA methylation pattern in MTLE patients (n = 30) relative to controls (n = 30) with the Human Methylation 450 K BeadChip assay, and explored genes and pathways that were differentially methylated using bioinformatics profiling. The MTLE and control groups showed significantly different (P < 1.03e-07) DNA methylation at 216 sites, with 164 sites involved hyper- and 52 sites hypo- methylation. Two hyper- and 32 hypo-methylated sites were associated with promoters, while 87 hyper- and 43 hypo-methylated sites corresponded to coding regions. The differentially methylated genes were largely related to pathways predicted to participate in anion binding, oxidoreductant activity, growth regulation, skeletal development and drug metabolism, with the most distinct ones included SLC34A2, CLCN6, CLCA4, CYP3A43, CYP3A4 and CYP2C9. Among the MTLE patients, panels of genes also appeared to be differentially methylated relative to disease duration, resistance to anti-epileptics and MRI alterations of hippocampal sclerosis. The peripheral epigenetic changes observed in MTLE could be involved in certain disease-related modulations and warrant further translational investigations.

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“…10 A recent review of 32 cross-sectional, cohort, case-control, and randomised controlled trials suggested that reduced bone density, impaired bone growth, and vitamin D deficiency may be seen in children treated with anticonvulsants. 25 In our study, individual vitamin D daily intake was calculated by dietitians. Sun exposure was limited in the institutional setting.…”

Section: Discussionmentioning

confidence: 99%