Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta-Analysis and Systematic Review

Wang, Jin‐Yuan; Liao, Biyun; Wang, Changsheng; Zhong, Ou; Lei, Xiaocan; Yang, Yuli

doi:10.1155/2022/7255413

Cited by 9 publications

(12 citation statements)

References 53 publications

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“…In addition, obese patients with antioxidant supplementation had higher levels of HDL and superoxide dismutase when compared to the placebo group. Antioxidant supplementation did not affect other parameters analyzed, including waist-to-hip ratio, leptin, fat mass, interleukin-6, C-reactive protein, alanine transaminase, and aspartate transaminase in obese patients [41].…”

Section: Nutritional Regulation Of Meta-inflammationmentioning

confidence: 80%

Major evidence of nutrological regulation in obese patients with meta-inflammation: a systematic review

Lessa¹,

Lessa²,

Oliveira³

et al. 2022

IJN

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Introduction: Obesity stands out as a multifactorial disease that can cause several public health problems. There are 2.0 billion overweight and obese people in the world, and Brazil ranks fifth in the world. A healthy nutritional status promotes immune function and can prevent the onset of a serious inflammatory process and severe infections, especially in times of a pandemic such as COVID-19. Objective: It was to highlight the main clinical considerations of nutrological and dietary regulation in obese patients with marked inflammatory processes and meta-inflammation through a systematic review. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from August to September 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 127 articles were found. A total of 74 articles were fully evaluated and 29 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 32 studies at high risk of bias and 25 studies that did not meet the GRADE. Research has shown that unbalanced dietary patterns, such as the Western diet, rich in simple sugars, refined carbohydrates, and saturated and trans fatty acids, lead to chronic inflammatory responses, increased fat deposits, and future comorbidities associated with overweight and obesity. Caloric restriction decreased polymerase chain reaction (PCR) in obese patients and diet administration over 12 weeks had a beneficial effect. Furthermore, obese patients with antioxidant supplementation had lower values of BMI, waist circumference, fasting blood glucose level, and insulin resistance homeostasis model assessment when compared to the placebo group, as well as lower total cholesterol levels, triglycerides, LDL, malondialdehyde and tumor necrosis factor-alpha. Supplementation of n-3 PUFA can significantly reduce serum PCR, tumor necrosis factor α (TNFα), and interleukin 6 (IL-6) concentrations.

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Section: Nutritional Regulation Of Meta-inflammationmentioning

confidence: 80%

Major evidence of nutrological regulation in obese patients with meta-inflammation: a systematic review

Lessa¹,

Lessa²,

Oliveira³

et al. 2022

IJN

View full text Add to dashboard Cite

show abstract

“…In the terminal differentiation of committed preadipocytes through the epigenomic activation of peroxisome proliferator-activator receptor-gamma (PPARA-γ) and the adipogenic stimuli [13,15] . The adipocyte gene expression in AT is maintained through the coordination of PPAR-γ and the CCAAT/enhancer binding protein (C/EBP) transcription factors [33] . Understanding this mechanism of adipogenesis and the players involved in it, can also provide therapeutic targets against metabolic diseases [11,33] .…”

Section: Introductionmentioning

confidence: 99%

“…The adipocyte gene expression in AT is maintained through the coordination of PPAR-γ and the CCAAT/enhancer binding protein (C/EBP) transcription factors [33] . Understanding this mechanism of adipogenesis and the players involved in it, can also provide therapeutic targets against metabolic diseases [11,33] .…”

Section: Introductionmentioning

confidence: 99%

“…For example, lipids or glycogen can compromise hepatic metabolic function and affect insulin action, exacerbating insulin resistance and possibly other metabolic pathologies associated to obesity. In obesity, it has been found an impairment in autophagy and insulin signaling [33,38] .…”

Section: Introductionmentioning

confidence: 99%

“…Another potential link is that autophagy acts in concert with the immune cells present in AT, and with endocrine renin-angiotensin system (RAS system) for regulation of blood pressure and fluid balance [33,39] , dysregulation of which can exhibit abnormalities in obesity. Furthermore, autophagy and obesity connections are related to the ER stress [40,41] .…”

Section: Introductionmentioning

confidence: 99%

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Harnessing the crosstalk of adipocytes, autophagy, and immune cells for immunotherapy in obesity

2022

Trends Immunother

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As a self-degradative and recycling program, autophagy plays an essential role in homeostasis and life. The connection between autophagy and the status of the adipose tissue (white or beige/brown) links to metabolic diseases such as obesity, type two diabetes mellitus (T2DM). Moreover, autophagy and the renin-angiotensin physiological system play a pivotal role in metabolic syndrome, a disease that can disrupt homeostasis in different organs, including adipose tissue. The crosstalk in adipose tissue maintains low inflammation, brown adipocytes, and autophagic machinery under control. The JAK-STAT signalization pathway and the paracrine action of hormones, adipokines, and cytokines play a role in maintaining the status of low inflammation, brown adipocytes, and autophagic machinery to harness the utmost for obesity immunotherapy.

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Childhood obesity, metabolic syndrome, and oxidative stress: microRNAs go on stage

González-Domínguez,

Belmonte,

González-Domínguez

2023

Rev Endocr Metab Disord

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The incidence of childhood obesity and metabolic syndrome has grown notably in the last years, becoming major public health burdens in developed countries. Nowadays, oxidative stress is well-recognized to be closely associated with the onset and progression of several obesity-related complications within the framework of a complex crosstalk involving other intertwined pathogenic events, such as inflammation, insulin disturbances, and dyslipidemia. Thus, understanding the molecular basis behind these oxidative dysregulations could provide new approaches for the diagnosis, prevention, and treatment of childhood obesity and associated disorders. In this respect, the transcriptomic characterization of miRNAs bares great potential because of their involvement in post-transcriptional modulation of genetic expression. Herein, we provide a comprehensive literature revision gathering state-of-the-art research into the association between childhood obesity, metabolic syndrome, and miRNAs. We put special emphasis on the potential role of miRNAs in modulating obesity-related pathogenic events, with particular focus on oxidative stress.

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Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta-Analysis and Systematic Review

Cited by 9 publications

References 53 publications

Major evidence of nutrological regulation in obese patients with meta-inflammation: a systematic review

Major evidence of nutrological regulation in obese patients with meta-inflammation: a systematic review

Harnessing the crosstalk of adipocytes, autophagy, and immune cells for immunotherapy in obesity

Childhood obesity, metabolic syndrome, and oxidative stress: microRNAs go on stage

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