Effects of Antioxidants on IL-6 Secretion Induced by IL-1 in Human Cultured Lung Fibroblasts. Involvement of NFκB

Raes, Martine; Renard, Patsy; Bosmans, Eugène; Delaive, Edouard; Remacle, José

doi:10.1007/978-3-0348-7424-3_9

Cited by 4 publications

(1 citation statement)

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“…N-acetylcysteine is frequently used in ventilator-treated infants and applied directly into the airways, usually by nebulization. It is primarily used for its mucolytic effect (26), but it may also act as a free oxygen radical scavenger (27), prevent the production of cytokines by stimulated fibroblasts (28), and prolong the human fibroblast life span (29).…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan Productionin vitroby Fetal Lung Fibroblasts and Epithelial Cells Exposed to Surfactants of N-acetylcysteine

Johnsson

Heldin

Sedin

et al. 1997

Upsala Journal of Medical Sciences

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Fetal human lung fibroblasts and feline lung epithelial cells were exposed to either a surfactant or N-acetylcysteine in various concentrations for 24-48 hours, after which the hyaluronan concentration in the culture medium was determined. Most of the experiments showed no stimulatory effect of either artificial or natural surfactant on hyaluronan synthesis. N-acetylcysteine 5-1 00 mg/mL induced progressive stimulation of hyaluronan synthesis by human fetal lung fibroblasts, resulting in a maximum hyaluronan concentration six times that released by unexposed cells. A slight increase in hyaluronan synthesis was also observed after exposure of feline fetal lung epithelial cells to N-acetylcysteine 50-1 00 pg/mL.

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