Effects of Antiviral Compounds on Symptoms and Infectivity of Cowpea Chlorotic Mottle Virus

Abstract

Effects of antiviral compounds on symptoms and as follows: treatment A-2 days and 1 infectivity of cowpea chlorotic mottle virus. Plant Disease 68:219-222. day before inoculation and immediately after inoculation; treatment B-2 days Symptoms of cowpea plants infected with cowpea chlorotic mottle virus (CCMV) were suppressed and 1 day before inoculation, immediately when plants were sprayed with ribavirin, amantadine, formycin, and methisazone but not after inoculation, and 1 day after when sprayed with MBC. 2-Thiouracil sprays increased or decreased symptoms, depending on inoculation; treatment C-immediately time of application. 2-Thiouracil, formycin, and methisazone also caused phytotoxicity on sprayed after inoculation; treatment D-immeplants. Ribavirin reduced and 2-thiouracil increased the infectivity of CCMV in some treatments, whereas the other compounds had little or no effect. Some ribavirin and formycin treatments of diately after inoculation and 1 day after soybean plants reduced CCMV local lesion numbers significantly. All other applications of the inoculation; treatment E-immediately antiviral compounds caused some but statistically nonsignificant reductions in local lesion after inoculation and 1, 2, 3, and 4 days formation. Ribavirin and amantadine did not significantly alter detectable viral antigen after inoculation; and treatment F-1, 3, concentrations in sap from treated, infected cowpea plants as determined by ELISA. 6, and 8 days after inoculation. In each experiment, one flat (20 X 12.5

Ribavirin targets sugar transporter 6 to suppress acquisition and transmission of rice stripe tenuivirus by its vector Laodelphax striatellus

“…Previous studies have provided evidence that ribavirin and 8-azaguanine have antiviral potential against a wide range of plant viruses. 18,20,22,27,28 In the present study, ribavirin and 8azaguanine were first screened for inhibition of acquisition and transmission of RSV. The toxicity of both compounds was assessed based on survival rate of SBPH.…”

“…16 Among the few antiviral compounds against animal and plant viruses, ribavirin (1-⊎-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) has been shown to be effective against infection by numerous animal and plant viruses such as hepatitis C virus (HCV), respiratory syncytial virus, Lassa virus, potato virus X, grapevine rupestris stem pitting-associated virus, cowpea chlorotic mottle virus, and tomato spotted wilt virus. [18][19][20][21][22] Similarly, 8-azaguanine can delay the development of tobacco mosaic disease. 23 Whether ribavirin and 8-azaguanine can inhibit the interaction between viral and insect vector components and then suppress or prevent virus transmission is not yet clear.…”

Evaluation of Tip Culture, Thermotherapy and Chemotherapy for Elimination of Peanut Mottle Virus from Arachis hypogaea

“…Chemotherapy has also been reported to be effective in elimination of virus from infected tissue. A synthetic riboside, ribavirin (1-B-D-ribofuranosyl-1,2,4triazole-3-carboxamide; virazole), has activity against several plant viruses (CAS-SELS and LONG 1982, HANSEN and LANE 1985, MANCINO and AGRIOS 1984. Virusfree Prunus serrulata Cult, were obtained after spraying plants weekly with 500 ppm ribavirin (HANSEN 1984).…”