Effects of apelin-13 in mice model of experimental pain and peripheral nociceptive signaling in rat sensory neurons

Canpolat, Sinan; Ozcan, Mete; Saral, Sinan; Kalkan, Ömer Faruk; Ayar, Ahmet

doi:10.3109/10799893.2015.1080274

Cited by 14 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As for apelin, peripheral injection of a single dose causes thermal hyperalgesia [478], but its intrathecal administration alleviates CFA-induced thermal and mechanical hypersensitivity in mice [479]. In models of formalin-induced pathological pain, intravenous injection of apelin reduces pain response during the second phase of the mouse formalin test, whereas intramuscular injection of apelin reduces licking/biting time during the second phase only at higher dose.…”

Section: Adipokinesmentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

View full text Add to dashboard Cite

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).

show abstract

Section: Adipokinesmentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…administration of 3 nmol/mouse apelin-13 induced hyperalgesia, and this process was related to APJ and the gamma-aminobutyric acid receptor type A (GABAA) receptor (Lv et al, 2013). Peripheral injection with apelin-13 (100 and 300 mg/kg) increased pain sensitivity in a mouse model of thermal stimuli-induced acute pain (Canpolat et al, 2016). Additionally, apelin, tumor necrosis factor-alpha (TNF-a), and interleukin (IL)-6 may be involved in the therapeutic effect of electroacupuncture (EA) on knee osteoarthritis, a common cause of joint pain (Ju et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The Apelin/APJ System in Psychosis and Neuropathy

Chen

Wang

2020

Front. Pharmacol.

View full text Add to dashboard Cite

Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the Gprotein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neuroprotection, stroke, and brain injury and protection, and highlights its promising potential as a therapeutic target for treatment of psychosis and neuropathy.

show abstract

“…Similarly, Hajimashhadi et al (2017) demonstrated that intrathecal injection of apelin-13 increased the autonomic activity and relieved signs of pain in rats with spinal cord injury. However, one study showed that peripheral administration of apelin-13 reduced the latency of painful stimuli and enhanced pain sensitivity in a dose- and time-dependent manner ( Canpolat et al, 2016 ), and intrathecal administration of ML221, an APJ antagonist, transiently reduced chronic constriction injury-induced pain hypersensitivity ( Xiong et al, 2017 ). These findings suggest that the spinal apelin/APJ system may drive neuropathic pain.…”

Section: Apelin-13mentioning

confidence: 99%

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies

Chen

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

The incidence of cerebral ischemia has increased in the past decades, and the high fatality and disability rates seriously affect human health. Apelin is a bioactive peptide and the ligand of the G protein-coupled receptor APJ. Both are ubiquitously expressed in the peripheral and central nervous systems, and regulate various physiological and pathological process in the cardiovascular, nervous and endocrine systems. Apelin-13 is one of the subtypes of apelin, and the apelin-13/APJ signaling pathway protects against cerebral ischemia by promoting angiogenesis, inhibiting excitotoxicity and stabilizing atherosclerotic plaques. In this review, we have discussed the role of apelin-13 in the regulation of cerebral ischemia and the underlying mechanisms, along with the therapeutic potential of the apelin-13/APJ signaling pathway in cerebral ischemia.

show abstract

Effects of apelin-13 in mice model of experimental pain and peripheral nociceptive signaling in rat sensory neurons

Abstract: Together these results indicate that apelin-13 can cause increased pain sensitivity after peripheral administration, but this effect does not involve calcium mediated signaling in primary sensory neurons.

Cited by 14 publications

References 28 publications

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

The Apelin/APJ System in Psychosis and Neuropathy

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies

Contact Info

Product

Resources

About