Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril

Nwachukwu, Daniel Chukwu; Aneke, E; Obika, L. F. O.; Nwachukwu, N

doi:10.4103/0253-7613.165194

Cited by 37 publications

(32 citation statements)

References 21 publications

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“…This study included only studies that investigated sour tea effect by comparing with inactive control intervention. However, the question remains, “Is the blood pressure lowering effect of sour tea comparable to conventional anti‐hypertensive pharmacological agents?” A casual analysis was run on six studies (A Herrera‐Arellano et al, ; Armando Herrera‐Arellano et al, ; Nwachukwu, Aneke, Nwachukwu, et al, ; Nwachukwu, Aneke, Obika, & Nwachukwu, ; Seck et al, ; Soleimani, Akbari, Soleimani, Mousavi, & Tamadon, ), which were not included in this review (because of nonsuitability of their control groups) to answer this question. The forest plot showed that, in general, the effect of sour tea on blood pressure is remarkably lower than antihypertensive drugs (Figure S1).…”

Section: Discussionmentioning

confidence: 99%

The efficacy of sour tea (Hibiscus sabdariffa L.) on selected cardiovascular disease risk factors: A systematic review and meta‐analysis of randomized clinical trials

Boushehri

Karimbeiki

Ghasempour

et al. 2020

Phytotherapy Research

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This study sought to summarize clinical evidence of sour tea (Hibiscus sabdariffa L.) administration on cardiovascular disease risk factors. PubMed, Scopus, Institute for Scientific Information Web of Science, and Google Scholar were systematically searched from inception to June 2019 to identify randomized clinical trials, which assessed the effect of sour tea consumption on lipid profiles, fasting plasma glucose, and blood pressure in adult populations. Mean and standard deviation for each parameter were extracted to calculate effect size. Cochrane Collaboration tools were used to evaluate risk of bias assessment. A total of seven randomized clinical trials consisting 362 participants were included in the meta-analysis. Pooled effect size demonstrated that sour tea consumption significantly reduces fasting plasma glucose (−3.67 mg/dl, 95% confidence interval, CI [−7.07, −0.27]; I 2 = 37%), systolic blood pressure (−4.71 mmHg, 95% CI [−7.87, −1.55]; I 2 = 53%), and diastolic blood pressure (−4.08 mmHg, 95% CI [−6.48, −1.67]; I 2 = 14%). Although no significant effect was observed on triacylglycerol, total cholesterol, and high-density lipoprotein cholesterolfollowing sour tea consumption, a trend toward a significant reduction was found in low-density lipoprotein cholesterol serum concentrations (p = 0.08). This systematic

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Section: Discussionmentioning

confidence: 99%

The efficacy of sour tea (Hibiscus sabdariffa L.) on selected cardiovascular disease risk factors: A systematic review and meta‐analysis of randomized clinical trials

Boushehri

Karimbeiki

Ghasempour

et al. 2020

Phytotherapy Research

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“…Hypertension has been positively correlated with thirst (Shailendra et al, 2011); it was reported to increase thirst perception (Stachenfeld, 2008), stimulate RAAS (Atlas, 2007) and alter sodium perception (Conlin et al, 1999). But H. sabdariffa consumption was reported to reduce plasma aldosterone level (Nwachukwu et al, 2015b) and exert antihypertensive action in humans (Herrea-Arellano et al, 2004;McKay et al, 2010). Decrease in plasma aldosterone was reported to cause natriuresis in normal humans (Gordon et al, 1997) and may be the mechanism responsible for the reduction in serum Na + with a consequent reduction in plasma osmolality and thus thirst perception.…”

Section: Discussionmentioning

confidence: 99%

Thirst perception in mild to moderate hypertensive Nigerians treated with aqueous extract of Hibiscus sabdariffa L.

Daniel¹,

Eddy²,

Nkiru³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Aqueous extract of Hibiscus sabdariffa L. is widely consumed in Nigeria as a local beverage used to quench thirst and also because of its antihypertensive action. The present study investigated the effect of consumption of aqueous extract of H. sabdariffa on thirst perception (TP) in mild to moderate hypertensive Nigerians. Fifty mild to moderate hypertensive patients attending medical out-patients clinic of Enugu State University Teaching Hospital were recruited for the study. They were randomly divided into two groups: A and B. Those in group A were given equivalent dose of placebo while group B received 150 mg/kg of H. sabdariffa daily for 4 weeks. All the subjects were given weekly appointments and a week worth of infusion. Thirst perception, serum electrolytes and blood pressure (BP) were measured at baseline and weekly during treatment. TP reduced significantly (p<0.001) in H. sabdariffa group compared to placebo throughout the duration of the experiment. Serum Na + reduced significantly (p<0.001) in H. sabdariffa compared to placebo group in weeks 3 and 4. Blood pressure (SBP, DBP and MAP) also reduced significantly (p<0.001) in weeks 3 and 4. Thus, consumption of H. sabdariffa reduced thirst perception in mild to moderate hypertensive Nigerians. This validates its traditional use to 'quench thirst' and complements its antihypertensive action. Reduction in serum Na + may be the possible mechanism of action.

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“…In a double-blind controlled randomized clinical study conducted with hypertensive to investigate effects of aqueous extract of HS on the RAAS, Placebo (150 mg/kg/day), lisinopril (10 mg once daily) and aqueous extract of HS (150 mg/kg/day) were given respectively for 4 weeks [43] . The results showed that HS reduced serum ACE and plasma aldosterone in patients with equal efficacy as lisinopril.…”

Section: Inhibition Of Ace Activitymentioning

confidence: 99%

Advances in the mechanisms of Hibiscus sabdariffa L. on hypertension

Liu

Liang

et al. 2020

E3S Web Conf.

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As a traditional edible beverage and medicinal application for high-pressure blood treatment with no side effects, Hibiscus sabdariffa L. (HS) has high prospect to be nutraceuticals as diet additive for anti-hypertension. The anti-hypertension effect of HS has also been scientific validated recently especially in diabetic patient and post-partum mothers. In this paper, we reviewed up-to-date mechanisms found for the anti-hypertensive effect of HS extracts. Those included the inhibition of angiotensin-converting enzymes (ACE) activity, diuretic effect, endothelium-derived nitric oxide-cGMP-relaxant pathway and inhibition of calcium (Ca2+)-influx into vascular smooth muscle cells, cholinergic and/or histaminergic mechanisms, reduction in the diffusion distance between capillaries and myocytes as well as new vessel formation. Phenolic acids, anthocyanins (e.g. cyanidin-3-sambubioside and delphinidin-3-sambubioside) and anthocyanin metabolites probably contribute mostly to the hypotensive activity., 0 Web of Conferences https://doi.org/10.

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Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril

Cited by 37 publications

References 21 publications

The efficacy of sour tea (Hibiscus sabdariffa L.) on selected cardiovascular disease risk factors: A systematic review and meta‐analysis of randomized clinical trials

The efficacy of sour tea (Hibiscus sabdariffa L.) on selected cardiovascular disease risk factors: A systematic review and meta‐analysis of randomized clinical trials

Thirst perception in mild to moderate hypertensive Nigerians treated with aqueous extract of Hibiscus sabdariffa L.

Advances in the mechanisms of Hibiscus sabdariffa L. on hypertension

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