Effects of Aqueous Extract of Nauclea latifolia Stem on Lipid Profile and Some Enzymes of Rat Liver and Kidney

Arise, Rotimi Olusanya; Akintola, A.A.; Olarinoye, J.B.; Balogun, Elizabeth Abidemi

doi:10.3923/ijp.2012.389.395

Cited by 25 publications

(37 citation statements)

References 12 publications

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“…Ethnobotanical information has it that plants numbering more than 800 are in use traditionally for treating diabetes owing to their potency, fewer side effects, and cheapness (9). Through their normoglycemic effect, ability to improve lipid metabolism, antioxidant defense system and capillary function, botanical products can enhance glucose metabolism and the overall condition of individuals with diabetes (10).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

Arise¹,

Aburo²,

Farohunbi³

et al. 2016

Acta Facultatis Medicae Naissensis

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SU M M A RYThis study was undertaken to determine the antidiabetic and antioxidant effects of oral administration of ethanolic extract of Moringa oleiferaflower on stretozotocin-induced diabetic rats at 100, 200, and 300 mg/kg b.w. Thirty (30) male experimental albino rats were grouped randomly into six groups: groups A, B, and F are the control, diabetic control and reference drug groups, while C-E received 100, 200, and 300mg/kg b.w of the extract, respectively. Blood samples and organs were collected to assay for blood glucose level and antioxidant enzymes.Levels of blood glucose, serum lipids and lipid peroxidation as well as aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) activities were significantly reduced (p<0.05) in STZ-induced diabetic rats orally administered ethanolic extract of M. oleifera flower. However, the body weight; catalase and superoxide dismutase activities were significantly increased (p < 0.05) when compared with the controls.M. oleifera flower ethanolic extract administered orally therefore exhibited improved lipid metabolism, glucose-lowering potential and is hence beneficial in preventing diabetic complications as a result of lipid peroxidation and oxidative systems in streptozotocin-induced diabetic rats. It could thus be employed therapeutically in managing diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

Arise¹,

Aburo²,

Farohunbi³

et al. 2016

Acta Facultatis Medicae Naissensis

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“…Binary combination of Artocarpus altilis, Enantia chlorantha, or Murraya koenigii with N. latifolia significantly increased the prophylactic and suppressive activities of the individual plants (Adebajo et al, 2014). In contrast, Arise et al (2012) reported hepatotoxic and nephrotoxic potentials of the aqueous extract of N. latifolia stem. The toxic potentials of N. latifolia on the kidney and liver of the animals presents a great concern in the consumption of this plant since this study also reports the pathological changes observed upon administration of the plant extract.…”

Section: Discussionmentioning

confidence: 70%

In vivo anti-plasmodial activity and histopathological analysis of water and ethanol extracts of a polyherbal antimalarial recipe

Ibukunoluwa¹

2017

J. Pharmacognosy Phytother.

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Anthocleista djalonensisThe powdered plant samples were screened for phytochemical constituents, proximate composition and mineral elements according to standard protocols. Plasmodium berghei infected mice were screened for parasitemia and administered with water and ethanol extracts of the combined plant sample. Toxicity and histopathological studies were carried out on the liver and kidney sections of the mice. Data were statistically analyzed. The powdered herbal recipe contained appreciable phytochemicals and important minerals. The concentrations administered for LD 50 did not elicit adverse reactions in the experimental animals, and no mortality was recorded. Histological studies revealed some pathology caused by the malaria parasite, as well as side effects of the extracts administered. This is discussed in relation to safety considerations.

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“…It is an ever-green fast growing plant commonly found in South-east Australia and Tasmania (Arise et al, 2009). It is the commonest eucalypts (Damjanović-Vratnicaet al, 2011), and also found in other countries including Nigeria.…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic and Antioxidant Potentials of Aqueous Extract of Eucalyptus Globulus in Experimentally-Induced Diabetic Rats

Saka¹,

Akhigbe²,

Ajayi³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Evaluation of the medicinal uses of plants remains a growing field of research. This study investigated the effects of Eucalyptus globules on alloxan -induced diabetic rats. Materials and Methods: Thirty male albino rats were randomized into 5 groups (n=6). Group A served as the control and was maintained on standard rat chow and water ad'libitum. Diabetes was induced in Group C, D and E animals by intraperitoneal administration of alloxan monohydrate (150 mg/kg). Groups B and D were orally administered with aqueous extract of Eucalyptus globulus at a dose of 150 mg/kg per oral daily for 4 weeks, while group E received glibenclamide at a dose of 0.6 mg/kg orally in addition. Fasting plasma glucose, antioxidant status (catalase and xanthine), malondialdehyde (MDA), liver function enzymes (AST and ALT) and bicarbonate ion (HC0 3 -) were assessed after 4 weeks. Results: Aqueous extract of Eucalyptus globulus leaves significantly reduced fasting plasma glucose level, MDA, HC0 3 -, and liver enzymes (P<0.05). The aqueous extract also increased serum levels of xantine oxidase and catalase significantly (P< 0.05). The effects of the aqueous extract on diabetic rats were similar to those of glibenclamide. Conclusion: Findings from this study revealed that aqueous extract of Eucalyptus globulus has hypoglycaemic property. The botanical also prevents complication of diabetes such as lipid peroxidation and ketoacidosis via its antioxidant potentials. This study lends credence to the ethnomedical use of the botanical in the management of diabetes.

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Effects of Aqueous Extract of Nauclea latifolia Stem on Lipid Profile and Some Enzymes of Rat Liver and Kidney

Cited by 25 publications

References 12 publications

Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

Antidiabetic and Antioxidant Activities of Ethanolic Extract of Dried Flowers of Moringa oleifera in Streptozotocin-induced Diabetic Rats

In vivo anti-plasmodial activity and histopathological analysis of water and ethanol extracts of a polyherbal antimalarial recipe

Anti-Diabetic and Antioxidant Potentials of Aqueous Extract of Eucalyptus Globulus in Experimentally-Induced Diabetic Rats

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