Effects of Artemisia monosperma ethanolic leaves extract on implantation, mid-term abortion and parturition of pregnant rats

Hijazi, Abdalla Mohammad; Salhab, Abdullazim Sammour

doi:10.1016/j.jep.2010.01.030

Cited by 35 publications

(31 citation statements)

References 16 publications

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“…The mechanism by which these antifertiliy properties were exerted is, however, different among the different species. In addition to oxytocin-like effects on rat uterus (Abu-Niaaj et al 1993), the ethanolic extracts of A. monosperma leaves exhibitied drastic effects on decreasing number of viable fetus implantation, increasing adsorbing sites with midterm abortion and delay of onset of delivery and failure of spontaneous parturition of pregnant rats (Hijazi & Salhab 2010). Artemisia herba-alba, on the other hand, causes a significant decrease in the relative ovarian weights and embryo weights in rats in addition to reductions in percentage pregnancies and in the number of implantation sites and viable fetus number Qazan et al 2007, Priya et al 2014.…”

Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

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The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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Context National statistical reports in Jordan indicate a decrease in the total fertility rate along with a parallel increase in contraceptive use. The folkloric use of medicinal herbs in gynecological disorders has been growing in Jordan, despite of deficient reports on the evidence-based safety and efficacy of these practices. Objective The aim of this comprehensive article is to review medicinal plants with claimed ethnonpharmacological usage in various gynecological and pregnancy-related issues in Jordan, and to assess their evidence-based pharmacological studies as well as their phytochemistry. Methods The published literature was surveyed using Google Scholar entering the terms ''ethnopharmacology AND Jordan AND infertility AND gynecology OR gestation''. We included ethnopharmacological surveys in Jordan with available full-text. Results Twelve articles were reviewed. Plant species which are commonly used for female gynecological issues such as Artemisia monosperma Del. and A. herba-alba Asso. (Asteraceae) have been found to exert an antifertility effect. Ricinus communis L. (Euphorbiaceae) and Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) had antifertility effects in male rats, but Nigella sativa oil L. (Ranunculaceae) and Cinnamon zeylanicum J. Presl (Lauraceae) were found to enhance it. Conclusion Using plants for gynecological disorders is a common practice in Jordan. Many of them, whether utilised for gynecological or non-gynecological conditions equally, were found to have detrimental effects on female or male fertility. Thus, couples planning pregnancy should be discouraged from the consumption of these herbs. Further local studies are warranted to confirm the appreciable beneficial pharmacological effects and safety of these plants. ARTICLE HISTORY

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Section: Herbal Remedies With Female Antifertility and Abortificiant mentioning

confidence: 99%

“…Contraindicated in pregnant women because of leaves' ethanol extracts' drastic effects on decreasing number of viable fetus implantation, increasing adsorbing sites with midterm abortion and delay of onset of delivery and failure of spontaneous parturition of pregnant rats (Hijazi & Salhab 2010).…”

Section: Introductionmentioning

confidence: 99%

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Akour

Kasabri

Afifi

et al. 2016

Pharmaceutical Biology

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“…[1][2][3] The plant is reputed in folk medicine for treatment of gastrointestinal disorders, 4 diabetes, 5 rheumatic pain, fever and to induce abortion. 6 In addition to the high antioxidant activity, 7 A. monosperma is reported for antimicrobial activities [8][9] as well as its insecticidal and antimalarial potentiation. [10][11][12][13] Grech-Baran and Pietrosiuk 14 reported the synthesis of two drugs, Artemisinin and Arglabin, first isolated from Artemisia species.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Flavones from Artemisia monosperma

Abu-Niaaj¹,

Katampe²

2018

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Background:Artemisia monosperma (Delile) is a green aromatic shrub that grows widely in the deserts of Middle East, Africa and China. This plant is commonly used in folk medicine as a remedy of a wide range of illness including gastrointestinal disorders, inflammation, diabetes and microbial infection. The different categories of the secondary metabolites identified from Artemisia species are recognized for their biological activities as antioxidants, anti-inflammatory and antimicrobial compounds. Objective: This study aims to isolate new flavonoids from A. monosperma that might have potential biological activities thus be translated into pharmaceutical uses. Materials and Methods: Air-dried A. monosperma extraction was done using different organic solvents. The methanolic extract was selected for isolation of flavonoids using column chromatography and thin layer chromatography. The chemical structures of the isolated flavones determined based on spectroscopic analysis of ultraviolet, mass and nuclear magnetic resonance spectra. Results: Nine flavone aglycones were isolated and identified from the methanolic extract; four of which are reported for the first time from A. monosperma. These include: 5-Hydroxy-3',4', 6,7-tetramethoxyflavone; 3',5-dihydroxy-4',6,7-trimethoxyflavone (eupatorin); 5,6-dihydroxy-4',7-dimethoxyflavone(ladanein); and 2',4',5-trihydroxy-5',6,7-trimethoxyflavone (arcapillin). The remaining five flavones were previously identified from this plant as : 4',5-Dihydroxy-3',6,7-tri-methoxyflavone(cirsilineol);5,7-dihydroxy-3',4',6-trimethoxyflavone (eupatilin);4',5,7-trihydroxy-3',6-dimethoxyflavone(jaceosidin);4',5-dihydroxy-6,7-dimethoxy-flavone (circimaritin) and 4',5,7-trihydroxy-6-methoxyflavone (hispidulin). In addition, two acetophenone derivatives were isolated from fractions yielded selected flavones and these were identified as 4-hydroxyacetophenone and 3-(2-hydroxymethyl-2-buten-4-yl)-4-hydroxyaceto-phenone. Conclusion: This successful isolation of these natural flavonoids from A. monosperma can contribute further to the evaluation of bioactive compounds against disorders including but not limited to inflammatory associated disorders and microbial infections. Lubna

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“…Altered hormonal signals, as exemplified by a prolonged estrous cycle and an extension of the estrus phase could lead to extreme subfertility (Akpantah et al, ). The increase in dead fetuses and early resorptions can account for the decrease in the number of live fetuses/litter and attributed to inhibition of implantation activity (Hijazi and Salhab, ). Maternal toxicity may have been the trigger for the embryo lethality (ElMazoudy et al, ) because the normal maternal physiology is important for the normal development of the fetus (Chahoud et al, ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy ofGinkgo bilobaon Vaginal Estrous and Ovarian Histological Alterations for Evaluating Anti‐Implantation and Abortifacient Potentials in Albino Female Mice

ElMazoudy

Attia

2012

Birth Defects Research Pt B

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Ginkgo extract, EGb 761 is known as a vasoregulatory variable for the conventional reproduction therapy. EGb 761 was orally administered in 0 (control), 3.7, 7.4, and 14.8 mg/kg bw/day for 28 days (thereafter mated with normal fertile male), from day 1 to day 7 of pregnancy or from the 10th to 18th day of pregnancy, respectively. Vaginal smears were performed daily. On 20th day of pregnancy, the females were killed by cervical dislocation and their kidneys, liver, brain, placenta, spleen and ovaries were removed and weighed. The ovaries were prepared for histological examinations, and then ovarian follicles were counted. Maternal toxicity, estrous cycle, reproductive hormones, ovarian follicle counts, resorption index, implantation index, fetal viability and fetuses, and placenta mean weights were evaluated. There was a dose-dependent ovarian toxic effect of EGb 761. Ovarian follicle counts, resorption index, implantation index, fetal viability were significantly reduced in 14.8 mg/kg bw/day dose. Treatment with 14.8 mg/kg bw/day EGb 761 induced disruption of estrous cycle and caused maternal toxicity, in addition to fetal toxicity. Therefore, the data obtained indicate that Ginkgo biloba extract at 14.8 mg/kg bw/day dose level exhibit toxic effect on reproductive cyclicity and could have anti-implantation and abotifacient properties in female mice.

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Effects of Artemisia monosperma ethanolic leaves extract on implantation, mid-term abortion and parturition of pregnant rats

Cited by 35 publications

References 16 publications

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology

Isolation and Characterization of Flavones from Artemisia monosperma

Efficacy ofGinkgo bilobaon Vaginal Estrous and Ovarian Histological Alterations for Evaluating Anti‐Implantation and Abortifacient Potentials in Albino Female Mice

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