Effects of Astaxanthin and Vitamin C on the Prevention of Gastric Ulcerations in Stressed Rats

Nishikawa, Yoshiyuki; Minenaka, Yoshiharu; Ichimura, Mika; Tatsumi, Kaori; Nadamoto, Tomonori; Urabe, Kimiko

doi:10.3177/jnsv.51.135

Cited by 30 publications

(20 citation statements)

References 19 publications

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“…Although ascorbic acid has gastroprotective effects on different experimental models like the stress-, aspirin-, different antirheumatic drugs-, and ethanol-induced gastric mucosal injuries, the role of the gastroprotective mechanism pathway in mediating the action of ascorbic acid is still unknown [27][28][29][30]. The present study examined the gastroprotective effects of three doses (100, 200, and 400 mg/kg body wt.)…”

Section: Discussionmentioning

confidence: 99%

“…Thus, ascorbic acid acts as co-antioxidant for α-tocopherol by converting α-tocopheroxyl radical to α-tocopherol and helps to prevent the α-tocopheroxyl radical-mediated peroxidation reactions [26]. Although ascorbic acid has a gastroprotective effects on different experimental models like the stress- [27], aspirin- [28], different antirheumatic drugs- [29], and ethanol- [30] induced gastric mucosal injuries, the role of the gastroprotective mechanism pathway in mediating the action of ascorbic acid is still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Gastroprotective and Anti-oxidative Properties of Ascorbic Acid on Indomethacin-induced Gastric Injuries in Rats

Koç

İmik

Odabaşoğlu

2008

Biol Trace Elem Res

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Reactive oxygen species (ROS) have been implicated in the etiology of indomethacin-induced gastric mucosal damage. This study investigated ascorbic acid (vitamin C)'s protective effects against oxidative gastric mucosal damage induced by indomethacin. Ascorbic acid is a powerful antioxidant because it can donate a hydrogen atom and form a relatively stable ascorbyl free radical. We have investigated alterations in the levels of myeloperoxidase, antioxidant system enzymes (glutathione S-transferase, superoxide dismutase, glutathione reductase, catalase, glutathione peroxidase), lipid peroxidation and glutathione, as markers for ulceration process following oral administration of ascorbic acid, famotidine, lansoprazole, and ranitidine in rats with indomethacin-induced ulcers. In the present study, we found that (1) ascorbic acid, famotidine, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages; (2) the administration of indomethacin caused a significant decrease in the levels of superoxide dismutase, glutathione peroxidase, glutathione S-transferase and glutathione, and an increase in the lipid peroxidation level; (3) the administration of ascorbic acid reversed the trend, inducing a significant increase of these enzymes' levels and a reduction in lipid peroxidation level in tissues; and (4) catalase, glutathione reductase and myeloperoxidase activities, increased by indomethacin, were found to be lower in the ascorbic acid, famotidine, lansoprazole and ranitidine-treated groups. The results indicate that the gastroprotective properties of ascorbic acid could be related to its positive effects on the antioxidant system and myeloperoxidase activity in indomethacin-induced gastric ulcers in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gastroprotective and Anti-oxidative Properties of Ascorbic Acid on Indomethacin-induced Gastric Injuries in Rats

Koç

İmik

Odabaşoğlu

2008

Biol Trace Elem Res

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“…The results indicated that rats given astaxanthins prior to stressing were appreciably protected against the evolution of gastric ulcerations. In particular, ulcer indexes were smaller with the rat group fed astaxanthin from H. pluvialis than the other two groups, indicating that astaxanthin from H. pluviali is more efficacious in preventing gastric ulcer evolution caused by stress [45].…”

Section: Anti-helicobacter Pylori Activitymentioning

confidence: 94%

“…Wang et al [44] demonstrated that mice treated with H. pluvialis algal meal showed significantly lower colonization levels and lower inflammation scores. Nishikawa et al [45] compared physiologically and biochemically the effects of three kinds of astaxanthins, including two extracts from the microalga H. pluvialis and the red yeast P. rhodozyma, and a synthetic astaxanthin, on stressed rats. The results indicated that rats given astaxanthins prior to stressing were appreciably protected against the evolution of gastric ulcerations.…”

Section: Anti-helicobacter Pylori Activitymentioning

confidence: 99%

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Yuan

Peng

Yin

et al. 2010

Molecular Nutrition Food Res

557

309

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The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl₂-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.

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“…These species have been implicated in chronic diseases, including cardiovascular disease, stroke, cancer, neurodegenerative diseases, and cataractogenesis (14,15). Ascorbic acid has been shown to have gastroprotective effects in different experimental models of gastric mucosal injury induced by stress, various antirheumatic drugs, or ethanol (16)(17)(18). It has also been suggested that ascorbic acid supplementation is protective against not only indomethacin-induced gastric ulcers in rats (19) but also aspirin-induced gastric mucosal damage in healthy volunteers with (8) or without H. pylori infection (20).…”

Section: Discussionmentioning

confidence: 99%

Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan

Miyake

Akimoto

Kusakabe

et al. 2013

J Nutr Sci Vitaminol

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SummaryWe investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p,0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.

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Effects of Astaxanthin and Vitamin C on the Prevention of Gastric Ulcerations in Stressed Rats

Cited by 30 publications

References 19 publications

Gastroprotective and Anti-oxidative Properties of Ascorbic Acid on Indomethacin-induced Gastric Injuries in Rats

Gastroprotective and Anti-oxidative Properties of Ascorbic Acid on Indomethacin-induced Gastric Injuries in Rats

Potential health‐promoting effects of astaxanthin: A high‐value carotenoid mostly from microalgae

Water-Soluble Vitamin Deficiencies in Complicated Peptic Ulcer Patients Soon after Ulcer Onset in Japan

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