Effects of Au/TiO2 metallic nanoparticles on Unio ravoisieri: assessment through an oxidative stress and toxicity biomarkers

Dellali, Mohamed; Khallouli, Altaf; Harrath, Abdel Halim; Falodah, Fawaz; Alwasel, Saleh; Beyrem, Hamouda; Gyedu-Ababio, Thomas; Rohal-Lupher, Melissa; Boufahja, Fehmi

doi:10.1007/s11356-020-12305-7

Cited by 10 publications

(11 citation statements)

References 87 publications

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“…Interestingly, while the addition of dissolved organic matter reduced bioavailability and oxidative stress, AChE activity was still affected, suggesting susceptibility of bivalves towards nAg at the neurological level. Disturbance in the cholinergic system in mussels, as determined by AChE activity inhibition, was observed with other nanoparticles, such as gold-coated nTiO 2 [27]. The decrease was accompanied with increased oxidative stress, as determined by catalase, glutathione Stransferase activities and LPO levels in tissues.…”

Section: Discussionmentioning

confidence: 95%

The Influence of Silver Nanoparticle Form on the Toxicity in Freshwater Mussels

et al. 2022

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The contribution of the form of silver nanomaterials (nAg) towards toxicity in aquatic organisms is not well understood. The purpose of this study was to examine the toxicity of various structures (sphere, cube and prism) of nAg in Dreissena bugensis mussels. Mussels were exposed to increasing concentrations of polyvinyl-coated nAg of the same size for 96 h at 15 °C. They were then analyzed for biophysical changes in the cytoplasm (viscosity, protein aggregation and lipids), neuro-activity (fractal kinetics of acetylcholinesterase (AChE)), oxidative stress (labile zinc (Zn) and lipid peroxidation) and inflammation (arachidonate cyclooxygenase). Although some decreasing effects in protein aggregation were observed, viscosity was more strongly decreased in mussels exposed to spheric and prismatic nAg. The activity of AChE was significantly decreased in the following form-dependent manner: prismatic > cubic > spheric nAg. The fractal dimension of AChE reactions was reduced by all geometries of nAg, while dissolved Ag had no effects. For nanoparticles with the same coating and relative size, spheric nAg produced more significant changes towards the fractal dimension of AChE, while prismatic nAg increased both protein aggregation and viscosity, whereas cubic nAg decreased protein aggregation in the cytoplasm. It is concluded that the geometries of nanoparticles could influence toxicity in aquatic organisms.

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Section: Discussionmentioning

confidence: 95%

The Influence of Silver Nanoparticle Form on the Toxicity in Freshwater Mussels

et al. 2022

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“…These organisms are abundant, of sufficient size to carry biochemical analyses, easy to sample and valuable from an economic and ecologic perspective. The fact that most bivalves are sessile or sedentary and are filter feeders make them ideal for laboratory bioassays [11,12]. The biomarkers cover several molecular, biochemical, and cellular changes, which reflect the health status of a studied population [7].…”

Section: Introductionmentioning

confidence: 99%

“…The current work focused on the response of the freshwater mussel Unio ravoisieri to TiO 2 NPs exposure. We are aware of a single study, which used a hybrid (Au/TiO 2 ) nanocomposite that has partially covered this topic (Dellali et al [11]). In this study, the Au/TiO 2 NPs comprised many-faceted quasi-spherical gold cores (10 nm) surrounded by closely packed titanium dioxide nanoparticles (25 nm) forming a pattern that facilitated good dispersion.…”

Section: Introductionmentioning

confidence: 99%

“…The current experiment aimed for a better understanding of the TiO 2 NPs toxicity by employing a wide range of concentrations (i.e., 10, 100, and 1000 µg•L −1 ) and to choose relevant concentrations of the metallic alloy MNPs of Au/TiO 2 (100 and 200 µg•L −1 ). The increasing contamination rate with nanoparticles (NPs) at concentrations ranging in concentration several orders of magnitude in surface and sewage treatment effluent waters [14,15] raises nowadays serious concerns on their potential toxic effects for aquatic ecosystems [11]. Moreover, the results could provide a useful tool for improving the current knowledge gap on the toxic effects of TiO 2 NPs on aquatic life.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the results could provide a useful tool for improving the current knowledge gap on the toxic effects of TiO 2 NPs on aquatic life. The novelty of the current work is the fact that most previous experiments have focused on marine taxa [11], despite the fact that lotic ecosystems are the primary receptacles of these xenobiotics. Therefore, we tried in the current study to fill this knowledge gap by answering to the following questions:…”

Section: Introductionmentioning

confidence: 99%

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Titanium Dioxide Nanoparticles Are Toxic for the Freshwater Mussel Unio ravoisieri: Evidence from a Multimarker Approach

et al. 2021

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The current work investigated the ecotoxicological effects induced by Titanium Dioxide (TiO2) nanoparticles (NPs), used at three different concentrations (C1 = 10 μg·L−1, C2 = 100 μg·L−1 and C3 = 1000 μg·L−1) in a laboratory experiment, on the freshwater mussel Unio ravoisieri. Biochemical analyses of gills and digestive glands revealed a stress-related disruption of the antioxidant system. The catalase activity and the rates of malonedialdehyde and hydrogen peroxide production were significantly higher in both organs following the exposure to TiO2 NPs and was concentration-dependent. In addition, based on the observed changes in acetylcholinesterase activity, it can be concluded that the disturbance threshold for the cholinergic system was less than 1 mg·L−1 of TiO2. Overall, the results suggest that the mussel Unio ravoisieri could be used as a sentinel species in monitoring surveys assessing the environmental impact of metallic nanoparticles in freshwater systems.

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