Effects of aurothiomalate and gold(III) complexes on spontaneous motility of isolated human oviduct

Abstract

Organic gold complexes have different biological activity, depending on their potential for interactions with key functional molecules.The aim of this study was to investigate potential of several newly synthesized organic gold complexes to influence spontaneous motility of the Fallopian tubes.The effects of [Au(bipy)Cl(2)](+) (dichloride(2,2'-bipyridyl)aurate(III)-ion), aurothiomalate, [Au(DMSO)(2)Cl(2)]Cl and DMSO on spontaneous motility of Fallopian tubes were tested on the isolated tube segments in vitro. Aurothiomalate (from 2.9 × 10(-9) to 4.9 × 10(-4) M/l), [Au(bipy)Cl(2)]Cl (from 3.3 × 10(-9) to 4.2 × 10(-5) M/l) and DMSO (from 1.9 × 10(-8) to 1.0 × 10(-5) M/l) did not affect spontaneous contractions of the isolated Fallopian tube ampulla, while [Au(DMSO)(2)Cl(2)]Cl (from 2.9 × 10(-9) to 4.2 × 10(-5) M/l) showed concentration-dependent increase (stimulation) of spontaneous contractions of the isolated Fallopian tube isthmus, and remained without effect on the isolated ampulla.The drugs designed as organic gold complexes with weaker bonds between the gold itself and organic part of a molecule could adversely affect motility of the Fallopian tubes, and theoretically fertility of women taking such drugs in their reproductive age.

Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(iii) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines

“…[7][8][9][10] Gold(III) compounds, which are isoelectronic and isostructural to platinum(II) compounds, hold promise as possible anticancer agents. [11][12][13] Surprisingly, only a few reports exist in the literature describing the cytotoxic properties and the in vivo anticancer effects of gold(III) compounds. [14][15][16] Some preliminary data, suggesting a direct interaction with DNA as the basis for their cytotoxic effects, were previously reported.…”

Characterization and Antitumor Activity of Chitosan/Poly (Vinyl Alcohol) Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

“…Gold complexes have recently gained significant attention as a class of compounds with different pharmacodynamic and kinetic properties than cisplatin with strong cell growth inhibiting effects [53,54]. The cell growth inhibiting effects, in many cases, could be related to anti-mitochondrial effects that make the gold complexes interesting [53,55,56]. However, the NPs can be incorporated with dual targets, the androgen receptor (AR1) which is a target for prostatic cancer therapy and a G protein receptor (GRC6A), which is seen upregulated in cancer prostate.…”

Histological Changes in Renal, Hepatic and Cardiac Tissues of Wistar Rats after 6 Weeks Treatment with Bipyridine Gold (III) Complex with Dithiocarbamate Ligands

“…With their intrinsic, highly potent tumor anti proliferative potential, gold (III) complexes have recently attained an important role. Their mechanism of action is different from cisplatin [6], but they are electronically and structurally homogenous to platinum (II) compounds [7]. The actual breakthrough for the use of gold compounds will come when these compounds are designed to be more clinically effective and potent, with enhanced cancer cell specificity and selectivity along with diminished organ toxicity [1].…”