Effects of B-Vitamin Deficiencies and of Starvation on Liver Enzyme Activities of Growing Rats

Stielau, W. J.; Freedland, R. A.; Meyer, James H.

doi:10.1093/jn/87.1.109

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Such a situation may thus be responsible for the difficulties attending the resolution of pyridoxal phosphate in the present investigation. The well-documented evidence (Brin, Olson & Stare, 1954;Caldwell & McHenry, 1953;Stielau, Freedland & Meyer, 1965) that vitamin B6 deficiency leads to a decrease in the activities of many well-known enzyme systems requiring pyridoxal phosphate as an obligatory cofactor prompted an investigation into the effects of vitamin B6 deficiency in rats on the activity of the hepatic system degrading L-serine 0-sulphate. Vitamindeficient animals were produced either by feeding them on vitamin-deficient diets, or alternatively by oral administration of isonicotinic acid hydrazide (isoniazid) (Meister & Downey, 1956).…”

Section: Experimental and Resultsmentioning

confidence: 99%

“…The relationship between pyridoxal phosphate and the aminotransferases is now well established and numerous publications have appeared in which tissue aminotransferase activity is depressed in vitamin B6-deficient animals (Stielau et al 1965). The activities of hepatic alanine aminotransferase fall dramatically in vitamin B6-deficient animals to a value that remains unaltered by the addition of pyridoxal phosphate (final concn.…”

Section: Experimental and Resultsmentioning

confidence: 99%

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A rat liver system that catalyses a pyridoxal phosphate-independent αβ-elimination

Tudball

Thomas

Fowler

1969

Biochemical Journal

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1. Attempts were made to demonstrate the presence of pyridoxal phosphate in the rat liver system catalysing the alphabeta-elimination of l-serine O-sulphate. 2. Methods designed to resolve protein-bound cofactor, spectroscopic examination of a purified enzyme system and attempted reactivation of apo-(alanine aminotransferase) failed to demonstrate the presence of pyridoxal phosphate. 3. The activity of the alphabeta-eliminating system remained constant in vitamin B(6)-deficient animals even though the activities of other pyridoxal phosphate-dependent systems fell markedly. 4. The metabolism of l-serine O[(35)S]-sulphate in vivo appears to be normal in vitamin B(6)-deficient animals. 5. No incorporation of tritium into the alphabeta-eliminating system occurred after administration of tritiated pyridoxine to experimental animals.

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